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    Cfp complement factor properdin [ Mus musculus (house mouse) ]

    Gene ID: 18636, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cfpprovided by MGI
    Official Full Name
    complement factor properdinprovided by MGI
    Primary source
    MGI:MGI:97545
    See related
    Ensembl:ENSMUSG00000001128 AllianceGenome:MGI:97545
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pfc; BCFG
    Summary
    Involved in complement activation, alternative pathway. Located in extracellular space and secretory granule. Is expressed in embryo; liver left lobe; and liver right lobe. Human ortholog(s) of this gene implicated in X-linked properdin deficiency. Orthologous to human CFP (complement factor properdin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in spleen adult (RPKM 86.6), mammary gland adult (RPKM 42.7) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cfp in Genome Data Viewer
    Location:
    X A1.3; X 16.44 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (20791693..20797794, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (20925454..20931555, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene microRNA 5617 Neighboring gene synapsin I Neighboring gene tissue inhibitor of metalloproteinase 1 Neighboring gene STARR-seq mESC enhancer starr_46887 Neighboring gene STARR-seq mESC enhancer starr_46888 Neighboring gene ELK1, member of ETS oncogene family Neighboring gene RIKEN cDNA A230072C01 gene Neighboring gene ubiquitously expressed prefoldin like chaperone

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (4)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    properdin
    Names
    complement factor P
    properdin factor, complement

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008823.4NP_032849.2  properdin precursor

      See identical proteins and their annotated locations for NP_032849.2

      Status: VALIDATED

      Source sequence(s)
      AK159291, AL671853, BY347370
      Consensus CDS
      CCDS30047.1
      UniProtKB/Swiss-Prot
      P11680, Q3TB98, Q3U779
      UniProtKB/TrEMBL
      A2AE15
      Related
      ENSMUSP00000001156.8, ENSMUST00000001156.8
      Conserved Domains (2) summary
      smart00209
      Location:192251
      TSP1; Thrombospondin type 1 repeats
      pfam00090
      Location:136184
      TSP_1; Thrombospondin type 1 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      20791693..20797794 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)