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    Nsmce3 NSE3 homolog, SMC5-SMC6 complex component [ Mus musculus (house mouse) ]

    Gene ID: 66647, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nsmce3provided by MGI
    Official Full Name
    NSE3 homolog, SMC5-SMC6 complex componentprovided by MGI
    Primary source
    MGI:MGI:1913897
    See related
    Ensembl:ENSMUSG00000070520 AllianceGenome:MGI:1913897
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HCA4; Ndnl2; Mageg1; mage-g1; 5730494G16Rik
    Summary
    Predicted to enable protein dimerization activity. Acts upstream of or within regulation of DNA-templated transcription. Predicted to be located in chromosome, telomeric region and cytoplasm. Predicted to be part of Smc5-Smc6 complex. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; embryo mesenchyme; future brain; genitourinary system; and musculature. Orthologous to human NSMCE3 (NSE3 homolog, SMC5-SMC6 complex component). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Nsmce3 in Genome Data Viewer
    Location:
    7 C; 7 34.77 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (64521430..64522788, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (64871682..64873040, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4931 Neighboring gene methylmalonyl CoA epimerase Neighboring gene amyloid beta precursor protein binding family A member 2 Neighboring gene STARR-seq mESC enhancer starr_19041 Neighboring gene STARR-seq mESC enhancer starr_19042 Neighboring gene endosomal transmembrane epsin interactor 2 Neighboring gene STARR-seq mESC enhancer starr_19043 Neighboring gene STARR-seq mESC enhancer starr_19044 Neighboring gene STARR-seq mESC enhancer starr_19045 Neighboring gene STARR-seq mESC enhancer starr_19046 Neighboring gene STARR-seq mESC enhancer starr_19047 Neighboring gene predicted gene, 51521 Neighboring gene STARR-seq mESC enhancer starr_19050 Neighboring gene STARR-seq mESC enhancer starr_19051 Neighboring gene predicted gene, 32963

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein dimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein dimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to UV ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to UV ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to hydroxyurea ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hydroxyurea ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to radiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to radiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Smc5-Smc6 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Smc5-Smc6 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    non-structural maintenance of chromosomes element 3 homolog
    Names
    MAGE-G1 antigen
    melanoma antigen, family G, 1
    melanoma-associated antigen G1
    necdin-like 2
    necdin-like protein 2
    non-SMC element 3 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023239.5NP_075728.1  non-structural maintenance of chromosomes element 3 homolog

      See identical proteins and their annotated locations for NP_075728.1

      Status: VALIDATED

      Source sequence(s)
      AC135860, AK017727
      Consensus CDS
      CCDS21337.1
      UniProtKB/Swiss-Prot
      Q569V7, Q9CPR8, Q9D378
      UniProtKB/TrEMBL
      Q6KAQ0
      Related
      ENSMUSP00000091889.3, ENSMUST00000094331.5
      Conserved Domains (1) summary
      pfam01454
      Location:66235
      MAGE; MAGE family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      64521430..64522788 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)