Nptx1 neuronal pentraxin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nptx1provided by RGD
Official Full Name: neuronal pentraxin 1provided by RGD
Primary source: RGD:628894
See related: EnsemblRapid:ENSRNOG00000003741 AllianceGenome:RGD:628894
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable metal ion binding activity. Involved in several processes, including mitochondrial fragmentation involved in apoptotic process; neurotransmitter receptor localization to postsynaptic specialization membrane; and postsynaptic density assembly. Is active in glutamatergic synapse and synaptic cleft. Human ortholog(s) of this gene implicated in autosomal dominant cerebellar ataxia. Orthologous to human NPTX1 (neuronal pentraxin 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 209.4) and Lung (RPKM 10.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (105309578..105318829, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (104811107..104820358, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (108682637..108691592, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-139-5p mediates the palmitate-induced inhibition of insulin secretion by targeting neuronal pentraxin 1 in INS-1 cells.
Title: miR-139-5p mediates the palmitate-induced inhibition of insulin secretion by targeting neuronal pentraxin 1 in INS-1 cells.
Data indicate that expression of neuronal pentraxin 1 (NP1) in insulinoma INS-1E cells in insulin-secreting cells is modulated by high glucose and that NP1 in INS-1E cells is linked to the AKT/GSK3 pathway.
Title: Modulation of neuronal pentraxin 1 expression in rat pancreatic β-cells submitted to chronic glucotoxic stress.
Rescue of NP1 expression in the rostral ventromedial medulla (RVM) restores behavioral hypersensitivity of knock-out mice, demonstrating a key role of NP1 in the pathogenesis of neuropathic pain.
Title: Alleviation of neuropathic pain hypersensitivity by inhibiting neuronal pentraxin 1 in the rostral ventromedial medulla.
Our results show that neuronal pentraxin 1 induction mediates hypoxic-ischemic injury probably by interacting with and modulating GluR1 and potentially other excitatory glutamate receptors
Title: Neuronal pentraxin 1: a novel mediator of hypoxic-ischemic injury in neonatal brain.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH143293 (e-PCR)
- UniSTS:232540

Nptx1 (e-PCR), detects polymorphism
- UniSTS:144063

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axonogenesis involved in innervation	IBA Inferred from Biological aspect of Ancestor more info
involved_in axonogenesis involved in innervation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axonogenesis involved in innervation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to potassium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in mitochondrial fragmentation involved in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	EXP Inferred from Experiment more info	PubMed
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in postsynaptic density assembly	EXP Inferred from Experiment more info	PubMed
involved_in postsynaptic density assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic density assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in synaptic cleft	IDA Inferred from Direct Assay more info	PubMed
located_in transport vesicle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neuronal pentraxin-1

Names: 47 kDa taipoxin-binding protein; NP-I; NP1; neuronal pentraxin I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153735.4 → NP_714957.1 neuronal pentraxin-1 precursor

See identical proteins and their annotated locations for NP_714957.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

P47971

UniProtKB/TrEMBL

A0A0H2UHC1, A6HL92

Related

ENSRNOP00000005067.7, ENSRNOT00000005067.8

Conserved Domains (2) summary

smart00159
Location:222 → 428

PTX; Pentraxin / C-reactive protein / pentaxin family

COG1196
Location:52 → 221

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]