Htr1d 5-hydroxytryptamine receptor 1D [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Htr1dprovided by RGD
Official Full Name: 5-hydroxytryptamine receptor 1Dprovided by RGD
Primary source: RGD:2847
See related: EnsemblRapid:ENSRNOG00000012038 AllianceGenome:RGD:2847
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: 5HT1D
Summary: Predicted to enable neurotransmitter receptor activity; serotonin binding activity; and transmembrane signaling receptor activity. Involved in regulation of synaptic vesicle exocytosis. Is active in glutamatergic synapse and neuronal dense core vesicle. Orthologous to human HTR1D (5-hydroxytryptamine receptor 1D). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 6.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (153939735..153960012)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (148656252..148676532)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (154780958..154801505)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The protective effect of alpha7-nACh receptor and its interaction with 5-HT1B/1D receptors in acute intestinal ischemia-reperfusion injury in rats.
Title: The protective effect of α7-nACh receptor and its interaction with 5-HT1B/1D receptors in acute intestinal ischemia-reperfusion injury in rats.
Involvement of 5-HT1B/1D receptors in the inflammatory response and oxidative stress in intestinal ischemia/reperfusion in rats.
Title: Involvement of 5-HT1B/1D receptors in the inflammatory response and oxidative stress in intestinal ischemia/reperfusion in rats.
5-HTB/D receptors have a role in the reduction of formalin-induced nociception and secondary allodynia/hyperalgesia produced by antimigraine drugs in rats.
Title: Role of 5-HT₁B/₁D receptors in the reduction of formalin-induced nociception and secondary allodynia/hyperalgesia produced by antimigraine drugs in rats.
NXN-188 inhibits CGRP release from migraine-relevant cephalic tissues.
Title: NXN-188, a selective nNOS inhibitor and a 5-HT1B/1D receptor agonist, inhibits CGRP release in preclinical migraine models.
The mRNA and protein expressions of 5-HT1D receptor decreased in excessive fatigue rats and restraint stress rats.
Title: [Effects of fatigue and restraint stress on the expression of carnitine palmitoyltransferase-I and 5-hydroxytryptamine receptors in aorta of rats].
5-HT(1B), 5-HT(1D)and 5-HT(1F) receptor expression are equally represented in trigeminal ganglia and the dorsal root ganglia.
Title: Distribution of 5-HT(1B), 5-HT(1D) and 5-HT(1F) receptor expression in rat trigeminal and dorsal root ganglia neurons: relevance to the selective anti-migraine effect of triptans.
vestibular ganglion cells were immunoreactive for 5-HT(1B) receptors in macaques and rats
Title: Distribution of 5-HT1B and 5-HT1D receptors in the inner ear.
Moreover, the widespread expression of 5-HT1D receptor in somatic nociceptive afferents suggests that triptans could, in certain circumstances, treat pain in nontrigeminal regions of the body.
Title: Tissue injury regulates serotonin 1D receptor expression: implications for the control of migraine and inflammatory pain.
Presynaptic 5-HT1D receptors could regulate the nitric oxide-evoked release of glutamate and subsequent cGMP production.
Title: Nitric oxide-evoked glutamate release and cGMP production in cerebellar slices: control by presynaptic 5-HT1D receptors.
Our finding, that 5-HT1D receptors are distributed in nociceptors throughout the body, raises the possibility that triptans can regulate not only headache-associated pain but also nociceptive responses in extracranial tissues
Title: Peptidergic nociceptors of both trigeminal and dorsal root ganglia express serotonin 1D receptors: implications for the selective antimigraine action of triptans.

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General gene information

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Markers

Htr1d (e-PCR), detects polymorphism
- UniSTS:143417

UniSTS:143418 (e-PCR)
- UniSTS:143418

Htr1d (e-PCR), detects polymorphism
- UniSTS:143418

RH132942 (e-PCR)
- UniSTS:216225

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled serotonin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled serotonin receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled serotonin receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables Gi/o-coupled serotonin receptor activity	ISO Inferred from Sequence Orthology more info
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serotonin binding	ISO Inferred from Sequence Orthology more info
enables serotonin receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in intestine smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of behavior	IEA Inferred from Electronic Annotation more info
involved_in regulation of locomotion	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic vesicle exocytosis	EXP Inferred from Experiment more info	PubMed
involved_in regulation of synaptic vesicle exocytosis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to toxic substance	ISO Inferred from Sequence Orthology more info
involved_in vasoconstriction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuronal dense core vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: 5-hydroxytryptamine receptor 1D

Names: 5 - Hydroxytryptamine (serotonin) receptor 1D; 5-HT-1D; 5-HT1D; 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled; serotonin receptor 1D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012852.2 → NP_036984.1 5-hydroxytryptamine receptor 1D

See identical proteins and their annotated locations for NP_036984.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P28565

UniProtKB/TrEMBL

A6ITB2

Related

ENSRNOP00000104073.1, ENSRNOT00000171476.1

Conserved Domains (1) summary

cd15333
Location:32 → 364

7tmA_5-HT1B_1D; serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors