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    Fech ferrochelatase [ Mus musculus (house mouse) ]

    Gene ID: 14151, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fechprovided by MGI
    Official Full Name
    ferrochelataseprovided by MGI
    Primary source
    MGI:MGI:95513
    See related
    Ensembl:ENSMUSG00000024588 AllianceGenome:MGI:95513
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fcl; fch
    Summary
    Enables several functions, including ferrochelatase activity; heme binding activity; and iron-responsive element binding activity. Involved in heme A biosynthetic process; heme B biosynthetic process; and heme O biosynthetic process. Acts upstream of or within several processes, including multicellular organismal-level iron ion homeostasis; regulation of protein metabolic process; and very-low-density lipoprotein particle assembly. Located in mitochondrial inner membrane. Is active in mitochondrial matrix. Is expressed in several structures, including choroid plexus; heart; integumental system; liver and biliary system; and respiratory system. Used to study erythropoietic protoporphyria. Human ortholog(s) of this gene implicated in cutaneous porphyria and erythropoietic protoporphyria. Orthologous to human FECH (ferrochelatase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver E14.5 (RPKM 171.3), liver E14 (RPKM 167.9) and 18 other tissues See more
    Orthologs
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    Genomic context

    See Fech in Genome Data Viewer
    Location:
    18 E1; 18 37.43 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (64589613..64622169, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (64456542..64489098, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36804 Neighboring gene S-adenosylmethionine decarboxylase, pseudogene 3 Neighboring gene STARR-seq mESC enhancer starr_44807 Neighboring gene STARR-positive B cell enhancer ABC_E10997 Neighboring gene STARR-positive B cell enhancer ABC_E8722 Neighboring gene asparaginyl-tRNA synthetase 1 Neighboring gene ATPase, class I, type 8B, member 1 Neighboring gene STARR-seq mESC enhancer starr_44809 Neighboring gene predicted gene 6978

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ferrochelatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ferrochelatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ferrochelatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ferrochelatase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables heme binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables iron ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables iron-responsive element binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables tetrapyrrole binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to dexamethasone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cholesterol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within detection of UV IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heme A biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heme B biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heme O biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heme biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within heme biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within heme biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heme biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within heme biosynthetic process TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within porphyrin-containing compound biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protoporphyrinogen IX metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in protoporphyrinogen IX metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of eIF2 alpha phosphorylation by heme IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of eIF2 alpha phosphorylation by heme IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of hemoglobin biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in response to arsenic-containing substance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to insecticide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to lead ion IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to light stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to methylmercury IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to platinum ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within very-low-density lipoprotein particle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    ferrochelatase, mitochondrial
    Names
    heme synthase
    heme synthetase
    protoheme ferro-lyase
    NP_001334984.1
    NP_032024.2
    XP_036016877.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001348055.2NP_001334984.1  ferrochelatase, mitochondrial isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks an in-frame portion of the 5' coding region, and uses a downstream start codon compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC102106, AC102268, AEKQ02072540
      UniProtKB/TrEMBL
      F6T2S0
      Related
      ENSMUSP00000025484.9, ENSMUST00000025484.9
      Conserved Domains (1) summary
      pfam00762
      Location:1317
      Ferrochelatase
    2. NM_007998.8NP_032024.2  ferrochelatase, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_032024.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC102106, AC102268, AEKQ02072540
      Consensus CDS
      CCDS29303.1
      UniProtKB/Swiss-Prot
      P22315, Q544X6
      UniProtKB/TrEMBL
      Q3UC49
      Related
      ENSMUSP00000157791.2, ENSMUST00000236586.3
      Conserved Domains (3) summary
      cd00419
      Location:234371
      Ferrochelatase_C; Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...
      cd03411
      Location:68229
      Ferrochelatase_N; Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...
      pfam00762
      Location:68388
      Ferrochelatase; Ferrochelatase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      64589613..64622169 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160984.1XP_036016877.1  ferrochelatase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      F6T2S0
      Conserved Domains (1) summary
      pfam00762
      Location:1317
      Ferrochelatase

    RNA

    1. XR_385974.5 RNA Sequence