Zyx zyxin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zyxprovided by MGI
Official Full Name: zyxinprovided by MGI
Primary source: MGI:MGI:103072
See related: Ensembl:ENSMUSG00000029860 AllianceGenome:MGI:103072
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 9530098H06Rik
Summary: Predicted to enable metal ion binding activity. Involved in cell-matrix adhesion; integrin-mediated signaling pathway; and transforming growth factor beta receptor signaling pathway. Acts upstream of or within cellular response to type II interferon. Located in focal adhesion and phagocytic vesicle. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; gut; and heart. Orthologous to human ZYX (zyxin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in lung adult (RPKM 88.7), ovary adult (RPKM 71.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B2.1; 6 20.64 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (42326507..42337158)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (42349511..42360213)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zyxin is important for the stability and function of podocytes, especially during mechanical stretch.
Title: Zyxin is important for the stability and function of podocytes, especially during mechanical stretch.
Zyxin regulates embryonic stem cell fate by modulating mechanical and biochemical signaling interface.
Title: Zyxin regulates embryonic stem cell fate by modulating mechanical and biochemical signaling interface.
Zyxin protects from hypertension-induced cardiac dysfunction.
Title: Zyxin protects from hypertension-induced cardiac dysfunction.
Essential role of zyxin in platelet biogenesis and glycoprotein Ib-IX surface expression.
Title: Essential role of zyxin in platelet biogenesis and glycoprotein Ib-IX surface expression.
Study findings identify zyxin as a physiological regulator of endothelial exocytosis through reorganizing local actin network in the final stage of exocytosis. Zyxin-deficient mice exhibit impaired epinephrine-stimulated VWF release, prolonged bleeding time and thrombosis, largely due to defective endothelial secretion of VWF.
Title: Zyxin regulates endothelial von Willebrand factor secretion by reorganizing actin filaments around exocytic granules.
these observations suggest that Zyxin promotes colon cancer tumorigenesis in a mitotic-phosphorylation-dependent manner and through CDK8-mediated YAP activation.
Title: Zyxin promotes colon cancer tumorigenesis in a mitotic phosphorylation-dependent manner and through CDK8-mediated YAP activation.
zyxin influences focal adhesion dynamics, that it recruits Tes and that this interaction is functional in regulating cell spreading.
Title: Delineating the Tes Interaction Site in Zyxin and Studying Cellular Effects of Its Disruption.
Zyxin contributes to the migratory and invasive phenotype evoked by Tead2.
Title: Tead2 expression levels control the subcellular distribution of Yap and Taz, zyxin expression and epithelial-mesenchymal transition.
Integrin-beta5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor beta.
Title: Integrin-β5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor β.
paxillin and zyxin are LIM-domain adaptor proteins that are recruited to stress fiber strain sites
Title: LIM domains target actin regulators paxillin and zyxin to sites of stress fiber strain.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124207 (e-PCR)
- UniSTS:161029

D4Got51 (e-PCR)
- UniSTS:115356

Zyx (e-PCR), detects polymorphism
- UniSTS:508572

RH125177 (e-PCR)
- UniSTS:161999

NoName (e-PCR)
- UniSTS:224737

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in stress fiber assembly	IEA Inferred from Electronic Annotation more info
involved_in stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in stress fiber	IBA Inferred from Biological aspect of Ancestor more info
located_in stress fiber	IEA Inferred from Electronic Annotation more info
located_in stress fiber	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zyxin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289617.2 → NP_001276546.1 zyxin isoform a

See identical proteins and their annotated locations for NP_001276546.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (a).

Source sequence(s)

AC153915

Consensus CDS

CCDS20066.1

UniProtKB/Swiss-Prot

P70461, Q3UGQ3, Q62523

UniProtKB/TrEMBL

Q3TCR9

Related

ENSMUSP00000126622.2, ENSMUST00000164375.4

Conserved Domains (4) summary

cd09353
Location:436 → 495

LIM2_Zyxin; The second LIM domain of Zyxin

cd09435
Location:496 → 562

LIM3_Zyxin; The third LIM domain of Zyxin

PHA03247
Location:175 → 368

PHA03247; large tegument protein UL36; Provisional

cl02475
Location:343 → 429

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001289618.2 → NP_001276547.1 zyxin isoform b

See identical proteins and their annotated locations for NP_001276547.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks an alternate in-frame exon and differs in the 3' UTR, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 3 and 4 encode the same isoform (b).

