Taok3 TAO kinase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Taok3provided by MGI
Official Full Name: TAO kinase 3provided by MGI
Primary source: MGI:MGI:3041177
See related: Ensembl:ENSMUSG00000061288 AllianceGenome:MGI:3041177
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A130052D22; 2900006A08Rik; A430105I05Rik
Summary: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including intracellular signal transduction; protein autophosphorylation; and regulation of MAPK cascade. Predicted to be active in cytoplasm. Is expressed in cerebral cortex ventricular layer; cortical plate; and renal vasculature. Orthologous to human TAOK3 (TAO kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in liver E14 (RPKM 7.8), liver E14.5 (RPKM 6.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 56.88 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (117258180..117413283)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (117120111..117275101)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The induction of SHP-1 degradation by TAOK3 ensures the responsiveness of T cells to TCR stimulation.
Title: The induction of SHP-1 degradation by TAOK3 ensures the responsiveness of T cells to TCR stimulation.
Knockout of STE20-type kinase TAOK3 does not attenuate diet-induced NAFLD development in mice.
Title: Knockout of STE20-type kinase TAOK3 does not attenuate diet-induced NAFLD development in mice.
STE20 kinase TAOK3 regulates type 2 immunity and metabolism in obesity.
Title: STE20 kinase TAOK3 regulates type 2 immunity and metabolism in obesity.
TAOK3 is a MAP3K contributing to osteoblast differentiation and skeletal mineralization.
Title: TAOK3 is a MAP3K contributing to osteoblast differentiation and skeletal mineralization.
this study shows that during positive selection in the spleen, B-cell receptor signaling causes immature type 1 transitional B cells to become receptive to Notch ligands via Taok3-mediated surface expression of ADAM10
Title: Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation
Gene trapped (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fd25g06.y1 (e-PCR)
- UniSTS:195376

AU046392 (e-PCR)
- UniSTS:111484

M-09391 (e-PCR)
- UniSTS:186269

BE692243 (e-PCR)
- UniSTS:207860

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in mitotic G2 DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in mitotic G2 DNA damage checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in neuron projection morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JUN kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress-activated MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine/threonine-protein kinase TAO3

Names: thousand and one amino acid protein 3

NP_001074777.1

EC 2.7.11.1

NP_001186614.1

EC 2.7.11.1

NP_899129.2

EC 2.7.11.1

XP_006530448.1

EC 2.7.11.1

XP_011246521.1

EC 2.7.11.1

XP_011246522.1

EC 2.7.11.1

XP_011246523.1

EC 2.7.11.1

XP_030110461.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081308.2 → NP_001074777.1 serine/threonine-protein kinase TAO3

See identical proteins and their annotated locations for NP_001074777.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses a different segment and lacks an alternate exon in its 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.

Source sequence(s)

AA182196, AC110234, AK042181, BM225493, BY201674, CK625948

Consensus CDS

CCDS39233.1

UniProtKB/Swiss-Prot

Q3V3B3, Q8BYC6

UniProtKB/TrEMBL

B2RY27

Related

ENSMUSP00000090565.6, ENSMUST00000092889.12

Conserved Domains (2) summary

PTZ00121
Location:415 → 881

PTZ00121; MAEBL; Provisional

cl21453
Location:2 → 314

PKc_like; Protein Kinases, catalytic domain
NM_001199685.1 → NP_001186614.1 serine/threonine-protein kinase TAO3

See identical proteins and their annotated locations for NP_001186614.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.

Source sequence(s)

AA182196, AC110234, AK040531, AK042181, BC158072

Consensus CDS

CCDS39233.1

UniProtKB/Swiss-Prot

Q3V3B3, Q8BYC6

UniProtKB/TrEMBL

B2RY27

Related

ENSMUSP00000107609.2, ENSMUST00000111978.8

Conserved Domains (2) summary

PTZ00121
Location:415 → 881

PTZ00121; MAEBL; Provisional

cl21453
Location:2 → 314

PKc_like; Protein Kinases, catalytic domain
NM_183306.2 → NP_899129.2 serine/threonine-protein kinase TAO3

See identical proteins and their annotated locations for NP_899129.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses a different segment for its 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.

Source sequence(s)

AA182196, AC110234, AK042181, BM225493, BY201674, CK625948

Consensus CDS

CCDS39233.1

UniProtKB/Swiss-Prot

Q3V3B3, Q8BYC6

UniProtKB/TrEMBL

B2RY27

Related

ENSMUSP00000136750.2, ENSMUST00000179276.8

Conserved Domains (2) summary

PTZ00121
Location:415 → 881

PTZ00121; MAEBL; Provisional

cl21453
Location:2 → 314

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

117258180..117413283

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006530385.5 → XP_006530448.1 serine/threonine-protein kinase TAO3 isoform X1

See identical proteins and their annotated locations for XP_006530448.1

UniProtKB/Swiss-Prot

Q3V3B3, Q8BYC6

UniProtKB/TrEMBL

B2RY27

Conserved Domains (2) summary

PTZ00121
Location:415 → 881

PTZ00121; MAEBL; Provisional

cl21453
Location:2 → 314

PKc_like; Protein Kinases, catalytic domain
XM_011248219.4 → XP_011246521.1 serine/threonine-protein kinase TAO3 isoform X1

See identical proteins and their annotated locations for XP_011246521.1

UniProtKB/Swiss-Prot

Q3V3B3, Q8BYC6

UniProtKB/TrEMBL

B2RY27

Conserved Domains (2) summary

PTZ00121
Location:415 → 881

PTZ00121; MAEBL; Provisional

cl21453
Location:2 → 314

PKc_like; Protein Kinases, catalytic domain
XM_011248220.4 → XP_011246522.1 serine/threonine-protein kinase TAO3 isoform X1

See identical proteins and their annotated locations for XP_011246522.1

UniProtKB/Swiss-Prot

Q3V3B3, Q8BYC6

UniProtKB/TrEMBL

B2RY27

Conserved Domains (2) summary

PTZ00121
Location:415 → 881

PTZ00121; MAEBL; Provisional

cl21453
Location:2 → 314

PKc_like; Protein Kinases, catalytic domain
XM_011248221.4 → XP_011246523.1 serine/threonine-protein kinase TAO3 isoform X2

UniProtKB/TrEMBL

B2RY27

Conserved Domains (2) summary

PTZ00121
Location:245 → 711

PTZ00121; MAEBL; Provisional

cl21453
Location:1 → 144

PKc_like; Protein Kinases, catalytic domain
XM_030254601.2 → XP_030110461.1 serine/threonine-protein kinase TAO3 isoform X2

UniProtKB/TrEMBL

B2RY27

Conserved Domains (2) summary

PTZ00121
Location:245 → 711

PTZ00121; MAEBL; Provisional

cl21453
Location:1 → 144

PKc_like; Protein Kinases, catalytic domain