Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Itpr1provided by RGD
Official Full Name: inositol 1,4,5-trisphosphate receptor, type 1provided by RGD
Primary source: RGD:2933
See related: EnsemblRapid:ENSRNOG00000007104 AllianceGenome:RGD:2933
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: P400; IP3R1; I145TR; InsP3R; InsP3R1
Summary: This gene belongs to the Insp3 receptor family. It encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
Expression: Biased expression in Brain (RPKM 805.4), Kidney (RPKM 503.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q41

Exon count:: 62

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (142743401..143066505)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (141187377..141554240)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (140247297..140580749)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of Ca[2+] signalling and InsP3R in the pathogenesis of intrahepatic cholestasis of pregnancy.
Title: The role of Ca(2+) signalling and InsP3R in the pathogenesis of intrahepatic cholestasis of pregnancy.
IP3R1-mediated MAMs formation contributes to mechanical trauma-induced hepatic injury and the protective effect of melatonin.
Title: IP(3)R1-mediated MAMs formation contributes to mechanical trauma-induced hepatic injury and the protective effect of melatonin.
Regulation of Hepatic Lipid and Glucose Metabolism by INSP3R1.
Title: Regulation of Hepatic Lipid and Glucose Metabolism by INSP3R1.
Ryanodine receptor-mediated Ca(2+) release and atlastin-2 GTPase activity contribute to IP3-induced dendritic Ca(2+) signals in primary hippocampal neurons.
Title: Ryanodine receptor-mediated Ca(2+) release and atlastin-2 GTPase activity contribute to IP(3)-induced dendritic Ca(2+) signals in primary hippocampal neurons.
Cryo-EM structure of type 1 IP3R channel in a lipid bilayer.
Title: Cryo-EM structure of type 1 IP(3)R channel in a lipid bilayer.
The authors present the electron cryo-microscopy structure of InsP3R1 from rat cerebellum determined to 4.1 A resolution in the presence of activating concentrations of Ca(2+) and adenophostin A (AdA).
Title: Cryo-EM reveals ligand induced allostery underlying InsP(3)R channel gating.
IP3RI protein expression is increased in the kidney of hepatorenal syndrome rats, and may be regulated at the transcriptional level.
Title: High expression of type I inositol 1,4,5-trisphosphate receptor in the kidney of rats with hepatorenal syndrome.
These findings highlight previously unidentified functions for IP3R isoforms in the heart with specific implications for hypertrophic signaling in animal models and in human disease.
Title: Functionally redundant control of cardiac hypertrophic signaling by inositol 1,4,5-trisphosphate receptors.
Data suggest that proteolytic processing of Itpr1 may represent a novel form of modulation of Itpr1 channel function and increases the repertoire of Ca2+ and PKA (protein kinase A) signaling achievable through inositol 1,4,5-trisphosphate/Itpr1 signal transduction.
Title: Region-specific proteolysis differentially regulates type 1 inositol 1,4,5-trisphosphate receptor activity.
Our findings indicate that sustained SOCC activity, together with that of the sarco-endoplasmic reticulum Ca(2+)-ATPase, contribute to the maintenance of astrocytic Ca(2+) store levels, ultimately enabling astrocytic Ca(2+) signaling.
Title: Astroglial Ca(2+) signaling is generated by the coordination of IP(3)R and store-operated Ca(2+) channels.

Submit: New GeneRIF Correction See all GeneRIFs (65)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH140203 (e-PCR)
- UniSTS:222282