Source sequence(s)

AC153915

Consensus CDS

CCDS85034.1

UniProtKB/TrEMBL

Q3TCR9, Q7TQE2

Related

ENSMUSP00000145236.2, ENSMUST00000203401.3

Conserved Domains (4) summary

cd09353
Location:405 → 464

LIM2_Zyxin; The second LIM domain of Zyxin

cd09435
Location:465 → 531

LIM3_Zyxin; The third LIM domain of Zyxin

PHA03247
Location:5 → 311

PHA03247; large tegument protein UL36; Provisional

cl02475
Location:312 → 398

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001289619.2 → NP_001276548.1 zyxin isoform b

See identical proteins and their annotated locations for NP_001276548.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 3 and 4 encode the same isoform (b).

Source sequence(s)

AC153915

Consensus CDS

CCDS85034.1

UniProtKB/TrEMBL

Q3TCR9, Q7TQE2

Related

ENSMUSP00000070427.8, ENSMUST00000070635.13

Conserved Domains (4) summary

cd09353
Location:405 → 464

LIM2_Zyxin; The second LIM domain of Zyxin

cd09435
Location:465 → 531

LIM3_Zyxin; The third LIM domain of Zyxin

PHA03247
Location:5 → 311

PHA03247; large tegument protein UL36; Provisional

cl02475
Location:312 → 398

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001415802.1 → NP_001402731.1 zyxin isoform a

Status: VALIDATED

Source sequence(s)

AC153915

UniProtKB/Swiss-Prot

P70461, Q3UGQ3, Q62523
NM_011777.4 → NP_035907.1 zyxin isoform a

See identical proteins and their annotated locations for NP_035907.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1 and 2 encode the same isoform (a).

Source sequence(s)

AC153915

Consensus CDS

CCDS20066.1

UniProtKB/Swiss-Prot

P70461, Q3UGQ3, Q62523

UniProtKB/TrEMBL

Q3TCR9

Related

ENSMUSP00000145451.2, ENSMUST00000203652.3

Conserved Domains (4) summary

cd09353
Location:436 → 495

LIM2_Zyxin; The second LIM domain of Zyxin

cd09435
Location:496 → 562

LIM3_Zyxin; The third LIM domain of Zyxin

PHA03247
Location:175 → 368

PHA03247; large tegument protein UL36; Provisional

cl02475
Location:343 → 429

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

42326507..42337158

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030255327.2 → XP_030111187.1 zyxin isoform X2

UniProtKB/TrEMBL

Q3TCR9, Q7TQE2

Conserved Domains (4) summary

cd09353
Location:405 → 464

LIM2_Zyxin; The second LIM domain of Zyxin

cd09435
Location:465 → 531

LIM3_Zyxin; The third LIM domain of Zyxin

PHA03247
Location:5 → 311

PHA03247; large tegument protein UL36; Provisional

cl02475
Location:312 → 398

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
XM_036166031.1 → XP_036021924.1 zyxin isoform X2

UniProtKB/TrEMBL

Q3TCR9, Q7TQE2

Conserved Domains (4) summary

cd09353
Location:405 → 464

LIM2_Zyxin; The second LIM domain of Zyxin

cd09435
Location:465 → 531

LIM3_Zyxin; The third LIM domain of Zyxin

PHA03247
Location:5 → 311

PHA03247; large tegument protein UL36; Provisional

cl02475
Location:312 → 398

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
XM_036166032.1 → XP_036021925.1 zyxin isoform X3

UniProtKB/TrEMBL

Q8CD55

Conserved Domains (4) summary

cd09353
Location:337 → 396

LIM2_Zyxin; The second LIM domain of Zyxin

cd09435
Location:397 → 463

LIM3_Zyxin; The third LIM domain of Zyxin

PHA03247
Location:76 → 269

PHA03247; large tegument protein UL36; Provisional

cl02475
Location:244 → 330

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers