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    RPS23A ribosomal 40S subunit protein S23A [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853015, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RPS23A
    Official Full Name
    ribosomal 40S subunit protein S23A
    Primary source
    SGD:S000003350
    Locus tag
    YGR118W
    See related
    AllianceGenome:SGD:S000003350; FungiDB:YGR118W; VEuPathDB:YGR118W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    A structural constituent of ribosome. Involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and regulation of translational fidelity. Part of cytosolic small ribosomal subunit. Human ortholog(s) of this gene implicated in brachycephaly, trichomegaly, and developmental delay. Orthologous to human RPS23 (ribosomal protein S23). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RPS23A in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    2
    Sequence:
    Chromosome: VII; NC_001139.9 (726974..727730)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene chromatin-remodeling histone chaperone SPT6 Neighboring gene uncharacterized protein Neighboring gene FG-nucleoporin NUP57 Neighboring gene Golgi transport complex subunit COG2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The sequence of a 23.4 kb segment on the right arm of chromosome VII from Saccharomyces cerevisiae reveals CLB6, SPT6, RP28A and NUP57 genes, a Ty3 element and 11 new open reading frames. Hansen M, et al. Yeast, 1996 Sep 30. PMID 8905931
    2. A novel cloning strategy reveals the gene for the yeast homologue to Escherichia coli ribosomal protein S12. Alksne LE, et al. J Biol Chem, 1993 May 25. PMID 8496146
    3. An accuracy center in the ribosome conserved over 2 billion years. Alksne LE, et al. Proc Natl Acad Sci U S A, 1993 Oct 15. PMID 8415737, Free PMC Article
    4. Mutations in yeast ribosomal proteins S28 and S4 affect the accuracy of translation and alter the sensitivity of the ribosomes to paromomycin. Synetos D, et al. Biochim Biophys Acta, 1996 Nov 11. PMID 8950190
    5. Structural insights into ribosomal rescue by Dom34 and Hbs1 at near-atomic resolution. Hilal T, et al. Nat Commun, 2016 Dec 20. PMID 27995908, Free PMC Article

    See all (91) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of translational fidelity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of translational fidelity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic small ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small ribosomal subunit IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal 40S subunit protein S23A
    NP_011633.3
    • Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit; required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23A has a paralog, RPS23B, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      726974..727730
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181247.3 → NP_011633.3  TPA: ribosomal 40S subunit protein S23A [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011633.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUP9, P0CX29, P0CX30, P32827
      UniProtKB/TrEMBL
      A6ZUD1, B3LIB1, C8Z909, C8ZJF4, G2WEK0, N1P5W3
      Conserved Domains (1) summary
      PTZ00067
      Location:4 → 145
      PTZ00067; 40S ribosomal S23; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CX29.1
    P0CX30.1

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