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    LIP1 sphingosine N-acyltransferase subunit LIP1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855344, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LIP1
    Official Full Name
    sphingosine N-acyltransferase subunit LIP1
    Primary source
    SGD:S000004913
    Locus tag
    YMR298W
    See related
    AllianceGenome:SGD:S000004913; FungiDB:YMR298W; VEuPathDB:YMR298W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to sphingosine N-acyltransferase activity. Involved in ceramide biosynthetic process. Located in endoplasmic reticulum membrane. Part of acyl-CoA ceramide synthase complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See LIP1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (863819..864271)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene serine C-palmitoyltransferase LCB1 Neighboring gene carboxypeptidase C PRC1 Neighboring gene dynein light intermediate chain Neighboring gene amidophosphoribosyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure and mechanism of a eukaryotic ceramide synthase complex. Xie T, et al. EMBO J, 2023 Dec 11. PMID 37953642, Free PMC Article
    2. Lip1p: a novel subunit of acyl-CoA ceramide synthase. Vallée B, et al. EMBO J, 2005 Feb 23. PMID 15692566, Free PMC Article
    3. Defect of synthesis of very long-chain fatty acids confers resistance to growth inhibition by inositol phosphorylceramide synthase repression in yeast Saccharomyces cerevisiae. Tani M, et al. J Biochem, 2010 Nov. PMID 20709688
    4. Hydroxylation state of fatty acid and long-chain base moieties of sphingolipid determine the sensitivity to growth inhibition due to AUR1 repression in Saccharomyces cerevisiae. Tani M, et al. Biochem Biophys Res Commun, 2012 Jan 13. PMID 22166213
    5. Regulation of sphingolipid biosynthesis in the endoplasmic reticulum via signals from the plasma membrane in budding yeast. Ishino Y, et al. FEBS J, 2022 Jan. PMID 34492164

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulation of sphingolipid biosynthesis in the endoplasmic reticulum via signals from the plasma membrane in budding yeast.
      Title: Regulation of sphingolipid biosynthesis in the endoplasmic reticulum via signals from the plasma membrane in budding yeast.
    2. Lip1 is a single-span endoplasmic reticulum membrane protein that is required for ceramide synthesis in vivo and in vitro. [Lip1]
      Title: Lip1p: a novel subunit of acyl-CoA ceramide synthase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to sphingosine N-acyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ceramide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ceramide biosynthetic process IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of acyl-CoA ceramide synthase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope HDA PubMed 

    General protein information

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    Preferred Names
    sphingosine N-acyltransferase subunit LIP1
    NP_014027.1
    • Ceramide synthase subunit; single-span ER membrane protein associated with Lag1p and Lac1p and required for ceramide synthase activity, null mutant grows extremely slowly and is defective in ceramide synthesis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      863819..864271
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182807.1 → NP_014027.1  TPA: sphingosine N-acyltransferase subunit LIP1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014027.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZN14, D6W0C5, Q03579
      UniProtKB/TrEMBL
      B3LMI6, C7GTK1, C8ZFG7, G2WL07, N1NYV7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03579.1

    Gene LinkOut

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