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    Rabep2 rabaptin, RAB GTPase binding effector protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 80754, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rabep2provided by RGD
    Official Full Name
    rabaptin, RAB GTPase binding effector protein 2provided by RGD
    Primary source
    RGD:621416
    See related
    EnsemblRapid:ENSRNOG00000018462 AllianceGenome:RGD:621416
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fra; MP13
    Summary
    Predicted to enable GTPase activator activity and growth factor activity. Predicted to be involved in regulation of cilium assembly. Predicted to be located in centrosome; ciliary basal body; and cytosol. Predicted to be active in intracellular membrane-bounded organelle. Biomarker of cocaine dependence and nicotine dependence. Orthologous to human RABEP2 (rabaptin, RAB GTPase binding effector protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 135.3), Testes (RPKM 133.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rabep2 in Genome Data Viewer
    Location:
    1q36
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (190433501..190457241)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (181010305..181026651)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (197839583..197855953)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L36 like 3 Neighboring gene CD19 molecule Neighboring gene ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 Neighboring gene SH2B adaptor protein 1 Neighboring gene Tu translation elongation factor, mitochondrial

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Decreased expression of fos-related antigens (FRAs) in the hypothalamic dopaminergic neurons after immunoneutralization of endogenous prolactin. Lerant AA, et al. Endocrine, 2001 Dec. PMID 11954661
    2. Cloning and expression of MP13 gene from rat hippocampus, a new factor related to guanosine triphosphate regulation. Feng Z, et al. Neurosci Lett, 2000 Dec 22. PMID 11108998
    3. Nuclear translocation of STAT5 and increased expression of Fos related antigens (FRAs) in hypothalamic dopaminergic neurons after prolactin administration. Lerant A, et al. Brain Res, 2001 Jun 22. PMID 11406124
    4. Neural substrate of nicotine addiction as defined by functional brain maps of gene expression. Pich EM, et al. J Physiol Paris, 1998 Jun-Aug. PMID 9789813
    5. Fos-related antigen 2 controls protein kinase A-induced CCAAT/enhancer-binding protein beta expression in osteoblasts. Chang W, et al. J Biol Chem, 2004 Oct 8. PMID 15299028

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fos-related antigen 2 has a role in controlling protein kinase A-induced CCAAT/enhancer-binding protein beta expression in osteoblasts
      Title: Fos-related antigen 2 controls protein kinase A-induced CCAAT/enhancer-binding protein beta expression in osteoblasts.
    2. effect of immunoneutralization of endogenous prolactin on expression of FRAs in the tuberoinfundibular dopaminergic, tuberohypophysial dopaminergic and periventricular hypothalamic dopaminergic subpopulations of the hypothalamic dopaminergic neurons
      Title: Decreased expression of fos-related antigens (FRAs) in the hypothalamic dopaminergic neurons after immunoneutralization of endogenous prolactin.
    3. Expression of Fos-related antigens is an indicator of neuronal activation in hypothalamic dopaminergic neurons after prolactin administration.
      Title: Nuclear translocation of STAT5 and increased expression of Fos related antigens (FRAs) in hypothalamic dopaminergic neurons after prolactin administration.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cilium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary basal body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rab GTPase-binding effector protein 2
    Names
    Fos-related antigen
    rabaptin-5beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030585.2 → NP_085074.2  rab GTPase-binding effector protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q62835
      UniProtKB/TrEMBL
      F1LQC4, Q5EBC7
      Related
      ENSRNOP00000025043.6, ENSRNOT00000025043.9
      Conserved Domains (2) summary
      pfam03528
      Location:26 → 168
      Rabaptin
      pfam09311
      Location:276 → 531
      Rab5-bind; Rabaptin-like protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      190433501..190457241
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274956.1 → XP_063131026.1  rab GTPase-binding effector protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q62835
      UniProtKB/TrEMBL
      A6I951

    2. XM_039091811.2 → XP_038947739.1  rab GTPase-binding effector protein 2 isoform X2

      UniProtKB/TrEMBL
      A6I955
      Conserved Domains (1) summary
      pfam09311
      Location:131 → 386
      Rab5-bind; Rabaptin-like protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62835.1 GenPept UniProtKB/Swiss-Prot:Q62835

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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