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    SGIP1 SH3GL interacting endocytic adaptor 1 [ Homo sapiens (human) ]

    Gene ID: 84251, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SGIP1provided by HGNC
    Official Full Name
    SH3GL interacting endocytic adaptor 1provided by HGNC
    Primary source
    HGNC:HGNC:25412
    See related
    Ensembl:ENSG00000118473 MIM:611540; AllianceGenome:HGNC:25412
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    SGIP1 functions as an endocytic protein that affects signaling by receptors in neuronal systems involved in energy homeostasis via its interaction with endophilins (see SH3GL3; MIM 603362) (Trevaskis et al., 2005 [PubMed 15919751] and Uezu et al., 2007 [PubMed 17626015]).[supplied by OMIM, Mar 2008]
    Expression
    Biased expression in brain (RPKM 8.0), endometrium (RPKM 2.4) and 11 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SGIP1 in Genome Data Viewer
    Location:
    1p31.3
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (66533361..66751139)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (66410946..66628673)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (66999044..67216822)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 4B Neighboring gene RNA, U4 small nuclear 88, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr1:66694092-66694275 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1146 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1147 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1148 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1149 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1150 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1151 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1152 Neighboring gene Sharpr-MPRA regulatory region 6178 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1153 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1154 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1155 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:66820269-66820769 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1158 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1157 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1156 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1159 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1160 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:66866019-66867218 Neighboring gene uncharacterized LOC105378776 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1164 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1165 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:66946325-66946955 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:66946956-66947585 Neighboring gene uncharacterized LOC124904196 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1166 Neighboring gene microRNA 3117 Neighboring gene dynein light chain Tctex-type family member 5 Neighboring gene insulin like 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Plasma SGIP1 methylation in diagnosis and prognosis prediction in hepatocellular carcinoma. Xie GF, et al. Neoplasma, 2021 Jan. PMID 33118832
    2. SGIP1 dimerizes via intermolecular disulfide bond in μHD domain during cellular endocytosis. Zhang Y, et al. Biochem Biophys Res Commun, 2018 Oct 20. PMID 30236986
    3. Event-related potentials (ERP) and SGIP1 gene polymorphisms in alcoholics: relation to family history of alcoholism and drug usage. Chwedorowicz R, et al. Ann Agric Environ Med, 2016 Dec 23. PMID 28030933
    4. Nonreplication of an association of SGIP1 SNPs with alcohol dependence and resting theta EEG power. Derringer J, et al. Psychiatr Genet, 2011 Oct. PMID 21317682, Free PMC Article
    5. Genetic variation in SH3-domain GRB2-like (endophilin)-interacting protein 1 has a major impact on fat mass. Cummings N, et al. Int J Obes (Lond), 2012 Feb. PMID 21407171

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Plasma SGIP1 methylation in diagnosis and prognosis prediction in hepatocellular carcinoma.
      Title: Plasma SGIP1 methylation in diagnosis and prognosis prediction in hepatocellular carcinoma.
    2. Data indicate that cysteine C632 residue is important for the function of SH3 domain GRB2 like endophilin interacting protein 1 (SGIP1) during cellular endocytosis.
      Title: SGIP1 dimerizes via intermolecular disulfide bond in μHD domain during cellular endocytosis.
    3. The present study demonstrated a possible association of target P300 evoked theta and of alcohol dependence with SNPs from the gene SGIP1 in the region of rs10889635, but further studies are required.
      Title: Event-related potentials (ERP) and SGIP1 gene polymorphisms in alcoholics: relation to family history of alcoholism and drug usage.
    4. crystal structures of the SGIP1 mu homology domains in complex with peptides containing two DPF motifs, are reported.
      Title: Structural basis for the recognition of two consecutive mutually interacting DPF motifs by the SGIP1 μ homology domain.
    5. Our results show association between genetic variants in SGIP1 and fat mass. We provide evidence that variation in SGIP1 is a potentially important determinant of obesity-related traits in humans
      Title: Genetic variation in SH3-domain GRB2-like (endophilin)-interacting protein 1 has a major impact on fat mass.
    6. The earlier implicated single nucleotide polymorphisms located in SGIP1 gene showed no association with alcohol dependence or theta electroencephalogram power.
      Title: Nonreplication of an association of SGIP1 SNPs with alcohol dependence and resting theta EEG power.
    7. SGIP1 and the signaling adaptor Reps1 interact with ITSN1 in vivo.
      Title: Intersectin 1 forms complexes with SGIP1 and Reps1 in clathrin-coated pits.
    8. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Genome-wide association identifies candidate genes that influence the human electroencephalogram.
    9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    10. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene variants associated with ischemic stroke: the cardiovascular health study.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study of early menopause and the combined impact of identified variants.
    EBI GWAS Catalog
    Genome-wide association study of antiphospholipid antibodies.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ33378, FLJ43054, DKFZp761D221, DKFZp686A16142

