Eif2b4 eukaryotic translation initiation factor 2B subunit delta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Eif2b4provided by RGD
Official Full Name: eukaryotic translation initiation factor 2B subunit deltaprovided by RGD
Primary source: RGD:620208
See related: EnsemblRapid:ENSRNOG00000005301 AllianceGenome:RGD:620208
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Eif2b
Summary: Enables translation initiation factor binding activity. Contributes to guanyl-nucleotide exchange factor activity. Involved in several processes, including hippocampus development; negative regulation of guanyl-nucleotide exchange factor activity; and response to glucose. Part of eukaryotic translation initiation factor 2B complex. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter 4. Orthologous to human EIF2B4 (eukaryotic translation initiation factor 2B subunit delta). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 207.1), Heart (RPKM 166.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q14

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (30903148..30908803)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (25183177..25188832)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (26546917..26552474)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The eukaryotic initiation factor 2B beta, gamma, delta and epsilon subunit protein levels are maximal at embryonic day 18 and then decrease during development. Aged hippocampus contain only trace amounts of these subunits.
Title: Developmental changes of eukaryotic initiation factor 2B subunits in rat hippocampus.
Significant increases in the relative abundance of the mRNAs coding for the epsilon (33%) and gamma (26%) subunits of eukaryotic initiation factor (eIF) 2B were observed 48 h after the exercise bout.
Title: Alterations in the expression of mRNAs and proteins that code for species relevant to eIF2B activity after an acute bout of resistance exercise.
insulin-like growth factor 1-induced eIF2B activation in neurons is effected by protein phosphatase 1, the activation of which is mediated by the MEK/MAPK signaling pathway
Title: Initiation factor 2B activity is regulated by protein phosphatase 1, which is activated by the mitogen-activated protein kinase-dependent pathway in insulin-like growth factor 1-stimulated neuronal cells.

Submit: New GeneRIF Correction

General gene information

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Markers

AA851483 (e-PCR)
- UniSTS:250471

RH134747 (e-PCR)
- UniSTS:218025

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
contributes_to guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
contributes_to guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info
contributes_to translation initiation factor activity	ISO Inferred from Sequence Orthology more info
contributes_to translation initiation factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables translation initiation factor activity	NAS Non-traceable Author Statement more info	PubMed
enables translation initiation factor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in T cell receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in cytoplasmic translational initiation	IEA Inferred from Electronic Annotation more info
involved_in cytoplasmic translational initiation	ISO Inferred from Sequence Orthology more info
involved_in cytoplasmic translational initiation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in hippocampus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in myelination	IEA Inferred from Electronic Annotation more info
involved_in myelination	ISO Inferred from Sequence Orthology more info
involved_in myelination	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in oligodendrocyte development	IEA Inferred from Electronic Annotation more info
involved_in oligodendrocyte development	ISO Inferred from Sequence Orthology more info
involved_in oligodendrocyte development	ISS Inferred from Sequence or Structural Similarity more info
involved_in ovarian follicle development	IEA Inferred from Electronic Annotation more info
involved_in ovarian follicle development	ISO Inferred from Sequence Orthology more info
involved_in ovarian follicle development	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to glucose	IDA Inferred from Direct Assay more info	PubMed
involved_in response to heat	IDA Inferred from Direct Assay more info	PubMed
involved_in response to peptide hormone	IDA Inferred from Direct Assay more info	PubMed
involved_in translational initiation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	ISO Inferred from Sequence Orthology more info
involved_in translational initiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in translational initiation	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 2B complex	IDA Inferred from Direct Assay more info	PubMed
part_of eukaryotic translation initiation factor 2B complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 2B complex	ISO Inferred from Sequence Orthology more info
part_of eukaryotic translation initiation factor 2B complex	ISS Inferred from Sequence or Structural Similarity more info
part_of eukaryotic translation initiation factor 2B complex	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: translation initiation factor eIF2B subunit delta

Names: eIF-2B GDP-GTP exchange factor subunit delta; eIF2B GDP-GTP exchange factor subunit delta; eukaryotic translation initiation factor 2B subunit 4; eukaryotic translation initiation factor 2B, subunit 4 delta; translation initiation factor eIF-2B subunit delta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053950.1 → NP_446402.1 translation initiation factor eIF2B subunit delta

See identical proteins and their annotated locations for NP_446402.1

Status: PROVISIONAL

Source sequence(s)

Z48225

UniProtKB/Swiss-Prot

Q63186

UniProtKB/TrEMBL

A0A096MIS3, A6HA70

Related

ENSRNOP00000092958.1, ENSRNOT00000110149.2

Conserved Domains (1) summary

pfam01008
Location:220 → 510

IF-2B; Initiation factor 2 subunit family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

30903148..30908803

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039111697.1 → XP_038967625.1 translation initiation factor eIF2B subunit delta isoform X1

UniProtKB/TrEMBL

A0A096MIS3

Related

ENSRNOP00000007763.6, ENSRNOT00000007763.7

Conserved Domains (1) summary

pfam01008
Location:240 → 530

IF-2B; Initiation factor 2 subunit family