Uncx UNC homeobox [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Uncxprovided by MGI
Official Full Name: UNC homeoboxprovided by MGI
Primary source: MGI:MGI:108013
See related: Ensembl:ENSMUSG00000029546 AllianceGenome:MGI:108013
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Chx4; Uncx4.1
Summary: Predicted to enable sequence-specific double-stranded DNA binding activity. Acts upstream of or within several processes, including cartilage condensation; central nervous system development; and common myeloid progenitor cell proliferation. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; musculoskeletal system; and sensory organ. Orthologous to human UNCX (UNC homeobox). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in CNS E11.5 (RPKM 16.6), whole brain E14.5 (RPKM 10.7) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 78.75 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (139529620..139533934)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (139543865..139548179)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Uncx acts downstream of neural determination factors to broadly control transcriptional mechanisms used by progenitor cells to specify the phenotype of the olfactory sensory neuron.
Title: Uncx regulates proliferation of neural progenitor cells and neuronal survival in the olfactory epithelium.
Uncx4.1 might play an important role during glutamatergic neuronal differentiation in the mouse midbrain.
Title: The transcription factor Uncx4.1 acts in a short window of midbrain dopaminergic neuron differentiation.
UNCX acts downstream of neural determination factors to broadly control transcriptional mechanisms used by neural progenitor cells to specify neural phenotypes
Title: Uncx regulates proliferation of neural progenitor cells and neuronal survival in the olfactory epithelium.
We examined Lunatic Fringe (Lfng) and Uncx4.1 expression in the presomitic mesoderm (PSM) and somites of Jsr-mutant (CKH-Jsr/+) embryos to elucidate pathogenesis of the Jsr mutation.
Title: Examination of the Lunatic fringe and Uncx4.1 expression by whole-mount in situ hybridization in the embryo of the CKH-Jsr (jumbled spine and ribs) mouse.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

General gene information

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Markers

Uncx (e-PCR), detects polymorphism
- UniSTS:547385

Uncx4.1 (e-PCR), detects polymorphism
- UniSTS:144731

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cartilage condensation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within common myeloid progenitor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dorsal spinal cord development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within olfactory bulb interneuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pattern specification process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: homeobox protein unc-4 homolog

Names: Unc4.1 homeobox; homeobox protein Uncx4.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013702.4 → NP_038730.1 homeobox protein unc-4 homolog

See identical proteins and their annotated locations for NP_038730.1

Status: VALIDATED

Source sequence(s)

AC144902

Consensus CDS

CCDS19813.1

UniProtKB/Swiss-Prot

O08934, P70457, Q78DU3

Related

ENSMUSP00000134067.3, ENSMUST00000172997.3

Conserved Domains (1) summary

pfam00046
Location:112 → 165

Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

139529620..139533934

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030254367.1 → XP_030110227.1 homeobox protein unc-4 homolog isoform X1

Conserved Domains (2) summary

PHA03247
Location:99 → 334

PHA03247; large tegument protein UL36; Provisional

PRK12270
Location:243 → 337

kgd; multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit
XM_030254366.1 → XP_030110226.1 homeobox protein unc-4 homolog isoform X1

Conserved Domains (2) summary

PHA03247
Location:99 → 334

PHA03247; large tegument protein UL36; Provisional

PRK12270
Location:243 → 337

kgd; multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit