Slc16a3 solute carrier family 16 member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc16a3provided by RGD
Official Full Name: solute carrier family 16 member 3provided by RGD
Primary source: RGD:620603
See related: EnsemblRapid:ENSRNOG00000036677 AllianceGenome:RGD:620603
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MCT4; Mct3
Summary: Enables lactate:proton symporter activity. Involved in plasma membrane lactate transport. Located in plasma membrane. Orthologous to human SLC16A3 (solute carrier family 16 member 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 274.7) and Lung (RPKM 15.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.3

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (106712328..106756168)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (106212679..106222564)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (110138519..110148360)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The effects of different training modalities on monocarboxylate transporters MCT1 and MCT4, hypoxia inducible factor-1alpha (HIF-1alpha), and PGC-1alpha gene expression in rat skeletal muscles.
Title: The effects of different training modalities on monocarboxylate transporters MCT1 and MCT4, hypoxia inducible factor-1α (HIF-1α), and PGC-1α gene expression in rat skeletal muscles.
Inhibition of Hypothalamic MCT4 and MCT1-MCT4 Expressions Affects Food Intake and Alters Orexigenic and Anorexigenic Neuropeptide Expressions.
Title: Inhibition of Hypothalamic MCT4 and MCT1-MCT4 Expressions Affects Food Intake and Alters Orexigenic and Anorexigenic Neuropeptide Expressions.
The MCT4 membrane expression varied with estrous cycle stage with expression significantly lower than males. MCT4 membrane expression in OVX females was also lower than males, suggesting that androgens play a role in membrane expression of MCT4.
Title: Sex Hormones Regulate Rat Hepatic Monocarboxylate Transporter Expression and Membrane Trafficking.
Decreased expression of MCT1/4 in distal airway epithelium may disrupt lung branching morphogenesis and thus contribute to the development of pulmonary hypoplasia in the nitrofen-induced congenital diaphragmatic hernia model.
Title: Decreased expression of monocarboxylate transporter 1 and 4 in the branching airway epithelium of nitrofen-induced congenital diaphragmatic hernia.
MPC inhibition is the most sensitive anti-tumour target for LND, with additional inhibitory effects on MCT-mediated L-lactic acid efflux and glutamine/glutamate oxidation.
Title: The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters.
resistance to oxygen- and glucose-deprivation injury in astrocyte-neuron co-cultures occurs via an MCT-dependent mechanism.
Title: Monocarboxylate transporter-dependent mechanism confers resistance to oxygen- and glucose-deprivation injury in astrocyte-neuron co-cultures.
Decreased astroglial monocarboxylate transporter 4 expression in temporal lobe epilepsy
Title: Decreased astroglial monocarboxylate transporter 4 expression in temporal lobe epilepsy.
hypoxia/ischemia induced an upregulation of monocarboxylate transporter 4 expression
Title: Intermittent hypoxia preconditioning-induced epileptic tolerance by upregulation of monocarboxylate transporter 4 expression in rat hippocampal astrocytes.
MCT4 increased 5-10 h postexercise in the hypothalamus only.
Title: Acute exercise increases brain region-specific expression of MCT1, MCT2, MCT4, GLUT1, and COX IV proteins.
Results suggest that acute exercise-induced increases in MCT1 and MCT4 mRNA expression may be possibly mediated by AMPK activation, at least in part in fast-twitch muscle.
Title: Possible involvement of AMPK in acute exercise-induced expression of monocarboxylate transporters MCT1 and MCT4 mRNA in fast-twitch skeletal muscle.

Submit: New GeneRIF Correction See all GeneRIFs (17)

General gene information

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Markers

UniSTS:461931 (e-PCR)
- UniSTS:461931

Slc16a3 (e-PCR), detects polymorphism
- UniSTS:461931

UniSTS:461932 (e-PCR)
- UniSTS:461932

Slc16a3 (e-PCR), detects polymorphism
- UniSTS:461932

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables lactate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables lactate:proton symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables lactate:proton symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables lactate:proton symporter activity	IEA Inferred from Electronic Annotation more info
enables lactate:proton symporter activity	ISO Inferred from Sequence Orthology more info
enables pyruvate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables pyruvate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables pyruvate transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in lactate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in lactate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in plasma membrane lactate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in pyruvate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in pyruvate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in pyruvate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in pyruvate transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in lateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: monocarboxylate transporter 4

Names: MCT 3; MCT 4; monocarboxylate transporter 3; solute carrier family 16 (monocarboxylate transporter), member 3; solute carrier family 16 (monocarboxylic acid transporters), member 3; solute carrier family 16, member 3 (monocarboxylic acid transporter 4)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030834.1 → NP_110461.1 monocarboxylate transporter 4

See identical proteins and their annotated locations for NP_110461.1

Status: PROVISIONAL

Source sequence(s)

U87627

UniProtKB/Swiss-Prot

O35910

UniProtKB/TrEMBL

B4F761

Related

ENSRNOP00000051822.3, ENSRNOT00000054939.5

Conserved Domains (1) summary

cd17430
Location:21 → 410

MFS_MCT3_4; Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

106712328..106756168

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063269935.1 → XP_063126005.1 monocarboxylate transporter 4 isoform X1

UniProtKB/Swiss-Prot

O35910

UniProtKB/TrEMBL

B4F761
XM_063269934.1 → XP_063126004.1 monocarboxylate transporter 4 isoform X1

UniProtKB/Swiss-Prot

O35910

UniProtKB/TrEMBL

B4F761