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    Mrps21 mitochondrial ribosomal protein S21 [ Mus musculus (house mouse) ]

    Gene ID: 66292, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mrps21provided by MGI
    Official Full Name
    mitochondrial ribosomal protein S21provided by MGI
    Primary source
    MGI:MGI:1913542
    See related
    Ensembl:ENSMUSG00000054312 AllianceGenome:MGI:1913542
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    S21mt; 1810031B19Rik
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Located in mitochondrial inner membrane. Is expressed in several structures, including early conceptus; gonad; heart; liver; and metanephros. Orthologous to human MRPS21 (mitochondrial ribosomal protein S21). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 59.5), CNS E11.5 (RPKM 58.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mrps21 in Genome Data Viewer
    Location:
    3 F2.1; 3 41.36 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95769946..95778826, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95862634..95871514, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene regulation of nuclear pre-mRNA domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_08396 Neighboring gene predicted gene, 29948 Neighboring gene pre-mRNA processing factor 3 Neighboring gene STARR-positive B cell enhancer ABC_E10199 Neighboring gene RIKEN cDNA C920021L13 gene Neighboring gene STARR-positive B cell enhancer ABC_E9562 Neighboring gene cDNA sequence BC028528 Neighboring gene circadian associated repressor of transcription Neighboring gene STARR-positive B cell enhancer ABC_E2673 Neighboring gene aph1 homolog A, gamma secretase subunit Neighboring gene carbonic anhydrase 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mammalian mitochondrial ribosomal small subunit (MRPS) genes: A putative role in human disease. Gopisetty G, et al. Gene, 2016 Sep 1. PMID 27170550
    2. Ribosome. The structure of the human mitochondrial ribosome. Amunts A, et al. Science, 2015 Apr 3. PMID 25838379, Free PMC Article
    3. Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit. Suzuki T, et al. J Biol Chem, 2001 Aug 31. PMID 11402041
    4. Expression analysis of mammalian mitochondrial ribosomal protein genes. Cheong A, et al. Gene Expr Patterns, 2020 Dec. PMID 32987154, Free PMC Article
    5. Structure and Function of the Mitochondrial Ribosome. Greber BJ, et al. Annu Rev Biochem, 2016 Jun 2. PMID 27023846

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of ribosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of mitochondrial small ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial small ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of mitochondrial small ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    small ribosomal subunit protein bS21m
    Names
    28S ribosomal protein S21, mitochondrial
    NP_001342688.1
    NP_510964.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355759.1 → NP_001342688.1  small ribosomal subunit protein bS21m

      Status: VALIDATED

      Source sequence(s)
      AC092855, AC093317, AK008265
      Consensus CDS
      CCDS38550.1
      UniProtKB/Swiss-Prot
      P58059
      UniProtKB/TrEMBL
      Q059G7
      Related
      ENSMUSP00000066990.5, ENSMUST00000067298.5
      Conserved Domains (1) summary
      TIGR00030
      Location:10 → 66
      S21p; ribosomal protein S21

    2. NM_078479.4 → NP_510964.1  small ribosomal subunit protein bS21m

      See identical proteins and their annotated locations for NP_510964.1

      Status: VALIDATED

      Source sequence(s)
      AC092855, AC093317, BC027546
      Consensus CDS
      CCDS38550.1
      UniProtKB/Swiss-Prot
      P58059
      UniProtKB/TrEMBL
      Q059G7
      Conserved Domains (1) summary
      TIGR00030
      Location:10 → 66
      S21p; ribosomal protein S21

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      95769946..95778826 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P58059.1 GenPept UniProtKB/Swiss-Prot:P58059

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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