Pelo pelota mRNA surveillance and ribosome rescue factor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Peloprovided by MGI
Official Full Name: pelota mRNA surveillance and ribosome rescue factorprovided by MGI
Primary source: MGI:MGI:2145154
See related: Ensembl:ENSMUSG00000042275 AllianceGenome:MGI:2145154
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable ribosome binding activity and stalled ribosome sensor activity. Acts upstream of or within several processes, including inner cell mass cell proliferation; mesenchymal to epithelial transition; and positive regulation of BMP signaling pathway. Predicted to be part of Dom34-Hbs1 complex. Predicted to be active in cytosolic ribosome. Is expressed in several structures, including central nervous system; genitourinary system; limb muscle; orbito-sphenoid; and spleen. Orthologous to human PELO (pelota mRNA surveillance and ribosome rescue factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in lung adult (RPKM 16.1), bladder adult (RPKM 15.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 D2.2; 13 64.61 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (115224891..115226694, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (115088355..115090158, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PELO facilitates PLK1-induced the ubiquitination and degradation of Smad4 and promotes the progression of prostate cancer.
Title: PELO facilitates PLK1-induced the ubiquitination and degradation of Smad4 and promotes the progression of prostate cancer.
Defects in translation-dependent quality control pathways lead to convergent molecular and neurodevelopmental pathology.
Title: Defects in translation-dependent quality control pathways lead to convergent molecular and neurodevelopmental pathology.
Perturbed differentiation of murine embryonic stem cells upon Pelota deletion due to dysregulated FOXO1/beta-catenin signaling.
Title: Perturbed differentiation of murine embryonic stem cells upon Pelota deletion due to dysregulated FOXO1/β-catenin signaling.
increased activity of the PI3K/AKT signaling pathway in Pelo-deficient skin might conflict with the dephosphorylation of profilaggrin and thereby affect its proper processing into filaggrin monomers and ultimately the epidermal differentiation
Title: Pelota Regulates Epidermal Differentiation by Modulating BMP and PI3K/AKT Signaling Pathways.
These results suggest that PELO negatively regulates the PI3K/AKT pathway and that the enhanced activity of PI3K/AKT and subsequent FOXO1 inhibition are responsible for the impaired development of spermatogonial stem cells in mutant testes.
Title: Pelota mediates gonocyte maturation and maintenance of spermatogonial stem cells in mouse testes.
Results indicate that PELO plays an important role in the establishment of pluripotency and differentiation of ESCs into ExEn lineage through activation of BMP signaling.
Title: Pelota regulates the development of extraembryonic endoderm through activation of bone morphogenetic protein (BMP) signaling.
these results not only define GTPBP2 as a ribosome rescue factor but also unmask the disease potential of mutations in nuclear-encoded tRNA genes.
Title: RNA function. Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration.
Pelo is required for the maintenance of genomic stability
Title: Disruption of the pelota gene causes early embryonic lethality and defects in cell cycle progression.
cDNA cloning, genomic structure, and chromosomal localization
Title: Mouse pelota gene (Pelo): cDNA cloning, genomic structure, and chromosomal localization.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Pelo (e-PCR), detects polymorphism
- UniSTS:243340

PMC141158P1 (e-PCR)
- UniSTS:270996

RH124904 (e-PCR)
- UniSTS:161726

AI852218 (e-PCR)
- UniSTS:164542

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribosome binding	ISO Inferred from Sequence Orthology more info
enables ribosome binding	ISS Inferred from Sequence or Structural Similarity more info
enables stalled ribosome sensor activity	IEA Inferred from Electronic Annotation more info
enables stalled ribosome sensor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in RNA surveillance	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endoderm development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within endoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner cell mass cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mesenchymal to epithelial transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nonfunctional rRNA decay	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear-transcribed mRNA catabolic process, no-go decay	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear-transcribed mRNA catabolic process, no-go decay	ISO Inferred from Sequence Orthology more info
involved_in nuclear-transcribed mRNA catabolic process, no-go decay	ISS Inferred from Sequence or Structural Similarity more info
involved_in nuclear-transcribed mRNA catabolic process, non-stop decay	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in rescue of stalled ribosome	ISO Inferred from Sequence Orthology more info
involved_in rescue of stalled ribosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in ribosome disassembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosome disassembly	ISO Inferred from Sequence Orthology more info
involved_in ribosome disassembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Dom34-Hbs1 complex	ISO Inferred from Sequence Orthology more info
part_of Dom34-Hbs1 complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in cytosolic ribosome	IEA Inferred from Electronic Annotation more info
is_active_in cytosolic ribosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein pelota homolog

Names: pelota homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134058.3 → NP_598819.2 protein pelota homolog

See identical proteins and their annotated locations for NP_598819.2

Status: VALIDATED

Source sequence(s)

AC175538, AI854576, BB767039, BC050209

Consensus CDS

CCDS26788.1

UniProtKB/Swiss-Prot

Q3TCN0, Q6PG91, Q80X73, Q91UZ2

UniProtKB/TrEMBL

Q3THL5

Related

ENSMUSP00000104849.4, ENSMUST00000109226.5

Conserved Domains (4) summary

COG1537
Location:1 → 371

PelA; Stalled ribosome rescue protein Dom34, pelota family [Translation, ribosomal structure and biogenesis]

pfam03463
Location:1 → 128

eRF1_1; eRF1 domain 1

pfam03464
Location:136 → 268

eRF1_2; eRF1 domain 2

pfam03465
Location:271 → 370

eRF1_3; eRF1 domain 3