Vwa8 von Willebrand factor A domain containing 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Vwa8provided by RGD
Official Full Name: von Willebrand factor A domain containing 8provided by RGD
Primary source: RGD:1308772
See related: EnsemblRapid:ENSRNOG00000053145 AllianceGenome:RGD:1308772
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1308772
Summary: Predicted to enable ATP hydrolysis activity. Predicted to be located in mitochondrion and peroxisome. Orthologous to human VWA8 (von Willebrand factor A domain containing 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 326.9), Liver (RPKM 230.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15q11-q12

Exon count:: 47

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (60661764..60985971)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (54252703..54576871)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (61069439..61153292) , (61158510..61467462)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The vMTS is essential for localization to the mitochondrial matrix and that once there, VWA8 localizes to the matrix side of inner mitochondrial membrane.
Title: Von Willebrand factor A domain-containing protein 8 (VWA8) localizes to the matrix side of the inner mitochondrial membrane.

Submit: New GeneRIF Correction

General gene information

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Markers

RH143518 (e-PCR)
- UniSTS:232764

RH129773 (e-PCR)
- UniSTS:213065

D15Got65 (e-PCR)
- UniSTS:112463

RH130568 (e-PCR)
- UniSTS:213852

RH134704 (e-PCR)
- UniSTS:217982

BF390452 (e-PCR)
- UniSTS:249473

AW535983 (e-PCR)
- UniSTS:261051

Hars (e-PCR), detects polymorphism
- UniSTS:143316

AU048166 (e-PCR)
- UniSTS:109806

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: von Willebrand factor A domain-containing protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427283.1 → NP_001414212.1 von Willebrand factor A domain-containing protein 8

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/TrEMBL

A0A0G2K3W1

Related

ENSRNOP00000072799.2, ENSRNOT00000084333.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

60661764..60985971

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063274157.1 → XP_063130227.1 von Willebrand factor A domain-containing protein 8 isoform X1

Related

ENSRNOP00000104923.1, ENSRNOT00000170597.1
XM_039094044.2 → XP_038949972.1 von Willebrand factor A domain-containing protein 8 isoform X2

Conserved Domains (3) summary

COG5271
Location:68 → 750

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

pfam07728
Location:9 → 165

AAA_5; AAA domain (dynein-related subfamily)

cl00057
Location:1618 → 1807

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
XM_039094045.2 → XP_038949973.1 von Willebrand factor A domain-containing protein 8 isoform X3

Conserved Domains (2) summary

pfam07728
Location:112 → 259

AAA_5; AAA domain (dynein-related subfamily)

cl00057
Location:1050 → 1239

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
XM_063274158.1 → XP_063130228.1 von Willebrand factor A domain-containing protein 8 isoform X4