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    CREB5 cAMP responsive element binding protein 5 [ Homo sapiens (human) ]

    Gene ID: 9586, updated on 3-Dec-2024

    Summary

    Official Symbol
    CREB5provided by HGNC
    Official Full Name
    cAMP responsive element binding protein 5provided by HGNC
    Primary source
    HGNC:HGNC:16844
    See related
    Ensembl:ENSG00000146592 MIM:618262; AllianceGenome:HGNC:16844
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CREB-5; CREBPA; CRE-BPA
    Summary
    The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc-finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in gall bladder (RPKM 3.3), brain (RPKM 3.0) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CREB5 in Genome Data Viewer
    Location:
    7p15.1-p14.3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (28299321..28825894)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (28436682..28963385)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (28338940..28865511)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene JAZF zinc finger 1 Neighboring gene MPRA-validated peak6455 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25794 Neighboring gene JAZF1 antisense RNA 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr7:28330425-28331392 and GRCh37_chr7:28331393-28332360 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:28332361-28333326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:28350942-28351442 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:28398093-28398687 Neighboring gene peptidylprolyl isomerase A pseudogene 80 Neighboring gene Sharpr-MPRA regulatory region 5389 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25795 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25796 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25797 Neighboring gene Sharpr-MPRA regulatory region 14916 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18046 Neighboring gene VISTA enhancer hs1604 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:28651065-28652264 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:28682874-28683374 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:28683375-28683875 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25798 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:28725036-28725544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25799 Neighboring gene ribosomal protein S2 pseudogene 30 Neighboring gene NANOG hESC enhancer GRCh37_chr7:28808272-28808863 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:28832834-28833543 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25800 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:28877832-28878523 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18047 Neighboring gene Sharpr-MPRA regulatory region 6215 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:29025827-29026326 Neighboring gene CPVL antisense RNA 2 Neighboring gene TLR4 interactor with leucine rich repeats Neighboring gene carboxypeptidase vitellogenic like

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genetic Variants Associated with Serum Thyroid Stimulating Hormone (TSH) Levels in European Americans and African Americans from the eMERGE Network.
    EBI GWAS Catalog
    Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.
    EBI GWAS Catalog
    Genome-wide association study of co-occurring anxiety in major depression.
    EBI GWAS Catalog
    Genome-wide meta-analysis for severe diabetic retinopathy.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog
    Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    enables cAMP response element binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in nucleus IC
    Inferred by Curator
    more info
    PubMed 

    General protein information

    Preferred Names
    cyclic AMP-responsive element-binding protein 5
    Names
    cAMP response element-binding protein CRE-BPa
    cAMP-response element-binding protein A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011666.3NP_001011666.1  cyclic AMP-responsive element-binding protein 5 isoform delta

      See identical proteins and their annotated locations for NP_001011666.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks several 5' exons and uses an alternate 5' terminal exon which results in the use of a downstream start codon, compared to variant 1. It encodes isoform delta which is shorter and contains a distinct N-terminus compared to isoform alpha.
      Source sequence(s)
      AC005013, BC059400, BQ130001
      Consensus CDS
      CCDS43563.1
      UniProtKB/TrEMBL
      Q59G47
      Related
      ENSP00000379592.2, ENST00000396298.6
      Conserved Domains (1) summary
      cd14687
      Location:238297
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    2. NM_004904.4NP_004895.2  cyclic AMP-responsive element-binding protein 5 isoform beta

      See identical proteins and their annotated locations for NP_004895.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a 5' exon and uses an alternate 5' terminal exon which results in the use of a downstream in-frame start codon, compared to variant 1. It encodes isoform beta which has a shorter N-terminus compared to isoform alpha.
      Source sequence(s)
      AB451409, AC005013, AC006980, BQ130001, L05911
      Consensus CDS
      CCDS5418.1
      UniProtKB/Swiss-Prot
      Q02930
      Related
      ENSP00000379594.2, ENST00000396300.6
      Conserved Domains (1) summary
      cd14687
      Location:370429
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    3. NM_182898.4NP_878901.2  cyclic AMP-responsive element-binding protein 5 isoform alpha

      See identical proteins and their annotated locations for NP_878901.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript, and encodes the longest isoform (alpha).
      Source sequence(s)
      AB451409, AC005013, AC006367, BQ130001, L05515
      Consensus CDS
      CCDS5417.1
      UniProtKB/Swiss-Prot
      A8KA51, B4DU13, B5BUH3, C9JK47, Q02930, Q05886, Q06246, Q75N02, Q86UJ9
      Related
      ENSP00000350359.2, ENST00000357727.7
      Conserved Domains (1) summary
      cd14687
      Location:377436
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    4. NM_182899.5NP_878902.2  cyclic AMP-responsive element-binding protein 5 isoform gamma

      See identical proteins and their annotated locations for NP_878902.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two 5' exons and uses an alternate 5' terminal exon which results in the use of a downstream in-frame start codon, compared to variant 1. It encodes isoform gamma which has a shorter N-terminus compared to isoform alpha.
      Source sequence(s)
      AB451409, AC005013, AC006367, BQ130001, L05913
      Consensus CDS
      CCDS43562.1
      UniProtKB/Swiss-Prot
      Q02930
      Related
      ENSP00000379593.2, ENST00000396299.6
      Conserved Domains (1) summary
      cd14687
      Location:344403
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      28299321..28825894
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017012807.2XP_016868296.1  cyclic AMP-responsive element-binding protein 5 isoform X2

    2. XM_017012808.2XP_016868297.1  cyclic AMP-responsive element-binding protein 5 isoform X3

      UniProtKB/Swiss-Prot
      A8KA51, B4DU13, B5BUH3, C9JK47, Q02930, Q05886, Q06246, Q75N02, Q86UJ9
      Conserved Domains (1) summary
      cd14687
      Location:377436
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    3. XM_017012806.2XP_016868295.1  cyclic AMP-responsive element-binding protein 5 isoform X1

      UniProtKB/Swiss-Prot
      Q02930
      Conserved Domains (1) summary
      cd14687
      Location:370429
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    4. XM_005249906.2XP_005249963.1  cyclic AMP-responsive element-binding protein 5 isoform X1

      See identical proteins and their annotated locations for XP_005249963.1

      UniProtKB/Swiss-Prot
      Q02930
      Conserved Domains (1) summary
      cd14687
      Location:370429
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    5. XM_024447005.2XP_024302773.1  cyclic AMP-responsive element-binding protein 5 isoform X5

      Related
      ENSP00000387197.1, ENST00000409603.5
      Conserved Domains (1) summary
      cd14687
      Location:344403
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    6. XM_047421068.1XP_047277024.1  cyclic AMP-responsive element-binding protein 5 isoform X4

    7. XM_047421069.1XP_047277025.1  cyclic AMP-responsive element-binding protein 5 isoform X4

    8. XM_047421067.1XP_047277023.1  cyclic AMP-responsive element-binding protein 5 isoform X1

    9. XM_047421070.1XP_047277026.1  cyclic AMP-responsive element-binding protein 5 isoform X6

      UniProtKB/TrEMBL
      Q59G47

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      28436682..28963385
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359399.1XP_054215374.1  cyclic AMP-responsive element-binding protein 5 isoform X8

    2. XM_054359397.1XP_054215372.1  cyclic AMP-responsive element-binding protein 5 isoform X1

    3. XM_054359395.1XP_054215370.1  cyclic AMP-responsive element-binding protein 5 isoform X7

    4. XM_054359400.1XP_054215375.1  cyclic AMP-responsive element-binding protein 5 isoform X5

    5. XM_054359401.1XP_054215376.1  cyclic AMP-responsive element-binding protein 5 isoform X4

    6. XM_054359396.1XP_054215371.1  cyclic AMP-responsive element-binding protein 5 isoform X2

    7. XM_054359398.1XP_054215373.1  cyclic AMP-responsive element-binding protein 5 isoform X1

    8. XM_054359402.1XP_054215377.1  cyclic AMP-responsive element-binding protein 5 isoform X6

      UniProtKB/TrEMBL
      Q59G47