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    Plek pleckstrin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 364206, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Plekprovided by RGD
    Official Full Name
    pleckstrinprovided by RGD
    Primary source
    RGD:1308269
    See related
    EnsemblRapid:ENSRNOG00000005214 AllianceGenome:RGD:1308269
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatidylinositol-3,4-bisphosphate binding activity; protein homodimerization activity; and protein kinase C binding activity. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; exocytosis; and positive regulation of cellular component organization. Predicted to be located in cytoplasm and ruffle membrane. Predicted to be active in plasma membrane. Orthologous to human PLEK (pleckstrin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 536.7), Lung (RPKM 107.4) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Plek in Genome Data Viewer
    Location:
    14q22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (95598650..95631326, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (91397015..91429693, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (100151518..100184192, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481789 Neighboring gene F-box protein 48 Neighboring gene uncharacterized LOC134481790 Neighboring gene uncharacterized LOC120096673 Neighboring gene cannabinoid receptor interacting protein 1 Neighboring gene protein phosphatase 3, regulatory subunit B, alpha Neighboring gene uncharacterized LOC134481791

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Loss of pleckstrin defines a novel pathway for PKC-mediated exocytosis. Lian L, et al. Blood, 2009 Apr 9. PMID 19190246, Free PMC Article
    2. Structure and phosphatidylinositol-(3,4)-bisphosphate binding of the C-terminal PH domain of human pleckstrin. Edlich C, et al. Structure, 2005 Feb. PMID 15698571
    3. Phosphorylated pleckstrin induces cell spreading via an integrin-dependent pathway. Roll RL, et al. J Cell Biol, 2000 Sep 18. PMID 10995449, Free PMC Article
    4. Pleckstrin induces cytoskeletal reorganization via a Rac-dependent pathway. Ma AD, et al. J Biol Chem, 1999 Oct 1. PMID 10497244
    5. Pleckstrin associates with plasma membranes and induces the formation of membrane projections: requirements for phosphorylation and the NH2-terminal PH domain. Ma AD, et al. J Cell Biol, 1997 Mar 10. PMID 9060471, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112902

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol-3,4-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase C binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell projection organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cortical actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of inositol phosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylinositol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipase C-inhibiting G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in platelet aggregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in platelet aggregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in platelet degranulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of actin filament bundle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of actin filament depolymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of actin filament depolymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of inositol-polyphosphate 5-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of integrin activation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of integrin activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of platelet activation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of platelet activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein secretion by platelet IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein secretion by platelet ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell diameter ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ruffle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in thrombin-activated receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thrombin-activated receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle docking involved in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle docking involved in exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pleckstrin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025750.1 → NP_001020921.1  pleckstrin

      See identical proteins and their annotated locations for NP_001020921.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098846
      UniProtKB/Swiss-Prot
      Q4KM33
      UniProtKB/TrEMBL
      A0A8I6ANN0, A6JPY3
      Related
      ENSRNOP00000007044.3, ENSRNOT00000007044.7
      Conserved Domains (4) summary
      cd04445
      Location:125 → 223
      DEP_PLEK1; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in pleckstrin 1-like proteins. Pleckstrin 1 plays a role in cell spreading and reorganization of actin cytoskeleton in platelets and leukocytes. Its activity is highly regulated by phosphorylation, ...
      cd13301
      Location:3 → 110
      PH1_Pleckstrin_2; Pleckstrin 2 Pleckstrin homology (PH) domain, repeat 1
      cd13302
      Location:239 → 346
      PH2_Pleckstrin_2; Pleckstrin 2 Pleckstrin homology (PH) domain, repeat 2
      pfam00169
      Location:6 → 101
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      95598650..95631326 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006251520.1 → XP_006251582.1  pleckstrin isoform X1

      See identical proteins and their annotated locations for XP_006251582.1

      UniProtKB/Swiss-Prot
      Q4KM33
      UniProtKB/TrEMBL
      A0A8I6ANN0, A6JPY3
      Related
      ENSRNOP00000083092.2, ENSRNOT00000094345.2
      Conserved Domains (4) summary
      cd04445
      Location:125 → 223
      DEP_PLEK1; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in pleckstrin 1-like proteins. Pleckstrin 1 plays a role in cell spreading and reorganization of actin cytoskeleton in platelets and leukocytes. Its activity is highly regulated by phosphorylation, ...
      cd13301
      Location:3 → 110
      PH1_Pleckstrin_2; Pleckstrin 2 Pleckstrin homology (PH) domain, repeat 1
      cd13302
      Location:239 → 346
      PH2_Pleckstrin_2; Pleckstrin 2 Pleckstrin homology (PH) domain, repeat 2
      pfam00169
      Location:6 → 101
      PH; PH domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4KM33.1 GenPept UniProtKB/Swiss-Prot:Q4KM33

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