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    Cadps2 calcium dependent secretion activator 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312166, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cadps2provided by RGD
    Official Full Name
    calcium dependent secretion activator 2provided by RGD
    Primary source
    RGD:1559440
    See related
    EnsemblRapid:ENSRNOG00000007636 AllianceGenome:RGD:1559440
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1559440
    Summary
    Predicted to be involved in exocytosis and positive regulation of exocytosis. Predicted to act upstream of or within cellular response to starvation; hematopoietic stem cell homeostasis; and synaptic vesicle priming. Predicted to be located in cytoplasmic vesicle; nucleoplasm; and synaptic membrane. Predicted to be active in glutamatergic synapse; parallel fiber to Purkinje cell synapse; and presynapse. Orthologous to human CADPS2 (calcium dependent secretion activator 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 327.6), Lung (RPKM 69.6) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cadps2 in Genome Data Viewer
    Location:
    4q22
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (52746054..53275252, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (51780415..52309641, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (50326447..50861161, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486670 Neighboring gene uncharacterized LOC134486742 Neighboring gene Fez family zinc finger 1 Neighboring gene uncharacterized LOC134486740 Neighboring gene ring finger protein 133 Neighboring gene ring finger protein 148 Neighboring gene uncharacterized LOC108350675 Neighboring gene taste receptor, type 2, member 118 Neighboring gene solute carrier family 13 member 1 Neighboring gene thyroid hormone receptor associated protein 3, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Secretory vesicle priming by CAPS is independent of its SNARE-binding MUN domain. Nguyen Truong CQ, et al. Cell Rep, 2014 Nov 6. PMID 25437547
    2. Survival adjustment of mature dendritic cells by IL-15. Dubois SP, et al. Proc Natl Acad Sci U S A, 2005 Jun 14. PMID 15932944, Free PMC Article
    3. The secretory granule-associated protein CAPS2 regulates neurotrophin release and cell survival. Sadakata T, et al. J Neurosci, 2004 Jan 7. PMID 14715936, Free PMC Article
    4. The morphological and molecular nature of synaptic vesicle priming at presynaptic active zones. Imig C, et al. Neuron, 2014 Oct 22. PMID 25374362
    5. SNARE protein recycling by αSNAP and βSNAP supports synaptic vesicle priming. Burgalossi A, et al. Neuron, 2010 Nov 4. PMID 21040848

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dense core granule exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within hematopoietic stem cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within synaptic vesicle priming ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic vesicle priming ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in parallel fiber to Purkinje cell synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    calcium-dependent secretion activator 2
    Names
    Ca++-dependent secretion activator 2
    Ca2+ dependent secretion activator 2
    Ca2+-dependent activator protein for secretion 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427791.1 → NP_001414720.1  calcium-dependent secretion activator 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6ASE4
      Related
      ENSRNOP00000085438.2, ENSRNOT00000117045.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      52746054..53275252 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285976.1 → XP_063142046.1  calcium-dependent secretion activator 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6ASE4

    2. XM_039108614.2 → XP_038964542.1  calcium-dependent secretion activator 2 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZKA3
      Conserved Domains (3) summary
      smart00239
      Location:369 → 452
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:485 → 604
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:802 → 892
      DUF1041; Domain of Unknown Function (DUF1041)

    3. XM_002729291.6 → XP_002729337.1  calcium-dependent secretion activator 2 isoform X7

      See identical proteins and their annotated locations for XP_002729337.1

      UniProtKB/TrEMBL
      A0A8I5ZKA3
      Related
      ENSRNOP00000080739.2, ENSRNOT00000119022.2
      Conserved Domains (4) summary
      smart00239
      Location:369 → 452
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:485 → 604
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:493 → 592
      PH; PH domain
      pfam06292
      Location:802 → 892
      DUF1041; Domain of Unknown Function (DUF1041)

    4. XM_063285979.1 → XP_063142049.1  calcium-dependent secretion activator 2 isoform X10

      UniProtKB/TrEMBL
      A0A8I5Y244

    5. XM_063285975.1 → XP_063142045.1  calcium-dependent secretion activator 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I5Y244, A0A8I6AHC2
      Related
      ENSRNOP00000077855.2, ENSRNOT00000119282.2

    6. XM_063285977.1 → XP_063142047.1  calcium-dependent secretion activator 2 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZKA3

    7. XM_063285973.1 → XP_063142043.1  calcium-dependent secretion activator 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ASE4

    8. XM_039108612.2 → XP_038964540.1  calcium-dependent secretion activator 2 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZKA3
      Conserved Domains (3) summary
      smart00239
      Location:369 → 452
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:485 → 604
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:802 → 899
      DUF1041; Domain of Unknown Function (DUF1041)

    9. XM_063285974.1 → XP_063142044.1  calcium-dependent secretion activator 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ASE4, A0A8I6GDI0, A6IE75
      Related
      ENSRNOP00000097144.2, ENSRNOT00000108432.2

    10. XM_063285978.1 → XP_063142048.1  calcium-dependent secretion activator 2 isoform X9

      UniProtKB/TrEMBL
      A0A8I6ASE4
    Nucleotide Protein Strain
    Heading Accession and Version

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