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SH3 domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phospholipid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in clathrin-dependent endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in energy homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of feeding behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of receptor-mediated endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to dietary excess ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in synaptic vesicle endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-2 adaptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in clathrin-coated pit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in clathrin-coated vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SH3-containing GRB2-like protein 3-interacting protein 1
    Names
    SH3 domain GRB2 like endophilin interacting protein 1
    endophilin-3-interacting protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308203.2 → NP_001295132.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001295132.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which has the same N- and C-termini, but has some distinct internal segments, is lacking other internal segments, and is shorter than isoform 1.
      Source sequence(s)
      AL136561, AL354978, AW205180, BC040516, BX640813
      Consensus CDS
      CCDS76171.1
      UniProtKB/TrEMBL
      A0A804HJI3
      Related
      ENSP00000360078.1, ENST00000371039.5
      Conserved Domains (1) summary
      cd09266
      Location:364 → 630
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    2. NM_001350217.2 → NP_001337146.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate in-frame exon in the 5' coding region, but also lacks an alternate exon in the 5' coding region, compared to variant 1. This variant encodes isoform 3, which has the same N- and C-termini, but is four aa longer than isoform 1.
      Source sequence(s)
      AB210039, AL136561, AL354978, AW205180, BC040516, DA491011
      UniProtKB/TrEMBL
      A0A804HJS7
      Related
      ENSP00000237247.6, ENST00000237247.10
      Conserved Domains (1) summary
      cd09266
      Location:565 → 831
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    3. NM_001350218.2 → NP_001337147.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons in the 5' coding region, compared to variant 1. This variant encodes isoform 4, which has the same N- and C-termini, but is shorter than isoform 1.
      Source sequence(s)
      AK299941, AL136561, AL354978, AW205180
      UniProtKB/TrEMBL
      B7Z5H8, B7Z691
      Conserved Domains (1) summary
      cd09266
      Location:370 → 636
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    4. NM_001376534.1 → NP_001363463.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL139147, AL354978, AL356913
      Consensus CDS
      CCDS30744.1
      UniProtKB/Swiss-Prot
      A6NL81, A6NLD1, Q4LE32, Q5VYE2, Q5VYE3, Q5VYE4, Q68D76, Q6MZY6, Q8IWC2, Q9BQI5
      UniProtKB/TrEMBL
      A0A804HHZ7
      Conserved Domains (1) summary
      cd09266
      Location:561 → 827
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    5. NM_001376535.1 → NP_001363464.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL139147, AL354978, AL356913
      Consensus CDS
      CCDS30744.1
      UniProtKB/Swiss-Prot
      A6NL81, A6NLD1, Q4LE32, Q5VYE2, Q5VYE3, Q5VYE4, Q68D76, Q6MZY6, Q8IWC2, Q9BQI5
      UniProtKB/TrEMBL
      A0A804HHZ7
      Conserved Domains (1) summary
      cd09266
      Location:561 → 827
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    6. NM_001376536.1 → NP_001363465.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL139147, AL354978, AL356913
      Consensus CDS
      CCDS76171.1
      UniProtKB/TrEMBL
      A0A804HJI3
      Related
      ENSP00000508234.1, ENST00000684664.1
      Conserved Domains (1) summary
      cd09266
      Location:364 → 630
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    7. NM_001376537.1 → NP_001363466.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL139147, AL354978, AL356913
      UniProtKB/TrEMBL
      A0A804HJJ5
      Conserved Domains (1) summary
      cd09266
      Location:559 → 825
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    8. NM_001376538.1 → NP_001363467.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL139147, AL354978, AL356913
      UniProtKB/TrEMBL
      A0A804HJS7
      Conserved Domains (1) summary
      cd09266
      Location:545 → 811
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    9. NM_001376539.1 → NP_001363468.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL139147, AL354978, AL356913
      UniProtKB/TrEMBL
      A0A804HHZ7
      Conserved Domains (1) summary
      cd09266
      Location:541 → 807
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    10. NM_001376540.1 → NP_001363469.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL139147, AL354978, AL356913
      UniProtKB/TrEMBL
      A0A804HHZ7
      Conserved Domains (1) summary
      cd09266
      Location:541 → 807
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    11. NM_001376541.1 → NP_001363470.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL139147, AL354978, AL356913
      UniProtKB/TrEMBL
      A0A804HJJ5
      Conserved Domains (1) summary
      cd09266
      Location:537 → 803
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    12. NM_001376542.1 → NP_001363471.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL139147, AL354978, AL356913
      UniProtKB/TrEMBL
      A0A804HJJ5
      Conserved Domains (1) summary
      cd09266
      Location:537 → 803
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    13. NM_001376543.1 → NP_001363472.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL139147, AL354978, AL356913
      UniProtKB/TrEMBL
      A0A804HJJ5
      Conserved Domains (1) summary
      cd09266
      Location:537 → 803
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    14. NM_001376544.1 → NP_001363473.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL139147, AL354978, AL356913
      UniProtKB/TrEMBL
      A0A804HJJ5
      Conserved Domains (1) summary
      cd09266
      Location:517 → 783
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    15. NM_001376545.1 → NP_001363474.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL139147, AL354978, AL356913
      UniProtKB/TrEMBL
      A0A804HJJ5
      Conserved Domains (1) summary
      cd09266
      Location:517 → 783
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    16. NM_001376546.1 → NP_001363475.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL139147, AL354978, AL356913
      UniProtKB/TrEMBL
      B7Z5H8
      Conserved Domains (1) summary
      cd09266
      Location:398 → 664
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    17. NM_001376547.1 → NP_001363476.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AL139147, AL354978, AL356913
      Consensus CDS
      CCDS90969.1
      UniProtKB/TrEMBL
      A0A804HJG4, A0A804HJI3
      Related
      ENSP00000507495.1, ENST00000684168.1
      Conserved Domains (1) summary
      cd09266
      Location:388 → 654
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    18. NM_001376548.1 → NP_001363477.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AL139147, AL354978, AL356913
      Consensus CDS
      CCDS90970.1
      UniProtKB/TrEMBL
      A0A804HHV6, A0A804HJI3
      Related
      ENSP00000507159.1, ENST00000684178.1
      Conserved Domains (1) summary
      cd09266
      Location:386 → 652
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    19. NM_001376549.1 → NP_001363478.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AL139147, AL354978, AL356913
      Consensus CDS
      CCDS90970.1
      UniProtKB/TrEMBL
      A0A804HHV6, A0A804HJI3
      Related
      ENSP00000506779.1, ENST00000682707.1
      Conserved Domains (1) summary
      cd09266
      Location:386 → 652
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    20. NM_001376550.1 → NP_001363479.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AL139147, AL354978, AL356913
      Consensus CDS
      CCDS90971.1
      UniProtKB/TrEMBL
      A0A804HJI3, A0A804HJX5
      Related
      ENSP00000507684.1, ENST00000681971.1
      Conserved Domains (1) summary
      cd09266
      Location:366 → 632
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    21. NM_001376551.1 → NP_001363480.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AL139147, AL354978, AL356913
      Consensus CDS
      CCDS90972.1
      UniProtKB/TrEMBL
      B7Z5H8
      Related
      ENSP00000507311.1, ENST00000684539.1
      Conserved Domains (1) summary
      cd09266
      Location:362 → 628
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    22. NM_001376552.1 → NP_001363481.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AL139147, AL354978, AL356913
      Consensus CDS
      CCDS90972.1
      UniProtKB/TrEMBL
      B7Z5H8
      Related
      ENSP00000507967.1, ENST00000683257.1
      Conserved Domains (1) summary
      cd09266
      Location:362 → 628
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    23. NM_001376554.1 → NP_001363483.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AL139147, AL354978, AL356913
      Consensus CDS
      CCDS90973.1
      UniProtKB/TrEMBL
      A0A804HI01, B7Z5H8
      Related
      ENSP00000395525.3, ENST00000435165.3
      Conserved Domains (1) summary
      cd09266
      Location:342 → 608
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    24. NM_001376555.1 → NP_001363484.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AL139147, AL354978, AL356913
      Consensus CDS
      CCDS90973.1
      UniProtKB/TrEMBL
      A0A804HI01, B7Z5H8
      Related
      ENSP00000506836.1, ENST00000682293.1
      Conserved Domains (1) summary
      cd09266
      Location:342 → 608
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    25. NM_001376556.1 → NP_001363485.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 16

