Rad23a RAD23 homolog A, nucleotide excision repair protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rad23aprovided by RGD
Official Full Name: RAD23 homolog A, nucleotide excision repair proteinprovided by RGD
Primary source: RGD:1309899
See related: EnsemblRapid:ENSRNOG00000003026 AllianceGenome:RGD:1309899
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including enzyme binding activity; proteasome binding activity; and ubiquitin binding activity. Predicted to be involved in several processes, including positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of viral genome replication; and protein destabilization. Predicted to act upstream of or within DNA damage response. Predicted to be located in Golgi apparatus and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytosol and nucleoplasm. Orthologous to human RAD23A (RAD23 homolog A, nucleotide excision repair protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 292.7), Spleen (RPKM 265.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q11

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (40219235..40225543)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (23313563..23320702)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (25949488..25956677, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables damaged DNA binding	IEA Inferred from Electronic Annotation more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables polyubiquitin modification-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables polyubiquitin modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables proteasome binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-specific protease binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in nucleotide-excision repair	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein destabilization	ISO Inferred from Sequence Orthology more info
involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of proteasome complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: UV excision repair protein RAD23 homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013190.2 → NP_001013208.1 UV excision repair protein RAD23 homolog A isoform 1

See identical proteins and their annotated locations for NP_001013208.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

F7FJT3, Q5XFX7

Conserved Domains (4) summary

cd01805
Location:3 → 80

RAD23_N; Ubiquitin-like domain of RAD23

cd14377
Location:162 → 201

UBA1_Rad23; UBA1 domain of Rad23 proteins found in metazoa

TIGR00601
Location:3 → 325

rad23; UV excision repair protein Rad23

pfam09280
Location:231 → 286

XPC-binding; XPC-binding domain
NM_001399101.1 → NP_001386030.1 UV excision repair protein RAD23 homolog A isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

A6IY71, F7FJT3

Conserved Domains (1) summary

TIGR00601
Location:3 → 361

rad23; UV excision repair protein Rad23
NM_001399102.1 → NP_001386031.1 UV excision repair protein RAD23 homolog A isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

F7FJT3

Related

ENSRNOP00000004042.6, ENSRNOT00000004042.7

Conserved Domains (1) summary

TIGR00601
Location:3 → 360

rad23; UV excision repair protein Rad23

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

40219235..40225543

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008772411.4 → XP_008770633.1 UV excision repair protein RAD23 homolog A isoform X1

UniProtKB/TrEMBL

F7FJT3

Conserved Domains (4) summary

cd01805
Location:3 → 80

RAD23_N; Ubiquitin-like domain of RAD23

smart00213
Location:3 → 77

UBQ; Ubiquitin homologues

cd14377
Location:162 → 201

UBA1_Rad23; UBA1 domain of Rad23 proteins found in metazoa

pfam09280
Location:232 → 287

XPC-binding; XPC-binding domain