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    TCF15 transcription factor 15 [ Homo sapiens (human) ]

    Gene ID: 6939, updated on 9-Dec-2024

    Summary

    Official Symbol
    TCF15provided by HGNC
    Official Full Name
    transcription factor 15provided by HGNC
    Primary source
    HGNC:HGNC:11627
    See related
    Ensembl:ENSG00000125878 MIM:601010; AllianceGenome:HGNC:11627
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EC2; PARAXIS; bHLHa40
    Summary
    The protein encoded by this gene is found in the nucleus and may be involved in the early transcriptional regulation of patterning of the mesoderm. The encoded basic helix-loop-helix protein requires dimerization with another basic helix-loop-helix protein for efficient DNA binding. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in fat (RPKM 5.9), heart (RPKM 2.3) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See TCF15 in Genome Data Viewer
    Location:
    20p13
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (604257..610309, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (647994..654046, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (584901..590953, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene TBC1 domain family member 20 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:442560-442708 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12577 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12578 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:456844-457048 Neighboring gene casein kinase 2 alpha 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17440 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:522754-523447 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12579 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:524141-524834 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17444 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:552949-553709 Neighboring gene Sharpr-MPRA regulatory region 14258 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:572175-572398 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12580 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12581 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:591860-592360 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:592361-592861 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:596343-597542 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:601772-602601 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:602602-603430 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:614811-615388 Neighboring gene uncharacterized LOC107985423 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12582 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:642152-642765 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:642766-643378 Neighboring gene sulfiredoxin 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:653674-654187 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12583 Neighboring gene scratch family transcriptional repressor 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in developmental process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ear development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of epithelial cell apical/basal polarity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mesenchymal to epithelial transition IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mesoderm development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in muscle organ morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of hematopoietic stem cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuromuscular process controlling posture IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in paraxial mesoderm development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of stem cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in post-anal tail morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in respiratory system process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in skeletal system morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in somitogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in stem cell population maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    transcription factor 15
    Names
    TCF-15
    basic helix-loop-helix transcription factor 15
    class A basic helix-loop-helix protein 40
    protein bHLH-EC2
    transcription factor 15 (basic helix-loop-helix)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004609.4NP_004600.3  transcription factor 15

      Status: REVIEWED

      Source sequence(s)
      AL133231
      Consensus CDS
      CCDS33432.1
      UniProtKB/Swiss-Prot
      Q12870, Q9NQQ1
      UniProtKB/TrEMBL
      A4LBB6
      Related
      ENSP00000246080.3, ENST00000246080.4
      Conserved Domains (1) summary
      cd11470
      Location:66131
      bHLH_TS_TCF15_paraxis; basic helix-loop-helix (bHLH) domain found in transcription factor 15 (TCF-15) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      604257..610309 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      647994..654046 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)