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    C1qc complement component 1, q subcomponent, C chain [ Mus musculus (house mouse) ]

    Gene ID: 12262, updated on 27-Nov-2024

    Summary

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    Official Symbol
    C1qcprovided by MGI
    Official Full Name
    complement component 1, q subcomponent, C chainprovided by MGI
    Primary source
    MGI:MGI:88225
    See related
    Ensembl:ENSMUSG00000036896 AllianceGenome:MGI:88225
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Adib; C1qg; Ciqc
    Summary
    Involved in synapse pruning. Located in postsynapse. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic membrane and extrinsic component of presynaptic membrane. Is expressed in blood vessel; dentate gyrus subgranular zone; and retina. Orthologous to human C1QC (complement C1q C chain). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in spleen adult (RPKM 175.9), mammary gland adult (RPKM 135.8) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See C1qc in Genome Data Viewer
    Location:
    4 D3; 4 69.05 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (136617115..136620225, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (136889801..136892936, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene Eph receptor B2 Neighboring gene predicted gene, 31536 Neighboring gene STARR-seq mESC enhancer starr_11774 Neighboring gene complement component 1, q subcomponent, beta polypeptide Neighboring gene complement component 1, q subcomponent, alpha polypeptide Neighboring gene Eph receptor A8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Isolation, sequence analysis and characterization of cDNA clones coding for the C chain of mouse C1q. Sequence similarity of complement subcomponent C1q, collagen type VIII and type X and precerebellin. Petry F, et al. Eur J Biochem, 1992 Oct 1. PMID 1396691
    2. Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer's disease mouse models. Dejanovic B, et al. Nat Aging, 2022 Sep. PMID 37118504, Free PMC Article
    3. Complement in breast milk modifies offspring gut microbiota to promote infant health. Xu D, et al. Cell, 2024 Feb 1. PMID 38242132,
    4. C1q-binding proteins and C1q receptors. Nicholson-Weller A, et al. Curr Opin Immunol, 1999 Feb. PMID 10047536
    5. C1q regulatory region polymorphism down-regulating murine c1q protein levels with linkage to lupus nephritis. Miura-Shimura Y, et al. J Immunol, 2002 Aug 1. PMID 12133956

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of the molecular mechanisms for synchronized transcription of three complement C1q subunit genes (A, B and C) in dendritic cells and macrophages
      Title: Molecular mechanisms for synchronized transcription of three complement C1q subunit genes in dendritic cells and macrophages.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in complement activation, classical pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in complement activation, classical pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of granulocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of granulocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of macrophage differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of macrophage differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synapse pruning IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of complement component C1 complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of complement component C1q complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in extracellular space HDA PubMed 
    is_active_in extrinsic component of postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extrinsic component of presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynapse IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    complement C1q subcomponent subunit C
    Names
    adiponectin b
    complement component 1, q subcomponent, c polypeptide
    complement component 1, q subcomponent, gamma polypeptide

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419959.1 → NP_001406888.1  complement C1q subcomponent subunit C precursor

      Status: VALIDATED

      Source sequence(s)
      AL627214
      UniProtKB/Swiss-Prot
      Q02105, Q6DI63

    2. NM_007574.3 → NP_031600.2  complement C1q subcomponent subunit C precursor

      See identical proteins and their annotated locations for NP_031600.2

      Status: VALIDATED

      Source sequence(s)
      AL627214
      Consensus CDS
      CCDS18811.1
      UniProtKB/Swiss-Prot
      Q02105, Q6DI63
      UniProtKB/TrEMBL
      A0A3B0INZ4
      Related
      ENSMUSP00000036747.6, ENSMUST00000046332.6
      Conserved Domains (2) summary
      smart00110
      Location:114 → 246
      C1Q; Complement component C1q domain
      pfam01391
      Location:44 → 92
      Collagen; Collagen triple helix repeat (20 copies)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      136617115..136620225 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02105.2 GenPept UniProtKB/Swiss-Prot:Q02105

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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