      Status: VALIDATED

      Source sequence(s)
      AL139147, AL356913
      UniProtKB/TrEMBL
      A0A804HIX4
      Related
      ENSP00000506802.1, ENST00000684083.1

    26. NM_001376557.1 → NP_001363486.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 17

      Status: VALIDATED

      Source sequence(s)
      AL139147, AL356913
      UniProtKB/TrEMBL
      A0A804HJ90
      Related
      ENSP00000410439.2, ENST00000424320.6

    27. NM_032291.4 → NP_115667.2  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 1

      See identical proteins and their annotated locations for NP_115667.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AL136561, AL354978, AW205180, BC040516, DA491011
      Consensus CDS
      CCDS30744.1
      UniProtKB/Swiss-Prot
      A6NL81, A6NLD1, Q4LE32, Q5VYE2, Q5VYE3, Q5VYE4, Q68D76, Q6MZY6, Q8IWC2, Q9BQI5
      UniProtKB/TrEMBL
      A0A804HHZ7
      Related
      ENSP00000360076.3, ENST00000371037.9
      Conserved Domains (1) summary
      cd09266
      Location:561 → 827
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      66533361..66751139
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047432059.1 → XP_047288015.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X19

      UniProtKB/TrEMBL
      A0A804HJI3, A0A804HJX5

    2. XM_047432054.1 → XP_047288010.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X13

      UniProtKB/TrEMBL
      A0A804HHV6, A0A804HJI3

    3. XM_047432058.1 → XP_047288014.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X19

      UniProtKB/TrEMBL
      A0A804HJI3, A0A804HJX5

    4. XM_005271270.5 → XP_005271327.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X21

      See identical proteins and their annotated locations for XP_005271327.1

      UniProtKB/TrEMBL
      B7Z5H8
      Conserved Domains (1) summary
      cd09266
      Location:362 → 628
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    5. XM_017002506.2 → XP_016857995.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A804HHZ7

    6. XM_017002510.2 → XP_016857999.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A804HHZ7

    7. XM_017002524.2 → XP_016858013.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A804HJI3
      Conserved Domains (1) summary
      cd09266
      Location:408 → 674
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    8. XM_047432055.1 → XP_047288011.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X13

      UniProtKB/TrEMBL
      A0A804HHV6, A0A804HJI3

    9. XM_017002508.2 → XP_016857997.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A804HHZ7

    10. XM_047432052.1 → XP_047288008.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A804HHZ7
      Related
      ENSP00000506830.1, ENST00000683499.1

    11. XM_047432051.1 → XP_047288007.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A804HJJ5

    12. XM_017002516.2 → XP_016858005.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A804HJJ5
      Related
      ENSP00000508116.1, ENST00000682054.1
      Conserved Domains (1) summary
      cd09266
      Location:551 → 817
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    13. XM_017002528.2 → XP_016858017.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X15

      UniProtKB/TrEMBL
      B7Z5H8

    14. XM_047432061.1 → XP_047288017.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X22

      UniProtKB/TrEMBL
      A0A804HJ90
      Related
      ENSP00000507400.1, ENST00000683291.1

    15. XM_006710961.3 → XP_006711024.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X4

      See identical proteins and their annotated locations for XP_006711024.1

      UniProtKB/TrEMBL
      A0A804HJS7
      Conserved Domains (1) summary
      cd09266
      Location:567 → 833
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    16. XM_006710971.3 → XP_006711034.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X9

      See identical proteins and their annotated locations for XP_006711034.1

      UniProtKB/TrEMBL
      A0A804HJI3
      Conserved Domains (1) summary
      cd09266
      Location:400 → 666
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    17. XM_017002529.2 → XP_016858018.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X16

      UniProtKB/TrEMBL
      A0A804HJI3

    18. XM_006710973.3 → XP_006711036.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X11

      See identical proteins and their annotated locations for XP_006711036.1

      UniProtKB/TrEMBL
      A0A804HJI3
      Conserved Domains (1) summary
      cd09266
      Location:392 → 658
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    19. XM_047432053.1 → XP_047288009.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X12

      UniProtKB/TrEMBL
      B7Z5H8

    20. XM_047432057.1 → XP_047288013.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X18

      UniProtKB/TrEMBL
      A0A804HJI3

    21. XM_017002505.2 → XP_016857994.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A804HHZ7

    22. XM_017002507.2 → XP_016857996.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A804HHZ7

    23. XM_011542291.2 → XP_011540593.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X10

      See identical proteins and their annotated locations for XP_011540593.1

      UniProtKB/TrEMBL
      A0A804HJI3
      Conserved Domains (1) summary
      cd09266
      Location:393 → 659
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    24. XM_011542292.2 → XP_011540594.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X17

      See identical proteins and their annotated locations for XP_011540594.1

      UniProtKB/TrEMBL
      A0A804HJI3
      Conserved Domains (1) summary
      cd09266
      Location:373 → 639
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    25. XM_047432056.1 → XP_047288012.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X14

      UniProtKB/TrEMBL
      A0A804HJI3

    26. XM_047432060.1 → XP_047288016.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X20

      UniProtKB/TrEMBL
      A0A804HJI3

    27. XM_017002515.2 → XP_016858004.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A804HJJ5
      Related
      ENSP00000507528.1, ENST00000683581.1
      Conserved Domains (1) summary
      cd09266
      Location:551 → 817
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    RNA

    1. XR_007064415.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      66410946..66628673
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339159.1 → XP_054195134.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X19

      UniProtKB/TrEMBL
      A0A804HJI3, A0A804HJX5

    2. XM_054339152.1 → XP_054195127.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X13

      UniProtKB/TrEMBL
      A0A804HHV6, A0A804HJI3

    3. XM_054339162.1 → XP_054195137.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X21

      UniProtKB/TrEMBL
      B7Z5H8

    4. XM_054339138.1 → XP_054195113.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A804HHZ7

    5. XM_054339141.1 → XP_054195116.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A804HHZ7

    6. XM_054339147.1 → XP_054195122.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A804HJI3

    7. XM_054339153.1 → XP_054195128.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X13

      UniProtKB/TrEMBL
      A0A804HHV6, A0A804HJI3

    8. XM_054339140.1 → XP_054195115.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A804HHZ7

    9. XM_054339144.1 → XP_054195119.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A804HHZ7

    10. XM_054339143.1 → XP_054195118.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A804HJJ5

    11. XM_054339146.1 → XP_054195121.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A804HJJ5

    12. XM_054339155.1 → XP_054195130.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X15

      UniProtKB/TrEMBL
      B7Z5H8

    13. XM_054339163.1 → XP_054195138.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X22

      UniProtKB/TrEMBL
      A0A804HJ90

    14. XM_054339160.1 → XP_054195135.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X19

      UniProtKB/TrEMBL
      A0A804HJI3, A0A804HJX5

    15. XM_054339142.1 → XP_054195117.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A804HJS7

    16. XM_054339148.1 → XP_054195123.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X9

      UniProtKB/TrEMBL
      A0A804HJI3

    17. XM_054339156.1 → XP_054195131.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X16

      UniProtKB/TrEMBL
      A0A804HJI3

    18. XM_054339150.1 → XP_054195125.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X11

      UniProtKB/TrEMBL
      A0A804HJI3

    19. XM_054339151.1 → XP_054195126.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X12

      UniProtKB/TrEMBL
      B7Z5H8

    20. XM_054339158.1 → XP_054195133.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X18

      UniProtKB/TrEMBL
      A0A804HJI3

    21. XM_054339137.1 → XP_054195112.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A804HHZ7

    22. XM_054339139.1 → XP_054195114.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A804HHZ7

    23. XM_054339149.1 → XP_054195124.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X10

      UniProtKB/TrEMBL
      A0A804HJI3

    24. XM_054339157.1 → XP_054195132.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X17

      UniProtKB/TrEMBL
      A0A804HJI3

    25. XM_054339154.1 → XP_054195129.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X14

      UniProtKB/TrEMBL
      A0A804HJI3

    26. XM_054339161.1 → XP_054195136.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X20

      UniProtKB/TrEMBL
      A0A804HJI3

    27. XM_054339145.1 → XP_054195120.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A804HJJ5

    RNA

    1. XR_008486178.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BQI5.2 GenPept UniProtKB/Swiss-Prot:Q9BQI5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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