D4RAT195 (e-PCR)
- UniSTS:121984

AU048843 (e-PCR)
- UniSTS:145293

D4Rat196 (e-PCR), detects polymorphism
- UniSTS:227749

RH133754 (e-PCR)
- UniSTS:217037

RH94529 (e-PCR)
- UniSTS:119777

AU028673 (e-PCR)
- UniSTS:112098

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium channel inhibitor activity	IEA Inferred from Electronic Annotation more info
enables calcium channel inhibitor activity	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables inositol 1,4,5 trisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables inositol 1,4,5 trisphosphate binding	IEA Inferred from Electronic Annotation more info
enables inositol 1,4,5 trisphosphate binding	ISO Inferred from Sequence Orthology more info
enables inositol 1,4,5 trisphosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels	IEA Inferred from Electronic Annotation more info
enables inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels	ISO Inferred from Sequence Orthology more info
enables inositol 1,4,5-trisphosphate-gated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol 1,4,5-trisphosphate-gated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol 1,4,5-trisphosphate-gated calcium channel activity	IEA Inferred from Electronic Annotation more info
enables inositol 1,4,5-trisphosphate-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables inositol 1,4,5-trisphosphate-gated calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables intracellularly gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables intracellularly gated calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	IDA Inferred from Direct Assay more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium import into the mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in cell morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cAMP	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in dendrite development	IEP Inferred from Expression Pattern more info	PubMed
involved_in endoplasmic reticulum calcium ion homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endoplasmic reticulum calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in epithelial fluid transport	IEA Inferred from Electronic Annotation more info
involved_in epithelial fluid transport	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IEA Inferred from Electronic Annotation more info
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in ion channel modulating, G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ion channel modulating, G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ligand-gated ion channel signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ligand-gated ion channel signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in liver regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hepatocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein homotetramerization	IEA Inferred from Electronic Annotation more info
involved_in protein homotetramerization	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytosolic calcium ion concentration	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of postsynaptic cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in release of sequestered calcium ion into cytosol	IBA Inferred from Biological aspect of Ancestor more info
involved_in release of sequestered calcium ion into cytosol	IEA Inferred from Electronic Annotation more info
involved_in release of sequestered calcium ion into cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in release of sequestered calcium ion into cytosol by endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
involved_in release of sequestered calcium ion into cytosol by endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
involved_in release of sequestered calcium ion into cytosol by endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in single fertilization	IEA Inferred from Electronic Annotation more info
involved_in single fertilization	ISO Inferred from Sequence Orthology more info
involved_in single fertilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in voluntary musculoskeletal movement	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within voluntary musculoskeletal movement	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
part_of calcineurin complex	IEA Inferred from Electronic Annotation more info
part_of calcineurin complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
is_active_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear inner membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear inner membrane	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in platelet dense granule membrane	IEA Inferred from Electronic Annotation more info
located_in platelet dense granule membrane	ISO Inferred from Sequence Orthology more info
located_in platelet dense tubular network	IEA Inferred from Electronic Annotation more info
located_in platelet dense tubular network	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
is_active_in sarcoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in sarcoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in secretory granule membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in smooth endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	ISO Inferred from Sequence Orthology more info
located_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in transport vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: inositol 1,4,5-trisphosphate-gated calcium channel ITPR1; inositol 1,4,5-trisphosphate receptor type 1

Names: IP-3-R; IP3 receptor; IP3R 1; inositol 1,4,5-triphosphate receptor 1; inositol 1,4,5-triphosphate receptor, type 1; type 1 InsP3 receptor; type 1 inositol 1,4,5-trisphosphate receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007235.2 → NP_001007236.2 inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 isoform 1

See identical proteins and their annotated locations for NP_001007236.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

BC091346, BF402715, GQ233032, J05510

UniProtKB/Swiss-Prot

P29994, Q62869

UniProtKB/TrEMBL

C7E1V2, F1LQS8

Conserved Domains (6) summary

smart00472
Location:231 → 287

MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases

pfam00520
Location:2340 → 2599

Ion_trans; Ion transport protein

pfam01365
Location:476 → 665

RYDR_ITPR; RIH domain

pfam02815
Location:232 → 433

MIR; MIR domain

pfam08454
Location:1963 → 2068

RIH_assoc; RyR and IP3R Homology associated

pfam08709
Location:4 → 225

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
NM_001270596.1 → NP_001257525.1 inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.

Source sequence(s)

BC091346, BF402715, GQ233032, J05510

UniProtKB/Swiss-Prot

P29994, Q62869

Related

ENSRNOP00000111175.1, ENSRNOT00000151720.1

Conserved Domains (6) summary

smart00472
Location:231 → 287

MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases

pfam00520
Location:2325 → 2584

Ion_trans; Ion transport protein

pfam01365
Location:461 → 650

RYDR_ITPR; RIH domain

pfam02815
Location:232 → 418

MIR; MIR domain

pfam08454
Location:1948 → 2053

RIH_assoc; RyR and IP3R Homology associated

pfam08709
Location:4 → 225

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
NM_001270597.1 → NP_001257526.1 inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks three consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. The resulting isoform (3) lacks an internal segment, compared to isoform 1.

Source sequence(s)

BC091346, BF402715, GQ233032, J05510, U38653

UniProtKB/TrEMBL

A0A0A0MY31

Related

ENSRNOP00000048661.5, ENSRNOT00000043646.6

Conserved Domains (6) summary

smart00472
Location:231 → 287

MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases

pfam00520
Location:2301 → 2560

Ion_trans; Ion transport protein

pfam01365
Location:476 → 665

RYDR_ITPR; RIH domain

pfam02815
Location:232 → 433

MIR; MIR domain

pfam08454
Location:1924 → 2029

RIH_assoc; RyR and IP3R Homology associated

pfam08709
Location:4 → 225

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor