Epha3 Eph receptor A3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Epha3provided by RGD
Official Full Name: Eph receptor A3provided by RGD
Primary source: RGD:68389
See related: EnsemblRapid:ENSRNOG00000030285 AllianceGenome:RGD:68389
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable GPI-linked ephrin receptor activity; growth factor binding activity; and transmembrane-ephrin receptor activity. Involved in cellular response to interleukin-1; fever generation; and response to lipopolysaccharide. Predicted to be located in several cellular components, including actin cytoskeleton; early endosome; and nucleus. Predicted to be active in several cellular components, including GABA-ergic synapse; dendrite; and presynapse. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human EPHA3 (EPH receptor A3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 29.7), Heart (RPKM 26.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11p12

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (14585041..14920721, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (1138485..1474102, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (421253..783037, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EphA3 promotes malignant transformation of colorectal epithelial cells by upregulating oncogenic signaling pathways.
Title: EphA3 promotes malignant transformation of colorectal epithelial cells by upregulating oncogenic pathways.
We examined the expression profile of EphA3 after SCI. There is a differential distribution of this molecule in the adult spinal cord and EphA3 showed an increase in expression after several injury models like optic nerve and brain injury.
Title: Upregulation of EphA3 receptor after spinal cord injury.

Submit: New GeneRIF Correction

General gene information

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Markers

UniSTS:498373 (e-PCR)
- UniSTS:498373

Epha3 (e-PCR), detects polymorphism
- UniSTS:498373

Epha3 (e-PCR), detects polymorphism
- UniSTS:266986

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GPI-linked ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables GPI-linked ephrin receptor activity	ISO Inferred from Sequence Orthology more info
enables GPI-linked ephrin receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables boss receptor activity	IEA Inferred from Electronic Annotation more info
enables brain-derived neurotrophic factor receptor activity	IEA Inferred from Electronic Annotation more info
enables ephrin receptor activity	ISO Inferred from Sequence Orthology more info
enables epidermal growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables growth factor binding	ISO Inferred from Sequence Orthology more info
enables hepatocyte growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables insulin receptor activity	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables macrophage colony-stimulating factor receptor activity	IEA Inferred from Electronic Annotation more info
enables placental growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor alpha-receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor beta-receptor activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase collagen receptor activity	IEA Inferred from Electronic Annotation more info
enables stem cell factor receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane-ephrin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane-ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables vascular endothelial growth factor receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Kit signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in brain-derived neurotrophic factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cellular response to follicle-stimulating hormone stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-1	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to retinoic acid	IEA Inferred from Electronic Annotation more info
involved_in cellular response to retinoic acid	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in collagen-activated tyrosine kinase receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in endocardial cushion development	ISO Inferred from Sequence Orthology more info
involved_in ephrin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ephrin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ephrin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ephrin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in fasciculation of motor neuron axon	ISO Inferred from Sequence Orthology more info
involved_in fasciculation of motor neuron axon	ISS Inferred from Sequence or Structural Similarity more info
involved_in fasciculation of sensory neuron axon	ISO Inferred from Sequence Orthology more info
involved_in fasciculation of sensory neuron axon	ISS Inferred from Sequence or Structural Similarity more info
involved_in fever generation	IEP Inferred from Expression Pattern more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in hepatocyte growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in macrophage colony-stimulating factor signaling pathway	IEA Inferred from Electronic Annotation more info
NOT involved_in motor neuron axon guidance	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endocytosis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of endocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in platelet-derived growth factor receptor-alpha signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in platelet-derived growth factor receptor-beta signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in regulation of epithelial to mesenchymal transition	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of focal adhesion assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of focal adhesion assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in synaptic membrane adhesion	ISO Inferred from Sequence Orthology more info
involved_in vascular endothelial growth factor receptor-1 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ephrin type-A receptor 3

Names: EK4; EPH-like kinase 4; rEK4; tyrosine-protein kinase TYRO4; tyrosine-protein kinase receptor REK4

NP_113752.2

EC 2.7.10.1

XP_006248038.1

EC 2.7.10.1

XP_006248039.1

EC 2.7.10.1

XP_038944162.1

EC 2.7.10.1

XP_038944163.1

EC 2.7.10.1

XP_038944164.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031564.2 → NP_113752.2 ephrin type-A receptor 3 precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000011

UniProtKB/Swiss-Prot

O08680

UniProtKB/TrEMBL

A6K4V7, G3V9D5

Related

ENSRNOP00000107600.1, ENSRNOT00000122837.1

Conserved Domains (6) summary

cd09544
Location:913 → 975

SAM_EPH-A3; SAM domain of EPH-A3 subfamily of tyrosine kinase receptors

cd10481
Location:29 → 201

EphR_LBD_A3; Ligand Binding Domain of Ephrin type-A Receptor 3

cd00063
Location:437 → 528

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05066
Location:617 → 883

PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors

pfam00041
Location:327 → 417

fn3; Fibronectin type III domain

pfam14575
Location:565 → 619

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

14585041..14920721 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006247976.5 → XP_006248038.1 ephrin type-A receptor 3 isoform X1

UniProtKB/Swiss-Prot

O08680

Conserved Domains (8) summary

cd09544
Location:912 → 974

SAM_EPH-A3; SAM domain of EPH-A3 subfamily of tyrosine kinase receptors

smart00454
Location:908 → 975

SAM; Sterile alpha motif

cd10481
Location:29 → 201

EphR_LBD_A3; Ligand Binding Domain of Ephrin type-A Receptor 3

cd00063
Location:437 → 527

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05066
Location:616 → 882

PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors

pfam00041
Location:327 → 417

fn3; Fibronectin type III domain

pfam07714
Location:621 → 878

Pkinase_Tyr; Protein tyrosine kinase

pfam14575
Location:565 → 616

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
XM_039088234.2 → XP_038944162.1 ephrin type-A receptor 3 isoform X3

UniProtKB/Swiss-Prot

O08680

Related

ENSRNOP00000043263.3, ENSRNOT00000040065.4

Conserved Domains (5) summary

cd09544
Location:871 → 933

SAM_EPH-A3; SAM domain of EPH-A3 subfamily of tyrosine kinase receptors

cd10481
Location:29 → 201

EphR_LBD_A3; Ligand Binding Domain of Ephrin type-A Receptor 3

cd00063
Location:437 → 528

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05066
Location:587 → 841

PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors

pfam00041
Location:327 → 417

fn3; Fibronectin type III domain
XM_006247977.5 → XP_006248039.1 ephrin type-A receptor 3 isoform X2

UniProtKB/Swiss-Prot

O08680

UniProtKB/TrEMBL

A0A0G2JT71

Related

ENSRNOP00000068593.1, ENSRNOT00000090197.3

Conserved Domains (8) summary

cd09544
Location:910 → 972

SAM_EPH-A3; SAM domain of EPH-A3 subfamily of tyrosine kinase receptors

smart00454
Location:906 → 973

SAM; Sterile alpha motif

cd10481
Location:27 → 198

EphR_LBD_A3; Ligand Binding Domain of Ephrin type-A Receptor 3

cd00063
Location:434 → 525

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05066
Location:614 → 880

PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors

pfam00041
Location:324 → 414

fn3; Fibronectin type III domain

pfam07714
Location:619 → 876

Pkinase_Tyr; Protein tyrosine kinase

pfam14575
Location:563 → 614

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
XM_039088235.2 → XP_038944163.1 ephrin type-A receptor 3 isoform X4

UniProtKB/Swiss-Prot

O08680

Conserved Domains (6) summary

cd09544
Location:840 → 902

SAM_EPH-A3; SAM domain of EPH-A3 subfamily of tyrosine kinase receptors

cd00063
Location:364 → 455

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05066
Location:544 → 810

PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors

pfam00041
Location:254 → 344

fn3; Fibronectin type III domain

pfam14575
Location:492 → 546

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

cl02704
Location:1 → 128

EphR_LBD; Ligand Binding Domain of Ephrin Receptors
XM_039088236.2 → XP_038944164.1 ephrin type-A receptor 3 isoform X4

UniProtKB/Swiss-Prot

O08680

Conserved Domains (6) summary

cd09544
Location:840 → 902

SAM_EPH-A3; SAM domain of EPH-A3 subfamily of tyrosine kinase receptors

cd00063
Location:364 → 455

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05066
Location:544 → 810

PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors

pfam00041
Location:254 → 344

fn3; Fibronectin type III domain

pfam14575
Location:492 → 546

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

cl02704
Location:1 → 128

EphR_LBD; Ligand Binding Domain of Ephrin Receptors