Hpgds hematopoietic prostaglandin D synthase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hpgdsprovided by RGD
Official Full Name: hematopoietic prostaglandin D synthaseprovided by RGD
Primary source: RGD:69251
See related: EnsemblRapid:ENSRNOG00000006583 AllianceGenome:RGD:69251
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ptgds2
Summary: Predicted to enable several functions, including glutathione transferase activity; metal ion binding activity; and prostaglandin-D synthase activity. Predicted to be involved in glutathione metabolic process and prostaglandin metabolic process. Predicted to act upstream of or within negative regulation of male germ cell proliferation. Predicted to be located in cytosol and nucleoplasm. Orthologous to human HPGDS (hematopoietic prostaglandin D synthase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 1130.0), Thymus (RPKM 141.8) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 4q31

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (95698265..95727733, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (94368426..94397931, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (95945356..95970666, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

L-PGDS is involved in the balance of VSMC proliferation and apoptosis
Title: Prostaglandin D2 synthase inhibits the exaggerated growth phenotype of spontaneously hypertensive rat vascular smooth muscle cells.
Post-translational modification of L-PGDS, by either glycosylation or phosphorylation, enhances its apoptotic activity and inhibits vascular smooth muscle cells hyperproliferation.
Title: Post-translational modification regulates prostaglandin D2 synthase apoptotic activity: characterization by site-directed mutagenesis.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables prostaglandin-D synthase activity	ISO Inferred from Sequence Orthology more info
enables prostaglandin-D synthase activity	ISS Inferred from Sequence or Structural Similarity more info
enables prostaglandin-D synthase activity	TAS Traceable Author Statement more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of male germ cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin biosynthetic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within prostaglandin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to nematode	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to nematode	ISO Inferred from Sequence Orthology more info
involved_in response to selenium ion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to selenium ion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: hematopoietic prostaglandin D synthase

Names: GST class-sigma; H-PGDS; glutathione S-transferase; glutathione-dependent PGD synthase; glutathione-dependent PGD synthetase; glutathione-requiring prostaglandin D synthase; prostaglandin D2 synthase 2, hematopoietic; prostaglandin-H2 D-isomerase

NP_113832.1

EC 2.5.1.18

EC 5.3.99.2

XP_006236664.1

EC 2.5.1.18

EC 5.3.99.2

XP_006236665.1

EC 2.5.1.18

EC 5.3.99.2

XP_038964225.1

EC 2.5.1.18

EC 5.3.99.2

XP_063142720.1

EC 2.5.1.18

EC 5.3.99.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031644.2 → NP_113832.1 hematopoietic prostaglandin D synthase

See identical proteins and their annotated locations for NP_113832.1

Status: PROVISIONAL

Source sequence(s)

BC087590

UniProtKB/Swiss-Prot

O35351, O35543

UniProtKB/TrEMBL

A6KF23

Related

ENSRNOP00000008826.4, ENSRNOT00000008826.7

Conserved Domains (2) summary

cd10295
Location:82 → 181

GST_C_Sigma; C-terminal, alpha helical domain of Class Sigma Glutathione S-transferases

cd03039
Location:4 → 73

GST_N_Sigma_like; GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

95698265..95727733 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006236603.5 → XP_006236665.1 hematopoietic prostaglandin D synthase isoform X2

Conserved Domains (2) summary

cd10295
Location:51 → 151

GST_C_Sigma; C-terminal, alpha helical domain of Class Sigma Glutathione S-transferases

cd03039
Location:4 → 43

GST_N_Sigma_like; GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of ...
XM_006236602.5 → XP_006236664.1 hematopoietic prostaglandin D synthase isoform X1

Related

ENSRNOP00000106939.1, ENSRNOT00000123843.1

Conserved Domains (3) summary

PTZ00057
Location:3 → 198

PTZ00057; glutathione s-transferase; Provisional

cd10295
Location:82 → 182

GST_C_Sigma; C-terminal, alpha helical domain of Class Sigma Glutathione S-transferases

cd03039
Location:4 → 73

GST_N_Sigma_like; GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of ...
XM_063286650.1 → XP_063142720.1 hematopoietic prostaglandin D synthase isoform X3
XM_039108297.2 → XP_038964225.1 hematopoietic prostaglandin D synthase isoform X4

Conserved Domains (2) summary

cd03039
Location:4 → 73

GST_N_Sigma_like; GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of ...

cl02776
Location:82 → 145

GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family