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    Gzmm granzyme M (lymphocyte met-ase 1) [ Mus musculus (house mouse) ]

    Gene ID: 16904, updated on 3-Dec-2024

    Summary

    Official Symbol
    Gzmmprovided by MGI
    Official Full Name
    granzyme M (lymphocyte met-ase 1)provided by MGI
    Primary source
    MGI:MGI:99549
    See related
    Ensembl:ENSMUSG00000054206 AllianceGenome:MGI:99549
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lmet1; MMET-1
    Summary
    The protein encoded by this gene is a member of a family of cytotoxic lymphocyte serine proteases called granzymes, which are expressed by cytotoxic T lymphocytes and natural killer cells. This protein belongs to a subfamily of granzymes that cleave after methionine residues. Natural killer cell development, homeostasis and cytotoxicity are normal in mice deficient for this gene, but they demonstrate increased susceptibility to murine cytomegalovirus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
    Expression
    Ubiquitous expression in heart adult (RPKM 1.8), placenta adult (RPKM 0.9) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Gzmm in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79524854..79531095)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (79689020..79695261)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene tubulin polyglutamylase complex subunit 1 Neighboring gene STARR-positive B cell enhancer ABC_E3896 Neighboring gene cell division cycle 34 Neighboring gene STARR-positive B cell enhancer ABC_E10624 Neighboring gene predicted gene, 25794 Neighboring gene basigin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine-type peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within T cell mediated cytotoxicity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    granzyme M
    Names
    lymphoctye Met-ase 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302485.1NP_001289414.1  granzyme M isoform 2 precursor

      See identical proteins and their annotated locations for NP_001289414.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) utilizes an alternate in-frame splice site in the 5' coding region. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC151828, BG082217, CD742060
      UniProtKB/TrEMBL
      B7ZP17
      Conserved Domains (2) summary
      smart00020
      Location:26250
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:26253
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    2. NM_001302499.2NP_001289428.1  granzyme M isoform 3

      See identical proteins and their annotated locations for NP_001289428.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains a distinct 5' UTR, lacks exons in the coding region, and utilizes a downstream start codon compared to variant 1. It encodes isoform 3, which is shorter than isoform 1. Variants 3 and 6-9 all encode the same isoform (3).
      Source sequence(s)
      AC151828
      UniProtKB/TrEMBL
      Q9R1W7
      Related
      ENSMUST00000151213.2
      Conserved Domains (1) summary
      cl21584
      Location:2100
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    3. NM_001428556.1NP_001415485.1  granzyme M isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC151828
    4. NM_001428558.1NP_001415487.1  granzyme M isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC151828
      UniProtKB/TrEMBL
      Q9R1W7
    5. NM_001428559.1NP_001415488.1  granzyme M isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC151828
      UniProtKB/TrEMBL
      Q9R1W7
    6. NM_001428560.1NP_001415489.1  granzyme M isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC151828
      UniProtKB/TrEMBL
      Q9R1W7
    7. NM_001428561.1NP_001415490.1  granzyme M isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC151828
      UniProtKB/TrEMBL
      Q9R1W7
    8. NM_008504.3NP_032530.1  granzyme M isoform 1 precursor

      See identical proteins and their annotated locations for NP_032530.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC151828, BG082217, CD742060
      Consensus CDS
      CCDS23984.1
      UniProtKB/TrEMBL
      O08643
      Related
      ENSMUSP00000020549.3, ENSMUST00000020549.4
      Conserved Domains (2) summary
      smart00020
      Location:27251
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:27254
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RNA

    1. NR_126325.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC151828, BE859680, BG082217, CD742060

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      79524854..79531095
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313816.3XP_017169305.1  granzyme M isoform X1

      Conserved Domains (1) summary
      cl21584
      Location:2100
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    2. XM_006513277.4XP_006513340.1  granzyme M isoform X1

      Conserved Domains (1) summary
      cl21584
      Location:2100
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...