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    VPS38 Vps38p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851074, updated on 9-Dec-2024

    Summary

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    Official Symbol
    VPS38
    Official Full Name
    Vps38p
    Primary source
    SGD:S000004352
    Locus tag
    YLR360W
    See related
    AllianceGenome:SGD:S000004352; FungiDB:YLR360W; VEuPathDB:YLR360W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    VPL17
    Summary
    Predicted to enable SNARE binding activity. Involved in cellular response to potassium ion starvation; late endosome to vacuole transport; and macroautophagy. Located in fungal-type vacuole membrane. Part of phosphatidylinositol 3-kinase complex, class III, type II. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See VPS38 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (846103..847422)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Rsc2p Neighboring gene uncharacterized protein Neighboring gene adenylosuccinase ADE13 Neighboring gene phosphoprotein phosphatase Neighboring gene uncharacterized protein Neighboring gene mitogen-activated protein kinase kinase kinase STE11

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The PI3 Kinase Complex II-PI3P-Vps27 Axis on Vacuolar Membranes is Critical for Microautophagy Induction and Nutrient Stress Adaptation. Tasnin MN, et al. J Mol Biol, 2022 Jan 30. PMID 34798133
    2. Structure of the novel C-terminal domain of vacuolar protein sorting 30/autophagy-related protein 6 and its specific role in autophagy. Noda NN, et al. J Biol Chem, 2012 May 11. PMID 22437838, Free PMC Article
    3. Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes. Rostislavleva K, et al. Science, 2015 Oct 9. PMID 26450213, Free PMC Article
    4. Autophagosome formation can be achieved in the absence of Atg18 by expressing engineered PAS-targeted Atg2. Kobayashi T, et al. FEBS Lett, 2012 Jul 30. PMID 22728243
    5. Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. Kihara A, et al. J Cell Biol, 2001 Feb 5. PMID 11157979, Free PMC Article

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in SNARE complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to potassium ion starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in late endosome to vacuole transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole membrane HDA PubMed 
    is_active_in lytic vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of phosphatidylinositol 3-kinase complex, class III, type II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of phosphatidylinositol 3-kinase complex, class III, type II IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Vps38p
    NP_013464.3
    • Part of a Vps34p phosphatidylinositol 3-kinase complex; functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity; required for overflow degradation of misfolded proteins when ERAD is saturated; targeted to vacuole via AP-3 pathway

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      846103..847422
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182249.3 → NP_013464.3  TPA: Vps38p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013464.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYZ7, Q05919, Q6B1J7
      UniProtKB/TrEMBL
      B3RHM8, B5VNQ1, C7GRY4, C8ZDW7
      Conserved Domains (1) summary
      pfam17649
      Location:1 → 436
      VPS38; Vacuolar protein sorting 38
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05919.1

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