Dkk1 dickkopf WNT signaling pathway inhibitor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dkk1provided by MGI
Official Full Name: dickkopf WNT signaling pathway inhibitor 1provided by MGI
Primary source: MGI:MGI:1329040
See related: Ensembl:ENSMUSG00000024868 AllianceGenome:MGI:1329040
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mdkk-1
Summary: Predicted to enable co-receptor binding activity; low-density lipoprotein particle receptor binding activity; and receptor antagonist activity. Involved in several processes, including motor learning; negative regulation of cellular component organization; and regulation of gene expression. Acts upstream of or within several processes, including Wnt signaling pathway involved in somitogenesis; embryonic morphogenesis; and negative regulation of signal transduction. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; embryo mesenchyme; eye; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in anodontia. Orthologous to human DKK1 (dickkopf WNT signaling pathway inhibitor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in limb E14.5 (RPKM 5.1), placenta adult (RPKM 1.6) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C1; 19 25.16 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (30523276..30526896, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (30545876..30549496, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SIRT2-dependent DKK1 deacetylation aggravates polycystic ovary syndrome by targeting the TGF-beta1/Smad3 signaling pathway.
Title: SIRT2-dependent DKK1 deacetylation aggravates polycystic ovary syndrome by targeting the TGF-β1/Smad3 signaling pathway.
DKK1 loss promotes endometrial fibrosis via autophagy and exosome-mediated macrophage-to-myofibroblast transition.
Title: DKK1 loss promotes endometrial fibrosis via autophagy and exosome-mediated macrophage-to-myofibroblast transition.
Dickkopf-1 (DKK1) blockade mitigates osteogenesis imperfecta (OI) related bone disease.
Title: Dickkopf-1 (DKK1) blockade mitigates osteogenesis imperfecta (OI) related bone disease.
Involvement of DKK1 secreted from adipose-derived stem cells in alopecia areata.
Title: Involvement of DKK1 secreted from adipose-derived stem cells in alopecia areata.
DKK-1 and Its Influences on Bone Destruction: A Comparative Study in Collagen-Induced Arthritis Mice and Rheumatoid Arthritis Patients.
Title: DKK-1 and Its Influences on Bone Destruction: A Comparative Study in Collagen-Induced Arthritis Mice and Rheumatoid Arthritis Patients.
Fibroblasts inhibit osteogenesis by regulating nuclear-cytoplasmic shuttling of YAP in mesenchymal stem cells and secreting DKK1.
Title: Fibroblasts inhibit osteogenesis by regulating nuclear-cytoplasmic shuttling of YAP in mesenchymal stem cells and secreting DKK1.
Thrombocyte-derived Dickkopf1 promotes macrophage polarization in the Bleomycin-induced lung injury model.
Title: Thrombocyte-derived Dickkopf1 promotes macrophage polarization in the Bleomycin-induced lung injury model.
Promotion of hepatic stellate cell activation and liver fibrosis by microRNA-33a-5p through targeting the Dickkopf-1-mediated wingless-related integration site/beta-catenin pathway.
Title: Promotion of hepatic stellate cell activation and liver fibrosis by microRNA-33a-5p through targeting the Dickkopf-1-mediated wingless-related integration site/beta-catenin pathway.
Dkk-1-TNF-alpha crosstalk regulates MC3T3E1 pre-osteoblast proliferation and differentiation under mechanical stress through the ERK signaling pathway.
Title: Dkk-1-TNF-α crosstalk regulates MC3T3E1 pre-osteoblast proliferation and differentiation under mechanical stress through the ERK signaling pathway.
Dickkopf1 Promotes Pulmonary Fibrosis upon Bleomycin-Induced Lung Injury.
Title: Dickkopf1 Promotes Pulmonary Fibrosis upon Bleomycin-Induced Lung Injury.

Submit: New GeneRIF Correction See all GeneRIFs (136)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Targeted (11) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dkk1 (e-PCR), detects polymorphism
- UniSTS:471821

Dkk1 (e-PCR), detects polymorphism
- UniSTS:508429

Dkk1 (e-PCR), detects polymorphism
- UniSTS:508430

UniSTS:498746 (e-PCR)
- UniSTS:498746

Dkk1 (e-PCR), detects polymorphism
- UniSTS:498746

Dkk1 (e-PCR), detects polymorphism
- UniSTS:472901

Dkk1 (e-PCR), detects polymorphism
- UniSTS:277877

NoName (e-PCR)
- UniSTS:548469

Dkk1 (e-PCR), detects polymorphism
- UniSTS:516472

Dkk1 (e-PCR), detects polymorphism
- UniSTS:506847

UniSTS:498426 (e-PCR)
- UniSTS:498426

Dkk1 (e-PCR), detects polymorphism
- UniSTS:498426

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables co-receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables co-receptor binding	IEA Inferred from Electronic Annotation more info
enables co-receptor binding	ISO Inferred from Sequence Orthology more info
enables low-density lipoprotein particle receptor binding	ISO Inferred from Sequence Orthology more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor antagonist activity	IBA Inferred from Biological aspect of Ancestor more info
enables receptor antagonist activity	IEA Inferred from Electronic Annotation more info
enables receptor antagonist activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within Wnt signaling pathway involved in somitogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic limb morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within endoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endoderm formation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within face morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within forebrain development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hair follicle development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within head morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in heart induction	IDA Inferred from Direct Assay more info	PubMed
involved_in learning or memory	IDA Inferred from Direct Assay more info	PubMed
involved_in limb development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mesoderm formation	IDA Inferred from Direct Assay more info	PubMed
involved_in motor learning	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of SMAD protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Wnt-Frizzled-LRP5/6 complex assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Wnt-Frizzled-LRP5/6 complex assembly	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cardiac muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cardiac muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mesodermal cell fate specification	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mesodermal cell fate specification	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of ossification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of ossification	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of presynapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein binding	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of midbrain dopaminergic neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of endodermal cell fate specification	IEA Inferred from Electronic Annotation more info
involved_in regulation of endodermal cell fate specification	ISO Inferred from Sequence Orthology more info
involved_in regulation of receptor internalization	IEA Inferred from Electronic Annotation more info
involved_in regulation of receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in regulation of synapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic transmission, glutamatergic	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to retinoic acid	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: dickkopf-related protein 1

Names: dickkopf homolog 1; dickkopf-1; dickkopf-like protein 1; dkk-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.