GTT1 bifunctional glutathione transferase/peroxidase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: GTT1
Official Full Name: bifunctional glutathione transferase/peroxidase
Primary source: SGD:S000001477
Locus tag: YIR038C
See related: AllianceGenome:SGD:S000001477; FungiDB:YIR038C; VEuPathDB:YIR038C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables glutathione peroxidase activity and glutathione transferase activity. Involved in glutathione metabolic process and protein glutathionylation. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See GTT1 in Genome Data Viewer

Location:: chromosome: IX

Exon count:: 1

Sequence:: Chromosome: IX; NC_001141.2 (423809..424513, complement)

Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glutathione transferases, Gtt1 and Gtt2, seem to be crucial in the response to H2O2 stress.
Title: Involvement of glutathione transferases, Gtt1and Gtt2, with oxidative stress response generated by H2O2 during growth of Saccharomyces cerevisiae.
Gtt1 and Gtt2 play different roles in the mechanism of cadmium detoxification.
Title: The role of glutathione transferases in cadmium stress.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables glutathione peroxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione transferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in glutathione metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein glutathionylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell periphery	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	HDA more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed

General protein information

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Preferred Names: bifunctional glutathione transferase/peroxidase

NP_012304.1

EC 2.5.1.18

ER associated glutathione S-transferase; capable of homodimerization; glutathione transferase for Yvc1p vacuolar cation channel; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001141.2 Reference assembly

Range

423809..424513 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179560.1 → NP_012304.1 TPA: bifunctional glutathione transferase/peroxidase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012304.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VVW9, P40582

UniProtKB/TrEMBL

A6ZVV8, B3LTH2, C7GLR8, C8ZAU1, G2WFW6, N1P0S6

Conserved Domains (2) summary

cd03189
Location:93 → 218

GST_C_GTT1_like; C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases

cd03046
Location:6 → 87

GST_N_GTT1_like; GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved ...