Rps6ka2 ribosomal protein S6 kinase, polypeptide 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rps6ka2provided by MGI
Official Full Name: ribosomal protein S6 kinase, polypeptide 2provided by MGI
Primary source: MGI:MGI:1342290
See related: Ensembl:ENSMUSG00000023809 AllianceGenome:MGI:1342290
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rsk3; 90kDa; p90rsk; pp90rsk; D17Wsu134e; Rps6ka-rs1
Summary: Enables ribosomal protein S6 kinase activity. Acts upstream of or within several processes, including cardiac muscle cell apoptotic process; oocyte maturation; and regulation of gene expression. Located in cytoplasm and meiotic spindle. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Orthologous to human RPS6KA2 (ribosomal protein S6 kinase A2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 18.1), heart adult (RPKM 11.1) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A1; 17 4.7 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (7356384..7570714)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (7088971..7303315)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rps6ka2 enhances iMSC chondrogenic differentiation to attenuate knee osteoarthritis through articular cartilage regeneration in mice.
Title: Rps6ka2 enhances iMSC chondrogenic differentiation to attenuate knee osteoarthritis through articular cartilage regeneration in mice.
Dual targeting of brain region-specific kinases potentiates neurological rescue in Spinocerebellar ataxia type 1.
Title: Dual targeting of brain region-specific kinases potentiates neurological rescue in Spinocerebellar ataxia type 1.
RSK3 mediates necroptosis by regulating phosphorylation of RIP3 in rat retinal ganglion cells.
Title: RSK3 mediates necroptosis by regulating phosphorylation of RIP3 in rat retinal ganglion cells.
A Non-canonical PDK1-RSK Signal Diminishes Pro-caspase-8-Mediated Necroptosis Blockade.
Title: A Non-canonical PDK1-RSK Signal Diminishes Pro-caspase-8-Mediated Necroptosis Blockade.
We confirmed that Raf1(L613V) knock-in confers a NS-like phenotype, including cardiac hypertrophy. Active RSK3 was increased in Raf1(L613V) mice. Constitutive RSK3 gene deletion prevented the Raf1(L613V)-dependent concentric growth in width of the cardiac myocyte and attenuated cardiac hypertrophy in female mice.
Title: RSK3 is required for concentric myocyte hypertrophy in an activated Raf1 model for Noonan syndrome.
RSK3 is required for the induction of interstitial cardiac fibrosis in alpha-tropomyosin Glu180Gly transgenic mice.
Title: p90 ribosomal S6 kinase 3 contributes to cardiac insufficiency in α-tropomyosin Glu180Gly transgenic mice.
Anchored RSK3 transduces signals that modulate pathologic myocyte growth in cardiac hypertrophy.
Title: Anchored p90 ribosomal S6 kinase 3 is required for cardiac myocyte hypertrophy.
p90RSK2 is dispensable for BCR-Abl-induced myeloid leukemia, but may be required for pathogenesis and lineage determination in Flt3-internal tandem duplication-induced hematopoietic transformation.
Title: p90RSK2 is essential for FLT3-ITD- but dispensable for BCR-ABL-induced myeloid leukemia.
These data indicate that Ribosomal s6 kinase 2 negatively regulates axon elongation via the MAPK pathway.
Title: P90 Ribosomal s6 kinase 2 negatively regulates axon growth in motoneurons.
RSK2 is a key regulator for cell transformation induced by tumor promoters such as EGF and TPA.
Title: Ribosomal S6 kinase 2 is a key regulator in tumor promoter induced cell transformation.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Rps6ka2 (e-PCR), detects polymorphism
- UniSTS:469821

Rps6ka2 (e-PCR), detects polymorphism
- UniSTS:507200

RH125854 (e-PCR)
- UniSTS:142169

D17Jcs90 (e-PCR), detects polymorphism
- UniSTS:259311

NoName (e-PCR)
- UniSTS:237567

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info
enables protein serine/threonine/tyrosine kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables ribosomal protein S6 kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribosomal protein S6 kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within brain renin-angiotensin system	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cardiac muscle cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to carbohydrate stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart contraction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within heart development	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of meiotic nuclear division	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within oocyte maturation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of protein processing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in meiotic spindle	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ribosomal protein S6 kinase alpha-2

Names: 90 kDa ribosomal protein S6 kinase 2; MAP kinase-activated protein kinase 1c; MAPK-activated protein kinase 1c; MAPKAP kinase 1c; MAPKAPK-1c; RSK-3; S6K-alpha 2; p90-RSK 2; p90RSK2; pp90RSK3; protein-tyrosine kinase Mpk-9; ribosomal S6 kinase 3; ribosomal protein S6 kinase, 90kD, polypeptide 2

NP_035429.1

EC 2.7.11.1

XP_006523261.1

EC 2.7.11.1

XP_006523262.1

EC 2.7.11.1

XP_006523263.1

EC 2.7.11.1

XP_006523264.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011299.5 → NP_035429.1 ribosomal protein S6 kinase alpha-2

See identical proteins and their annotated locations for NP_035429.1

Status: VALIDATED

Source sequence(s)

AC117241, AC126433

Consensus CDS

CCDS28376.1

UniProtKB/Swiss-Prot

Q9D2C0, Q9WUT3

UniProtKB/TrEMBL

Q7TPD5

Related

ENSMUSP00000024575.7, ENSMUST00000024575.8

Conserved Domains (2) summary

cd05582
Location:63 → 379

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14178
Location:411 → 703

STKc_RSK3_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called Ribosomal protein S6 kinase alpha-2 or 90kDa ribosomal protein S6 kinase 2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

7356384..7570714

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006523199.4 → XP_006523262.1 ribosomal protein S6 kinase alpha-2 isoform X2

UniProtKB/TrEMBL

Q8CHM5

Conserved Domains (2) summary

cd05582
Location:46 → 362

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14178
Location:394 → 686

STKc_RSK3_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called Ribosomal protein S6 kinase alpha-2 or 90kDa ribosomal protein S6 kinase 2)
XM_006523198.5 → XP_006523261.1 ribosomal protein S6 kinase alpha-2 isoform X1

UniProtKB/TrEMBL

A0AAQ4VMS3, Q8CHM5

Related

ENSMUSP00000159974.1, ENSMUST00000249877.1

Conserved Domains (2) summary

cd05582
Location:47 → 363

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14178
Location:395 → 687

STKc_RSK3_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called Ribosomal protein S6 kinase alpha-2 or 90kDa ribosomal protein S6 kinase 2)
XM_006523201.2 → XP_006523264.1 ribosomal protein S6 kinase alpha-2 isoform X3

See identical proteins and their annotated locations for XP_006523264.1

UniProtKB/TrEMBL

Q8CHM5

Conserved Domains (2) summary

cd14178
Location:304 → 596

STKc_RSK3_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called Ribosomal protein S6 kinase alpha-2 or 90kDa ribosomal protein S6 kinase 2)

cl21453
Location:1 → 272

PKc_like; Protein Kinases, catalytic domain
XM_006523200.2 → XP_006523263.1 ribosomal protein S6 kinase alpha-2 isoform X3

See identical proteins and their annotated locations for XP_006523263.1

UniProtKB/TrEMBL

Q8CHM5

Conserved Domains (2) summary

cd14178
Location:304 → 596

STKc_RSK3_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called Ribosomal protein S6 kinase alpha-2 or 90kDa ribosomal protein S6 kinase 2)

cl21453
Location:1 → 272

PKc_like; Protein Kinases, catalytic domain