Ddx50 DExD box helicase 50 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ddx50provided by MGI
Official Full Name: DExD box helicase 50provided by MGI
Primary source: MGI:MGI:2182303
See related: Ensembl:ENSMUSG00000020076 AllianceGenome:MGI:2182303
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GU2; RH-II; 4933429B04Rik; 8430408E17Rik
Summary: Predicted to enable RNA helicase activity and mRNA binding activity. Predicted to be located in plasma membrane. Predicted to be active in nucleolus. Is expressed in embryo. Orthologous to human DDX50 (DExD-box helicase 50). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E11.5 (RPKM 26.0), bladder adult (RPKM 19.0) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B4; 10 32.44 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (62451571..62487260, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (62615792..62658764, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236366

d4rat71 (e-PCR)
- UniSTS:122035

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H2AZ histone chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H3-H4 histone complex chaperone activity	IEA Inferred from Electronic Annotation more info
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables chromatin extrusion motor activity	IEA Inferred from Electronic Annotation more info
enables cohesin loader activity	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chromatin looping	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ATP-dependent RNA helicase DDX50

Names: DEAD (Asp-Glu-Ala-Asp) box polypeptide 50; DEAD box protein 50; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 50; RH-II/Gubeta; gu-beta; nucleolar protein GU2

NP_001345748.1

EC 3.6.4.13

NP_001345749.1

EC 3.6.4.13

NP_444413.1

EC 3.6.4.13

XP_006514408.1

EC 3.6.4.13

XP_011241910.1

EC 3.6.4.13

XP_030101267.1

EC 3.6.4.13

XP_030101268.1

EC 3.6.4.13

XP_030101269.1

EC 3.6.4.13

XP_030101270.1

EC 3.6.4.13

XP_036012018.1

EC 3.6.4.13

XP_036012019.1

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001358819.1 → NP_001345748.1 ATP-dependent RNA helicase DDX50 isoform 2

Status: VALIDATED

Source sequence(s)

AC121961, AK041281, AK162423

UniProtKB/TrEMBL

Q5BKP5, Q8BRU5

Conserved Domains (3) summary

COG0513
Location:65 → 543

SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

cd12936
Location:500 → 591

GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins

cd17944
Location:80 → 281

DEADc_DDX21_DDX50; DEAD-box helicase domain of DEAD box proteins 21 and 50
NM_001358820.1 → NP_001345749.1 ATP-dependent RNA helicase DDX50 isoform 2

Status: VALIDATED

Source sequence(s)

AK030239, AK041281, CF898436

UniProtKB/TrEMBL

Q5BKP5, Q8BRU5

Related

ENSMUST00000218372.2

Conserved Domains (3) summary

COG0513
Location:65 → 543

SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

cd12936
Location:500 → 591

GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins

cd17944
Location:80 → 281

DEADc_DDX21_DDX50; DEAD-box helicase domain of DEAD box proteins 21 and 50
NM_053183.3 → NP_444413.1 ATP-dependent RNA helicase DDX50 isoform 1

See identical proteins and their annotated locations for NP_444413.1

Status: VALIDATED

Source sequence(s)

AC121961, AK041281, AK162423

Consensus CDS

CCDS23892.1

UniProtKB/Swiss-Prot

Q99MJ9

UniProtKB/TrEMBL

Q5BKP5

Related

ENSMUSP00000020270.5, ENSMUST00000020270.6

Conserved Domains (4) summary

COG0513
Location:130 → 608

SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

cd00079
Location:369 → 486

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

cd00268
Location:136 → 339

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

cd12936
Location:565 → 656

GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

62451571..62487260 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006514345.5 → XP_006514408.1 ATP-dependent RNA helicase DDX50 isoform X1

UniProtKB/TrEMBL

Q5BKP5

Conserved Domains (3) summary

COG0513
Location:130 → 554

SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

cd12936
Location:511 → 602

GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins

cd17944
Location:145 → 346

DEADc_DDX21_DDX50; DEAD-box helicase domain of DEAD box proteins 21 and 50
XM_030245409.2 → XP_030101269.1 ATP-dependent RNA helicase DDX50 isoform X3

Conserved Domains (3) summary

COG0513
Location:65 → 489

SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

cd12936
Location:446 → 537

GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins

cd17944
Location:80 → 281

DEADc_DDX21_DDX50; DEAD-box helicase domain of DEAD box proteins 21 and 50
XM_011243608.4 → XP_011241910.1 ATP-dependent RNA helicase DDX50 isoform X4

Conserved Domains (2) summary

COG0513
Location:1 → 317

SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

cd12936
Location:274 → 365

GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins
XM_030245410.2 → XP_030101270.1 ATP-dependent RNA helicase DDX50 isoform X4

Conserved Domains (2) summary

COG0513
Location:1 → 317

SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

cd12936
Location:274 → 365

GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins
XM_036156125.1 → XP_036012018.1 ATP-dependent RNA helicase DDX50 isoform X4

Conserved Domains (2) summary

COG0513
Location:1 → 317

SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

cd12936
Location:274 → 365

GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins
XM_036156126.1 → XP_036012019.1 ATP-dependent RNA helicase DDX50 isoform X5

Conserved Domains (3) summary

COG0513
Location:1 → 263

SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

cd12936
Location:220 → 311

GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins

cl28899
Location:1 → 55

DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
XM_030245408.2 → XP_030101268.1 ATP-dependent RNA helicase DDX50 isoform X2

UniProtKB/TrEMBL

Q5BKP5, Q8BRU5

Conserved Domains (3) summary

COG0513
Location:65 → 543

SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

cd12936
Location:500 → 591

GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins

cd17944
Location:80 → 281

DEADc_DDX21_DDX50; DEAD-box helicase domain of DEAD box proteins 21 and 50
XM_030245407.2 → XP_030101267.1 ATP-dependent RNA helicase DDX50 isoform X2

UniProtKB/TrEMBL

Q5BKP5, Q8BRU5

Conserved Domains (3) summary

COG0513
Location:65 → 543

SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

cd12936
Location:500 → 591

GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins

cd17944
Location:80 → 281

DEADc_DDX21_DDX50; DEAD-box helicase domain of DEAD box proteins 21 and 50