TRX2 thioredoxin TRX2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: TRX2
Official Full Name: thioredoxin TRX2
Primary source: SGD:S000003441
Locus tag: YGR209C
See related: AllianceGenome:SGD:S000003441; FungiDB:YGR209C; VEuPathDB:YGR209C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: LMA1
Summary: Predicted to enable disulfide oxidoreductase activity. Involved in several processes, including Golgi vesicle transport; cell redox homeostasis; and vacuole organization. Located in cytosol. Orthologous to human TXN (thioredoxin). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See TRX2 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (912913..913227, complement)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Broader than expected tolerance for substitutions in the WCGPCK catalytic motif of yeast thioredoxin 2.
Title: Broader than expected tolerance for substitutions in the WCGPCK catalytic motif of yeast thioredoxin 2.
In fibroblasts from TRX2 deficiency patient, an important role for reactive oxygen species was found for neuronal maintenance.
Title: Human thioredoxin 2 deficiency impairs mitochondrial redox homeostasis and causes early-onset neurodegeneration.
Trx2p is a new positive effector in the regulation of the Skn7p transcription factor that controls phosphorylation events and, modulates the oxidative stress response in yeast.
Title: Trx2p-dependent regulation of Saccharomyces cerevisiae oxidative stress response by the Skn7p transcription factor under respiring conditions.
Trx2 is required for maintaining the redox status in Saccharomyces cerevisiae under conditions of physiological stress.
Title: A fluorescence resonance energy transfer (FRET)-based redox sensor reveals physiological role of thioredoxin in the yeast Saccharomyces cerevisiae.
TRX2 is required to maintain the IMS small Tim proteins in reduced forms and facilitate their mitochondrial import
Title: Cytosolic thioredoxin system facilitates the import of mitochondrial small Tim proteins.
Overexpression of TRX2 gene reduced oxidative cellular damage.
Title: Reduction of oxidative cellular damage by overexpression of the thioredoxin TRX2 gene improves yield and quality of wine yeast dry active biomass.
Trx1 and Trx2 are essential for the nuclear accumulation of Msn2/4 and Maf1.
Title: H2O2 activates the nuclear localization of Msn2 and Maf1 through thioredoxins in Saccharomyces cerevisiae.
Human wt p53 expression in yeast leads to gene repression of thioredoxin (TRX1/2), a highly conserved multifunctional antioxidative and antiapoptotic protein family.
Title: Human p53 induces cell death and downregulates thioredoxin expression in Saccharomyces cerevisiae.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables disulfide oxidoreductase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein-disulfide reductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell redox homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in deoxyribonucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IDA Inferred from Direct Assay more info	PubMed
involved_in glutathione metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein deglutathionylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein deglutathionylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein deglutathionylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
involved_in sulfate assimilation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vacuole fusion, non-autophagic	IDA Inferred from Direct Assay more info	PubMed
involved_in vacuole inheritance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: thioredoxin TRX2

NP_011725.3

Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system that protects cells from oxidative and reductive stress; subunit of the LMA1 complex, with Pbi2p, that promotes vacuole inheritance; cofactor for Tsa1p; required for ER-Golgi transport; facilitates mitochondrial import of small Tims (Tim9p, Tim10p, Tim13p) by maintaining them in reduced form along with Trx1p; component of a signal transduction redox relay in a light sensing pathway; abundance increases under DNA replication stress