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    Pttg1 pituitary tumor-transforming gene 1 [ Mus musculus (house mouse) ]

    Gene ID: 30939, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Pttg1provided by MGI
    Official Full Name
    pituitary tumor-transforming gene 1provided by MGI
    Primary source
    MGI:MGI:1353578
    See related
    Ensembl:ENSMUSG00000020415 AllianceGenome:MGI:1353578
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pttg; Pttg3
    Summary
    Enables cysteine-type endopeptidase inhibitor activity. Acts upstream of or within homologous chromosome segregation; mitotic sister chromatid cohesion; and smoothened signaling pathway. Located in cytoplasm and nucleus. Is active in axoneme. Is expressed in several structures, including central nervous system; eye; limb; mesonephric tubule of male; and testis. Orthologous to several human genes including PTTG1 (PTTG1 regulator of sister chromatid separation, securin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 18.7), testis adult (RPKM 15.6) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pttg1 in Genome Data Viewer
    Location:
    11 B1.1; 11 25.68 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (43311097..43317417, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (43420244..43427463, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene microRNA 146 Neighboring gene STARR-positive B cell enhancer ABC_E9138 Neighboring gene predicted gene 5782 Neighboring gene STARR-positive B cell enhancer ABC_E3940 Neighboring gene STARR-positive B cell enhancer ABC_E6968 Neighboring gene SLU7 splicing factor homolog (S. cerevisiae) Neighboring gene predicted gene 12151

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Pituitary tumor transforming gene-null male mice exhibit impaired pancreatic beta cell proliferation and diabetes. Wang Z, et al. Proc Natl Acad Sci U S A, 2003 Mar 18. PMID 12626748, Free PMC Article
    2. Pituitary senescence: the evolving role of Pttg. Chesnokova V, et al. Mol Cell Endocrinol, 2010 Sep 15. PMID 20153804, Free PMC Article
    3. Securin and not CDK1/cyclin B1 regulates sister chromatid disjunction during meiosis II in mouse eggs. Nabti I, et al. Dev Biol, 2008 Sep 15. PMID 18639540
    4. Characterization of the pituitary tumor transforming gene 1 knockout mouse retina. Yetemian RM, et al. Neurochem Res, 2011 Apr. PMID 21203837, Free PMC Article
    5. Pituitary tumor transforming gene (PTTG) transforming and transactivation activity. Wang Z, et al. J Biol Chem, 2000 Mar 17. PMID 10713046

    See all (99) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MEIKIN expression and its C-terminal phosphorylation by PLK1 is closely related the metaphase-anaphase transition by affecting cyclin B1 and Securin stabilization in meiotic oocyte.
      Title: MEIKIN expression and its C-terminal phosphorylation by PLK1 is closely related the metaphase-anaphase transition by affecting cyclin B1 and Securin stabilization in meiotic oocyte.
    2. PTTG1 Reprograms Asparagine Metabolism to Promote Hepatocellular Carcinoma Progression.
      Title: PTTG1 Reprograms Asparagine Metabolism to Promote Hepatocellular Carcinoma Progression.
    3. PTTG1 alleviates acute alcoholic liver injury by inhibiting endoplasmic reticulum stress-induced hepatocyte pyroptosis.
      Title: PTTG1 alleviates acute alcoholic liver injury by inhibiting endoplasmic reticulum stress-induced hepatocyte pyroptosis.
    4. The pituitary tumour-transforming gene 1/delta-like homologue 1 pathway plays a key role in liver fibrogenesis.
      Title: The pituitary tumour-transforming gene 1/delta-like homologue 1 pathway plays a key role in liver fibrogenesis.
    5. Involvement of histone deacetylase 1/2 in adrenocorticotropic hormone synthesis and proliferation of corticotroph tumor AtT-20 cells.
      Title: Involvement of histone deacetylase 1/2 in adrenocorticotropic hormone synthesis and proliferation of corticotroph tumor AtT-20 cells.
    6. A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes.
      Title: A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes.
    7. The lifespan quantitative trait locus gene Securin controls hematopoietic progenitor cell function.
      Title: The lifespan quantitative trait locus gene Securin controls hematopoietic progenitor cell function.
    8. The findings show that maternal aging compromises the oocyte SAC-APC/C axis leading to a decrease in securin that ultimately causes sister chromatid cohesion loss.
      Title: Maternal age-dependent APC/C-mediated decrease in securin causes premature sister chromatid separation in meiosis II.
    9. Smurf1 interacts with and targets Securin, an inhibitor of sister-chromatid separation, for poly-ubiquitination and proteasomal degradation.
      Title: Smurf1 targets Securin for ubiquitin-dependent degradation and regulates the metaphase-to-anaphase transition.
    10. High PTTG1 expression is associated with pituitary tumor development.
      Title: mTOR promotes pituitary tumor development through activation of PTTG1.
    Submit: New GeneRIF Correction See all GeneRIFs (37)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (8)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heat shock protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular function activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chromosome segregation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in homologous chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within homologous chromosome segregation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within mitotic sister chromatid cohesion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within smoothened signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in axoneme IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    securin
    Names
    pituitary tumor-transforming 1
    pituitary tumor-transforming gene 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001131054.3 → NP_001124526.1  securin isoform 1

