Inha inhibin alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Inhaprovided by MGI
Official Full Name: inhibin alphaprovided by MGI
Primary source: MGI:MGI:96569
See related: Ensembl:ENSMUSG00000032968 AllianceGenome:MGI:96569
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate multiple peptide products, including the alpha subunit of the inhibin A and B protein complexes. These complexes negatively regulate follicle stimulating hormone secretion from the pituitary gland. Inhibins have also been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. Mice in which this gene has been ablated exhibit sex cord-stromal tumors and symptoms that mimic the human cancer cachexia syndrome. [provided by RefSeq, Aug 2016]
Expression: Biased expression in ovary adult (RPKM 2254.3) and adrenal adult (RPKM 71.2) See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 1 C4; 1 39.16 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (75483872..75487010)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (75507077..75510366)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Molecular Genomic Study of Inhibin Molecule Production through Granulosa Cell Gene Expression in Inhibin-Deficient Mice.
Title: Molecular Genomic Study of Inhibin Molecule Production through Granulosa Cell Gene Expression in Inhibin-Deficient Mice.
absence of the inhibin alpha-subunit has marginal effects on activins in the epididymis and vas deferens, and regression of these tissues is associated with androgen deficiency.
Title: Activin over-expression in the testis of mice lacking the inhibin α-subunit gene is associated with androgen deficiency and regression of the male reproductive tract.
These data suggest that activin-follistatin regulation may play a role during the development of Experimental autoimmune epididymo-orchitis.
Title: Testicular activin and follistatin levels are elevated during the course of experimental autoimmune epididymo-orchitis in mice.
This study tested the hypothesis that inhibins act in an autocrine manner on Leydig cells using a pre-pubertal Leydig cell line, TM3, as a model of immature Leydig cells.
Title: Endogenous inhibins regulate steroidogenesis in mouse TM3 Leydig cells by altering SMAD2 signalling.
The study is the first to identify an intratesticular role for inhibin/inhibin-alpha subunit, demonstrating that a threshold level of this protein is required for normal testis development and to sustain adult somatic testicular cell function.
Title: Murine Inhibin α-Subunit Haploinsufficiency Causes Transient Abnormalities in Prepubertal Testis Development Followed by Adult Testicular Decline.
inhibin is a broad regulatory marker in anterior pituitary cells
Title: Characterization of the mechanism of inhibin α-subunit gene in mouse anterior pituitary cells by RNA interference.
A novel role for GDF9 in causing reproductive defects and suppressing tumor initiation in the Inha(-/-) mouse model.
Title: GDF9 modulates the reproductive and tumor phenotype of female inha-null mice.
Data indicate that the inhibin-alpha promoter is activated synergistically by Wt1 and Sf1.
Title: Expression of inhibin-alpha is regulated synergistically by Wilms' tumor gene 1 (Wt1) and steroidogenic factor-1 (Sf1) in sertoli cells.
Inhibin alpha-subunit N terminus interacts with activin type IB receptor to disrupt activin signaling.
Title: Inhibin α-subunit N terminus interacts with activin type IB receptor to disrupt activin signaling.
relationship between inhibin and Sertoli cell activity
Title: Action mechanism of inhibin α-subunit on the development of Sertoli cells and first wave of spermatogenesis in mice.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (1) 1 citation

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

REN53413 (e-PCR)
- UniSTS:378213

D9Wox10 (e-PCR)
- UniSTS:118138

Inha (e-PCR), detects polymorphism
- UniSTS:118138

C87829 (e-PCR)
- UniSTS:207229

D1Mcg8 (e-PCR), detects polymorphism
- UniSTS:142241

D1Mit131 (e-PCR), detects polymorphism
- UniSTS:128466

UniSTS:143587 (e-PCR)
- UniSTS:143587

Inha (e-PCR), detects polymorphism
- UniSTS:143587

AW555078 (e-PCR)
- UniSTS:178415

ECD17211 (e-PCR)
- UniSTS:298224

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables inhibin binding	IEA Inferred from Electronic Annotation more info
enables inhibin binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in hemoglobin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in hemoglobin biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in male gonad development	IEA Inferred from Electronic Annotation more info
involved_in male gonad development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of follicle-stimulating hormone secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of follicle-stimulating hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in ovarian follicle development	IEA Inferred from Electronic Annotation more info
involved_in ovarian follicle development	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of inhibin A complex	IEA Inferred from Electronic Annotation more info
part_of inhibin A complex	ISO Inferred from Sequence Orthology more info
part_of inhibin B complex	IEA Inferred from Electronic Annotation more info
part_of inhibin B complex	ISO Inferred from Sequence Orthology more info
part_of inhibin-betaglycan-ActRII complex	IEA Inferred from Electronic Annotation more info
part_of inhibin-betaglycan-ActRII complex	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in photoreceptor inner segment	IEA Inferred from Electronic Annotation more info
located_in photoreceptor inner segment	ISO Inferred from Sequence Orthology more info
located_in photoreceptor outer segment	IEA Inferred from Electronic Annotation more info
located_in photoreceptor outer segment	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: inhibin alpha chain

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001329843.2 → NP_001316772.1 inhibin alpha chain isoform 2

Status: VALIDATED

Source sequence(s)

AC115011
NM_010564.6 → NP_034694.3 inhibin alpha chain isoform 1 preproprotein

See identical proteins and their annotated locations for NP_034694.3

Status: VALIDATED

Source sequence(s)

AC115011

Consensus CDS

CCDS15078.1

UniProtKB/Swiss-Prot

Q04997, Q6GTG7

Related

ENSMUSP00000040310.5, ENSMUST00000037330.5

Conserved Domains (1) summary

cl02510
Location:263 → 366

TGF_beta; Transforming growth factor beta like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

75483872..75487010

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011238675.3 → XP_011236977.1 inhibin alpha chain isoform X1

Conserved Domains (1) summary

cl40434
Location:181 → 284

TGF_beta_SF; transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily