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    Atp4b ATPase, H+/K+ exchanging, beta polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 11945, updated on 9-Dec-2024

    Summary

    Official Symbol
    Atp4bprovided by MGI
    Official Full Name
    ATPase, H+/K+ exchanging, beta polypeptideprovided by MGI
    Primary source
    MGI:MGI:88114
    See related
    Ensembl:ENSMUSG00000031449 AllianceGenome:MGI:88114
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable ATPase activator activity and P-type potassium:proton transporter activity. Predicted to contribute to heterocyclic compound binding activity. Predicted to be involved in intracellular monoatomic cation homeostasis; monoatomic cation transmembrane transport; and pH reduction. Predicted to act upstream of or within protein glycosylation and regulation of proton transport. Predicted to be located in endoplasmic reticulum and plasma membrane. Predicted to be part of potassium:proton exchanging ATPase complex and sodium:potassium-exchanging ATPase complex. Is expressed in alimentary system; stomach; stomach epithelium; stomach fundus; and stomach mucosa. Human ortholog(s) of this gene implicated in atrophic gastritis; autoimmune gastritis; and stomach cancer. Orthologous to human ATP4B (ATPase H+/K+ transporting subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward stomach adult (RPKM 1152.3) See more
    Orthologs
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    Genomic context

    See Atp4b in Genome Data Viewer
    Location:
    8 A1.1; 8 5.89 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (13436209..13446778, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (13386209..13396778, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene defective in cullin neddylation 1 domain containing 2 Neighboring gene predicted gene, 25014 Neighboring gene transmembrane and coiled-coil domains 3 Neighboring gene STARR-positive B cell enhancer ABC_E6621 Neighboring gene transcription factor Dp 1 Neighboring gene G protein-coupled receptor kinase 1 Neighboring gene transmembrane protein 255B Neighboring gene growth arrest specific 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables P-type potassium:proton transporter activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables heterocyclic compound binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to heterocyclic compound binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular potassium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular sodium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within pH reduction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in pH reduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein glycosylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of proton transport ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sodium ion export across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of potassium:proton exchanging ATPase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of sodium:potassium-exchanging ATPase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of sodium:potassium-exchanging ATPase complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    potassium-transporting ATPase subunit beta
    Names
    ATPase, H+/K+ transporting, beta polypeptide, gastric specific
    H+,K+-ATPase
    H+/K+-ATPase beta
    H,K-ATPase-Beta
    gastric H(+)/K(+) ATPase subunit beta
    proton pump beta chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009724.2NP_033854.1  potassium-transporting ATPase subunit beta

      See identical proteins and their annotated locations for NP_033854.1

      Status: VALIDATED

      Source sequence(s)
      AC130818
      Consensus CDS
      CCDS22111.1
      UniProtKB/Swiss-Prot
      P50992, Q9D6S3, Q9D6T2, Q9D6Y2
      UniProtKB/TrEMBL
      Q0VBB6
      Related
      ENSMUSP00000033826.3, ENSMUST00000033826.4
      Conserved Domains (1) summary
      TIGR01107
      Location:2294
      Na_K_ATPase_bet; Sodium Potassium ATPase beta subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      13436209..13446778 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)