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    Mst1r macrophage stimulating 1 receptor (c-met-related tyrosine kinase) [ Mus musculus (house mouse) ]

    Gene ID: 19882, updated on 3-Dec-2024

    Summary

    Official Symbol
    Mst1rprovided by MGI
    Official Full Name
    macrophage stimulating 1 receptor (c-met-related tyrosine kinase)provided by MGI
    Primary source
    MGI:MGI:99614
    See related
    Ensembl:ENSMUSG00000032584 AllianceGenome:MGI:99614
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fv2; Ron; STK; Fv-2; PTK8; CD136; CDw136; p185-Ron
    Summary
    This gene encodes a precursor protein that is proteolytically cleaved to yield an alpha chain and a beta chain which form a membrane-spanning heterodimer. The encoded protein belongs to a family of cell-surface receptor tyrosine kinases involved in signaling from the cell surface to the intracellular environment. The binding of the encoded protein to its ligand, macrophage-stimulating protein, mediates several biological activities including wound healing, tumor immunity, macrophage activation and hematopoiesis as well as cell growth, motility, survival and adhesion. The protein encoded by this gene also functions in early development and the macrophage-mediated inflammatory response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
    Expression
    Biased expression in stomach adult (RPKM 26.6), colon adult (RPKM 26.4) and 12 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Mst1r in Genome Data Viewer
    Location:
    9 59.07 cM; 9 F1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (107784057..107797582)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (107906858..107920383)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene MON1 homolog A, secretory traffciking associated Neighboring gene predicted gene, 23856 Neighboring gene actin-like 11 Neighboring gene CaM kinase-like vesicle-associated

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GPI-linked ephrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables boss receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables brain-derived neurotrophic factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables epidermal growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables fibroblast growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hepatocyte growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables insulin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables insulin-like growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables macrophage colony-stimulating factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables placental growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables platelet-derived growth factor alpha-receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables platelet-derived growth factor beta-receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine kinase collagen receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables stem cell factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transmembrane-ephrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables vascular endothelial growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in Kit signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in brain-derived neurotrophic factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in collagen-activated tyrosine kinase receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ephrin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epidermal growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hepatocyte growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in insulin-like growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in macrophage colony-stimulating factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phagocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in platelet-derived growth factor receptor-alpha signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in platelet-derived growth factor receptor-beta signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vascular endothelial growth factor receptor-1 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vascular endothelial growth factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in stress fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in vacuole IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    macrophage-stimulating protein receptor
    Names
    MSP receptor
    friend virus susceptibility 2
    receptor protein tyrosine kinase, c-met-related
    stem cell-derived tyrosine kinase
    NP_001274190.1
    NP_001400491.1
    NP_033100.2
    XP_006511717.1
    XP_006511718.1
    XP_006511721.1
    XP_017168707.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001287261.2NP_001274190.1  macrophage-stimulating protein receptor isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL731808
      Conserved Domains (1) summary
      cl21453
      Location:162423
      PKc_like; Protein Kinases, catalytic domain
    2. NM_001413562.1NP_001400491.1  macrophage-stimulating protein receptor isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL731808
      UniProtKB/TrEMBL
      B2RUR6
    3. NM_009074.3NP_033100.2  macrophage-stimulating protein receptor isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_033100.2

      Status: VALIDATED

      Source sequence(s)
      AL731808
      Consensus CDS
      CCDS23509.1
      UniProtKB/Swiss-Prot
      E9QMZ4, Q62190, Q62555
      UniProtKB/TrEMBL
      B2RUR6
      Related
      ENSMUSP00000035203.8, ENSMUST00000035203.9
      Conserved Domains (7) summary
      cd11279
      Location:29525
      Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase
      smart00429
      Location:771863
      IPT; ig-like, plexins, transcription factors
      cd01179
      Location:686770
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd05058
      Location:10631324
      PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
      pfam01437
      Location:528567
      PSI; Plexin repeat
      pfam07714
      Location:10591315
      Pkinase_Tyr; Protein tyrosine kinase
      cl15674
      Location:571685
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

    RNA

    1. NR_109782.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL731808
      Related
      ENSMUST00000195617.6

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      107784057..107797582
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511654.4XP_006511717.1  macrophage-stimulating protein receptor isoform X1

      UniProtKB/TrEMBL
      B2RUR6
      Conserved Domains (6) summary
      cd11279
      Location:29525
      Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase
      smart00423
      Location:528570
      PSI; domain found in Plexins, Semaphorins and Integrins
      smart00429
      Location:771864
      IPT; ig-like, plexins, transcription factors
      cd01179
      Location:686770
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cl15674
      Location:571685
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
      cl21453
      Location:10641352
      PKc_like; Protein Kinases, catalytic domain
    2. XM_006511655.4XP_006511718.1  macrophage-stimulating protein receptor isoform X2

      UniProtKB/TrEMBL
      B2RUR6
      Conserved Domains (6) summary
      cd11279
      Location:29525
      Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase
      smart00423
      Location:528570
      PSI; domain found in Plexins, Semaphorins and Integrins
      smart00429
      Location:771863
      IPT; ig-like, plexins, transcription factors
      cd01179
      Location:686770
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cl15674
      Location:571685
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
      cl21453
      Location:10631351
      PKc_like; Protein Kinases, catalytic domain
    3. XM_006511658.3XP_006511721.1  macrophage-stimulating protein receptor isoform X5

      Conserved Domains (3) summary
      cd11279
      Location:29525
      Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase
      smart00423
      Location:528570
      PSI; domain found in Plexins, Semaphorins and Integrins
      cl15674
      Location:571685
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
    4. XM_017313218.1XP_017168707.1  macrophage-stimulating protein receptor isoform X4

      Conserved Domains (6) summary
      smart00423
      Location:99141
      PSI; domain found in Plexins, Semaphorins and Integrins
      smart00429
      Location:342435
      IPT; ig-like, plexins, transcription factors
      cd01179
      Location:257341
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cl15674
      Location:142256
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
      cl15693
      Location:196
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
      cl21453
      Location:635923
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_379757.5 RNA Sequence

    2. XR_379756.5 RNA Sequence