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    DYN3 dynein light intermediate chain [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855345, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DYN3
    Official Full Name
    dynein light intermediate chain
    Primary source
    SGD:S000004914
    Locus tag
    YMR299C
    See related
    AllianceGenome:SGD:S000004914; FungiDB:YMR299C; VEuPathDB:YMR299C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to cytoskeletal motor activity. Involved in nuclear migration along microtubule. Located in cytoplasmic microtubule. Part of cytoplasmic dynein complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See DYN3 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (864412..865350, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene carboxypeptidase C PRC1 Neighboring gene sphingosine N-acyltransferase subunit LIP1 Neighboring gene amidophosphoribosyltransferase Neighboring gene ATP-binding cassette Fe/S cluster precursor transporter ATM1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cytoplasmic dynein moves through uncoordinated stepping of the AAA+ ring domains. DeWitt MA, et al. Science, 2012 Jan 13. PMID 22157083, Free PMC Article
    2. The offloading model for dynein function: differential function of motor subunits. Lee WL, et al. J Cell Biol, 2005 Jan 17. PMID 15642746, Free PMC Article
    3. Dynein achieves processive motion using both stochastic and coordinated stepping. Qiu W, et al. Nat Struct Mol Biol, 2012 Jan 8. PMID 22231401, Free PMC Article
    4. Regulated offloading of cytoplasmic dynein from microtubule plus ends to the cortex. Markus SM, et al. Dev Cell, 2011 May 17. PMID 21571221, Free PMC Article
    5. Pac1/LIS1 stabilizes an uninhibited conformation of dynein to coordinate its localization and activity. Marzo MG, et al. Nat Cell Biol, 2020 May. PMID 32341548, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LIC/Dyn3 has a role in dynein function which providing new insight into the offloading model.
      Title: The offloading model for dynein function: differential function of motor subunits.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to cytoskeletal motor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nuclear migration along microtubule IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytoplasmic dynein complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasmic microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dynein light intermediate chain
    NP_014028.2
    • Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      864412..865350 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182808.2 → NP_014028.2  TPA: dynein light intermediate chain [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014028.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0C6, Q03592, Q04949
      UniProtKB/TrEMBL
      A6ZN15, B3LMI7, B5VQ65, C7GTK0, C8ZFG8, G2WL08
      Conserved Domains (1) summary
      pfam05783
      Location:163 → 301
      DLIC; Dynein light intermediate chain (DLIC)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04949.2

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