Cela2a chymotrypsin like elastase 2A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cela2aprovided by RGD
Official Full Name: chymotrypsin like elastase 2Aprovided by RGD
Primary source: RGD:2548
See related: EnsemblRapid:ENSRNOG00000013628 AllianceGenome:RGD:2548
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ela2; ELAII; Ela2a; Elaii1
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in several processes, including insulin catabolic process; regulation of insulin secretion; and response to insulin. Predicted to be located in extracellular region and keratohyalin granule. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in abdominal obesity-metabolic syndrome 4. Orthologous to several human genes including CELA2A (chymotrypsin like elastase 2A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 5199.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (159409900..159420282, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (154126879..154136630, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (160374031..160383782, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Suggest that elastase-2 may contribute as an alternative pathway for ANG II generation when ACE is inhibited in the rat vascular tissue.
Title: Angiotensin-converting enzyme inhibition augments the expression of rat elastase-2, an angiotensin II-forming enzyme.
Analysis of rat mesenteric arterial bed elastase-2, expressed in mesenteric arteries and lung but not in aorta, reveals primary structural features that could contribute to the lack of activity of this enzyme toward angiotensin II.
Title: Molecular cloning and sequencing of the cDNA for rat mesenteric arterial bed elastase-2, an angiotensin II-forming enzyme.
the fact that cultured mesenteric arterial bed endothelial cells are capable of producing and secreting elastase-2 represent strong evidence of a physiological role for this enzyme in the rat vasculature.
Title: Functional role, cellular source, and tissue distribution of rat elastase-2, an angiotensin II-forming enzyme.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D5Arb14 (e-PCR), detects polymorphism
- UniSTS:227844

RH140695 (e-PCR)
- UniSTS:222762

RH142416 (e-PCR)
- UniSTS:231663

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables serine hydrolase activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in establishment of skin barrier	IEA Inferred from Electronic Annotation more info
involved_in insulin catabolic process	ISO Inferred from Sequence Orthology more info
involved_in insulin catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of insulin secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of platelet aggregation	ISO Inferred from Sequence Orthology more info
involved_in regulation of platelet aggregation	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to insulin	ISO Inferred from Sequence Orthology more info
involved_in response to insulin	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in keratohyalin granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: chymotrypsin-like elastase family member 2A

Names: Elastase 2, pancreatic; chymotrypsin-like elastase family, member 2A; elastase-2; elastase-2A

NP_036685.1

EC 3.4.21.71

XP_063143222.1

EC 3.4.21.71

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012553.2 → NP_036685.1 chymotrypsin-like elastase family member 2A precursor

See identical proteins and their annotated locations for NP_036685.1

Status: PROVISIONAL

Source sequence(s)

V01233

UniProtKB/Swiss-Prot

P00774

UniProtKB/TrEMBL

A6ITW9

Related

ENSRNOP00000018349.3, ENSRNOT00000018349.6

Conserved Domains (2) summary

smart00020
Location:30 → 264

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:31 → 267

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...