      See identical proteins and their annotated locations for NP_001124526.1

      Status: VALIDATED

      Source sequence(s)
      AL670472
      Consensus CDS
      CCDS48771.1
      UniProtKB/Swiss-Prot
      O88887, Q9CQJ7, Q9Z2E6
      UniProtKB/TrEMBL
      Q3Y5K4
      Related
      ENSMUSP00000020687.9, ENSMUST00000020687.15
      Conserved Domains (1) summary
      pfam04856
      Location:1 → 188
      Securin; Securin sister-chromatid separation inhibitor

    2. NM_001362799.2 → NP_001349728.1  securin isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL670472
      Consensus CDS
      CCDS48771.1
      UniProtKB/Swiss-Prot
      O88887, Q9CQJ7, Q9Z2E6
      UniProtKB/TrEMBL
      Q3Y5K4
      Related
      ENSMUSP00000098894.5, ENSMUST00000101340.11
      Conserved Domains (1) summary
      pfam04856
      Location:1 → 188
      Securin; Securin sister-chromatid separation inhibitor

    3. NM_001425538.1 → NP_001412467.1  securin isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL670472
      UniProtKB/Swiss-Prot
      O88887, Q9CQJ7, Q9Z2E6
      Related
      ENSMUSP00000112834.2, ENSMUST00000118368.8

    4. NM_001425539.1 → NP_001412468.1  securin isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL670472
      UniProtKB/Swiss-Prot
      O88887, Q9CQJ7, Q9Z2E6
      Related
      ENSMUSP00000112815.2, ENSMUST00000121638.8

    5. NM_001425540.1 → NP_001412469.1  securin isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL670472
      UniProtKB/Swiss-Prot
      O88887, Q9CQJ7, Q9Z2E6

    6. NM_001425541.1 → NP_001412470.1  securin isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL670472
      UniProtKB/Swiss-Prot
      O88887, Q9CQJ7, Q9Z2E6

    7. NM_001425542.1 → NP_001412471.1  securin isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL670472

    8. NM_001425543.1 → NP_001412472.1  securin isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL670472

    9. NM_001425544.1 → NP_001412473.1  securin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL670472

    10. NM_001425545.1 → NP_001412474.1  securin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL670472

    11. NM_001425546.1 → NP_001412475.1  securin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL670472

    12. NM_001425547.1 → NP_001412476.1  securin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL670472
      Related
      ENSMUSP00000020685.10, ENSMUST00000020685.10

    13. NM_001425548.1 → NP_001412477.1  securin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL670472

    14. NM_001425549.1 → NP_001412478.1  securin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL670472

    15. NM_001425550.1 → NP_001412479.1  securin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL670472

    16. NM_001425551.1 → NP_001412480.1  securin isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL670472

    17. NM_001425552.1 → NP_001412481.1  securin isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL670472

    18. NM_001425553.1 → NP_001412482.1  securin isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL670472

    19. NM_013917.4 → NP_038945.2  securin isoform 2

      See identical proteins and their annotated locations for NP_038945.2

      Status: VALIDATED

      Source sequence(s)
      AL670472
      Consensus CDS
      CCDS24556.1
      UniProtKB/TrEMBL
      Q3Y5K4
      Related
      ENSMUSP00000112841.2, ENSMUST00000117446.8
      Conserved Domains (1) summary
      pfam04856
      Location:1 → 173
      Securin; Securin sister-chromatid separation inhibitor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      43311097..43317417 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQJ7.1 GenPept UniProtKB/Swiss-Prot:Q9CQJ7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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