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    Ralb RAS like proto-oncogene B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116546, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ralbprovided by RGD
    Official Full Name
    RAS like proto-oncogene Bprovided by RGD
    Primary source
    RGD:619852
    See related
    EnsemblRapid:ENSRNOG00000002440 AllianceGenome:RGD:619852
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    dRalb
    Summary
    Predicted to enable GTPase activity; enzyme binding activity; and guanyl ribonucleotide binding activity. Involved in regulation of exocyst assembly and regulation of exocyst localization. Predicted to be located in midbody. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in pancreatic adenocarcinoma. Orthologous to human RALB (RAS like proto-oncogene B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 140.4), Lung (RPKM 127.3) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ralb in Genome Data Viewer
    Location:
    13q11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (33140834..33176997, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (30588036..30624199, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (35494716..35531503, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481619 Neighboring gene inhibin subunit beta B Neighboring gene U6 spliceosomal RNA Neighboring gene transmembrane protein 185B

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GDP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables GTP binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to exogenous dsRNA IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to exogenous dsRNA ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to starvation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to starvation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of autophagosome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epidermal growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor internalization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of exocyst assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of exocyst localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
     
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
     
    located_in midbody ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    ras-related protein Ral-B
    Names
    GTP binding protein)
    RALB Ras like proto-oncogene B
    v-ral simian leukemia viral oncogene homolog B (ras related)
    v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)
    NP_446273.1
    XP_038946195.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053821.2NP_446273.1  ras-related protein Ral-B

      See identical proteins and their annotated locations for NP_446273.1

      Status: PROVISIONAL

      Source sequence(s)
      BC072505
      UniProtKB/Swiss-Prot
      P36860
      UniProtKB/TrEMBL
      A6K7W8
      Related
      ENSRNOP00000087562.1, ENSRNOT00000096405.2
      Conserved Domains (1) summary
      cd04139
      Location:15178
      RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      33140834..33176997 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090267.2XP_038946195.1  ras-related protein Ral-B isoform X1

      UniProtKB/Swiss-Prot
      P36860
      UniProtKB/TrEMBL
      A6K7W8
      Conserved Domains (1) summary
      cd04139
      Location:15178
      RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB