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    Rnf141 ring finger protein 141 [ Mus musculus (house mouse) ]

    Gene ID: 67150, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rnf141provided by MGI
    Official Full Name
    ring finger protein 141provided by MGI
    Primary source
    MGI:MGI:1914400
    See related
    Ensembl:ENSMUSG00000030788 AllianceGenome:MGI:1914400
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ZFP36; ZNF230; 2610110L04Rik
    Summary
    Predicted to enable ubiquitin-protein transferase activity. Acts upstream of or within regulation of DNA-templated transcription. Predicted to be located in membrane. Is expressed in several structures, including central nervous system; eye; genitourinary system; liver; and lung. Orthologous to human RNF141 (ring finger protein 141). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 5.5), subcutaneous fat pad adult (RPKM 5.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rnf141 in Genome Data Viewer
    Location:
    7 E3; 7 57.87 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (110398676..110443659, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (110799469..110844452, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA B430319F04 gene Neighboring gene adenosine monophosphate deaminase 3 Neighboring gene predicted gene, 39069 Neighboring gene STARR-positive B cell enhancer ABC_E2250 Neighboring gene lymphatic vessel endothelial hyaluronan receptor 1 Neighboring gene STARR-seq mESC enhancer starr_19833 Neighboring gene inositol 1,4,5-triphosphate receptor associated 1 Neighboring gene predicted gene 16336

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A new mutant transcript generated in Znf230 exon 2 knockout mice reveals a potential exon structure in the targeting vector sequence. Liu Y, et al. Acta Biochim Biophys Sin (Shanghai), 2013 Feb. PMID 23196134
    2. Expression and localization of the spermatogenesis-related gene, Znf230, in mouse testis and spermatozoa during postnatal development. Song H, et al. BMB Rep, 2008 Sep 30. PMID 18823591
    3. Molecular cloning and characterization of a mouse spermatogenesis-related ring finger gene znf230. Qiu W, et al. Biochem Biophys Res Commun, 2003 Jun 27. PMID 12804569
    4. High-throughput mapping of a dynamic signaling network in mammalian cells. Barrios-Rodiles M, et al. Science, 2005 Mar 11. PMID 15761153
    5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In summary, a potential exon structure in the targeting vector sequence involved in the expression of targeting Znf230 gene and disturbed the strategy of this gene-targeting experiment.
      Title: A new mutant transcript generated in Znf230 exon 2 knockout mice reveals a potential exon structure in the targeting vector sequence.
    2. The results indicate that Znf230 may play an important role in mouse spermatogenesis, including spermatogenic cell proliferation and sperm maturation, as well as motility and fertilization.
      Title: Expression and localization of the spermatogenesis-related gene, Znf230, in mouse testis and spermatozoa during postnatal development.
    3. may function as a testis specific transcription factor during mouse spermatogenesis
      Title: Molecular cloning and characterization of a mouse spermatogenesis-related ring finger gene znf230.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein autoubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein autoubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RING finger protein 141
    Names
    zinc finger protein 230

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418793.1 → NP_001405722.1  RING finger protein 141 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC122844, AC184052

    2. NM_001418794.1 → NP_001405723.1  RING finger protein 141 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122844, AC184052
      UniProtKB/TrEMBL
      H3BJB4

    3. NM_001418795.1 → NP_001405724.1  RING finger protein 141 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC122844, AC184052
      UniProtKB/TrEMBL
      H3BJB4
      Related
      ENSMUSP00000134917.2, ENSMUST00000177462.8

    4. NM_001418796.1 → NP_001405725.1  RING finger protein 141 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC122844, AC184052
      UniProtKB/TrEMBL
      H3BJU0

    5. NM_001418797.1 → NP_001405726.1  RING finger protein 141 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC122844, AC184052

    6. NM_001418798.1 → NP_001405727.1  RING finger protein 141 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC122844, AC184052
      UniProtKB/TrEMBL
      A0A1B0GT51
      Related
      ENSMUSP00000148202.2, ENSMUST00000176716.3

    7. NM_001418799.1 → NP_001405728.1  RING finger protein 141 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC122844, AC184052

    8. NM_001418800.1 → NP_001405729.1  RING finger protein 141 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC122844, AC184052
      UniProtKB/TrEMBL
      H3BJU0
      Related
      ENSMUSP00000135123.2, ENSMUST00000175981.8

    9. NM_001418801.1 → NP_001405730.1  RING finger protein 141 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC122844, AC184052
      UniProtKB/TrEMBL
      H3BJU0

    10. NM_001418802.1 → NP_001405731.1  RING finger protein 141 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122844, AC184052
      UniProtKB/Swiss-Prot
      Q99MB7, Q9D040, Q9D5C4, Q9D9L0

    11. NM_001418803.1 → NP_001405732.1  RING finger protein 141 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122844, AC184052
      UniProtKB/Swiss-Prot
      Q99MB7, Q9D040, Q9D5C4, Q9D9L0
      Related
      ENSMUSP00000102293.4, ENSMUST00000106682.10

    12. NM_001418804.1 → NP_001405733.1  RING finger protein 141 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122844, AC184052
      UniProtKB/Swiss-Prot
      Q99MB7, Q9D040, Q9D5C4, Q9D9L0

    13. NM_025999.4 → NP_080275.2  RING finger protein 141 isoform 1

      See identical proteins and their annotated locations for NP_080275.2

      Status: VALIDATED

      Source sequence(s)
      AC122844, AC184052
      Consensus CDS
      CCDS40086.1
      UniProtKB/Swiss-Prot
      Q99MB7, Q9D040, Q9D5C4, Q9D9L0
      UniProtKB/TrEMBL
      Q3U464
      Related
      ENSMUSP00000134781.2, ENSMUST00000177236.8
      Conserved Domains (1) summary
      cd16545
      Location:154 → 192
      RING-HC_RNF141; RING finger, HC subclass, found in RING finger protein 141 (RNF141) and similar proteins

    RNA

    1. NR_184819.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122844, AC184052

    2. NR_184820.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122844, AC184052

    3. NR_184821.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122844, AC184052

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      110398676..110443659 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242921.1 → XP_030098781.1  RING finger protein 141 isoform X2

      UniProtKB/TrEMBL
      H3BJB4
      Conserved Domains (1) summary
      cl17238
      Location:154 → 180
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    2. XM_036153378.1 → XP_036009271.1  RING finger protein 141 isoform X3

      UniProtKB/TrEMBL
      H3BJB4
      Conserved Domains (1) summary
      cl17238
      Location:154 → 180
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    RNA

    1. XR_869742.1 RNA Sequence

    2. XR_003946542.1 RNA Sequence

    3. XR_001777995.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99MB7.2 GenPept UniProtKB/Swiss-Prot:Q99MB7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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