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    SLC4A7 solute carrier family 4 member 7 [ Homo sapiens (human) ]

    Gene ID: 9497, updated on 10-Dec-2024

    Summary

    Official Symbol
    SLC4A7provided by HGNC
    Official Full Name
    solute carrier family 4 member 7provided by HGNC
    Primary source
    HGNC:HGNC:11033
    See related
    Ensembl:ENSG00000033867 MIM:603353; AllianceGenome:HGNC:11033
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NBC2; NBC3; SBC2; NBCN1; SLC4A6
    Summary
    This locus encodes a sodium bicarbonate cotransporter. The encoded transmembrane protein appears to transport sodium and bicarbonate ions in a 1:1 ratio, and is thus considered an electroneutral cotransporter. The encoded protein likely plays a critical role in regulation of intracellular pH involved in visual and auditory sensory transmission. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Apr 2012]
    Expression
    Ubiquitous expression in duodenum (RPKM 27.5), small intestine (RPKM 8.8) and 20 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SLC4A7 in Genome Data Viewer
    Location:
    3p24.1
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (27372723..27484384, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (27374872..27486481, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (27414214..27525875, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene NIMA related kinase 10 Neighboring gene MICOS10 pseudogene 3 Neighboring gene MPRA-validated peak4579 silencer Neighboring gene RNA, U6 small nuclear 342, pseudogene Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:27352339-27353538 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:27410132-27410632 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:27483819-27484320 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:27505552-27506411 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:27513115-27513615 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19616 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19617 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19618 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:27525149-27525925 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19619 Neighboring gene ribosomal protein S20 pseudogene 15 Neighboring gene uncharacterized LOC105377005 Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene 4 Neighboring gene RNA, U1 small nuclear 96, pseudogene

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age.
    EBI GWAS Catalog
    Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
    EBI GWAS Catalog
    Genome-wide association study identifies five new breast cancer susceptibility loci.
    EBI GWAS Catalog
    Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
    EBI GWAS Catalog
    Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.
    EBI GWAS Catalog
    Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
    EBI GWAS Catalog
    Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of SLC4A7 PubMed
    Knockdown of solute carrier family 4, sodium bicarbonate cotransporter, member 7 (SLC4A7) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp686H168

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables monoatomic anion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sodium:bicarbonate symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sodium:bicarbonate symporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sodium:bicarbonate symporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables sodium:bicarbonate symporter activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables sodium:bicarbonate symporter activity TAS
    Traceable Author Statement
    more info
     
    enables solute:inorganic anion antiporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in auditory receptor cell development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in bicarbonate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in bicarbonate transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in bicarbonate transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in bicarbonate transport TAS
    Traceable Author Statement
    more info
     
    involved_in cellular response to growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in inorganic anion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in monoatomic anion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phagosome acidification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in purine nucleotide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in pyrimidine nucleotide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of intracellular pH IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in stereocilium IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    sodium bicarbonate cotransporter 3
    Names
    bicarbonate transporter
    electroneutral Na/HCO(3) cotransporter
    sodium bicarbonate cotransporter 2
    sodium bicarbonate cotransporter 2b
    solute carrier family 4, sodium bicarbonate cotransporter, member 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032673.1 RefSeqGene

      Range
      5037..116698
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258379.2NP_001245308.1  sodium bicarbonate cotransporter 3 isoform b

      See identical proteins and their annotated locations for NP_001245308.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This variant has additional differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AA569234, AK310865, AL389947, CR627428, DA756057, EU499349, EU934246
      Consensus CDS
      CCDS58820.1
      UniProtKB/TrEMBL
      B5M450
      Related
      ENSP00000407382.1, ENST00000455077.5
      Conserved Domains (1) summary
      cl26877
      Location:1181016
      Band_3_cyto; Band 3 cytoplasmic domain
    2. NM_001258380.2NP_001245309.1  sodium bicarbonate cotransporter 3 isoform c

      See identical proteins and their annotated locations for NP_001245309.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform c), compared to isoform a.
      Source sequence(s)
      AA569234, AC099535, AF089726, AK310865, AL389947, EU934250
      Consensus CDS
      CCDS58819.1
      UniProtKB/TrEMBL
      C9JRP1
      Related
      ENSP00000416368.1, ENST00000428386.5
      Conserved Domains (3) summary
      TIGR00834
      Location:1131011
      ae; anion exchange protein
      pfam00955
      Location:451964
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:141408
      Band_3_cyto; Band 3 cytoplasmic domain
    3. NM_001321103.2NP_001308032.1  sodium bicarbonate cotransporter 3 isoform d

      Status: REVIEWED

      Source sequence(s)
      AA569234, AF047033, AF053755, AK309734, AK310865, AL389947, EU499349, EU934248, EU934249, FJ178574
      Consensus CDS
      CCDS82747.1
      UniProtKB/TrEMBL
      B5M450
      Related
      ENSP00000390394.1, ENST00000454389.6
      Conserved Domains (3) summary
      TIGR00834
      Location:1221144
      ae; anion exchange protein
      pfam00955
      Location:5841097
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:150541
      Band_3_cyto; Band 3 cytoplasmic domain
    4. NM_001321104.2NP_001308033.1  sodium bicarbonate cotransporter 3 isoform e

      Status: REVIEWED

      Source sequence(s)
      AA569234, AF047033, AF053755, AK309734, AK310865, AL389947, EU934250
      Consensus CDS
      CCDS82749.1
      UniProtKB/TrEMBL
      B5M450
      Related
      ENSP00000414797.1, ENST00000440156.5
      Conserved Domains (3) summary
      TIGR00834
      Location:1221131
      ae; anion exchange protein
      pfam00955
      Location:5711084
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:150528
      Band_3_cyto; Band 3 cytoplasmic domain
    5. NM_001321105.2NP_001308034.1  sodium bicarbonate cotransporter 3 isoform f

      Status: REVIEWED

      Source sequence(s)
      AA569234, AF047033, AF053755, AK309734, AK310865, AL389947, EU499349, EU934247, EU934249, FJ178574
      Consensus CDS
      CCDS82748.1
      UniProtKB/TrEMBL
      B5M450, E9PFN4
      Related
      ENSP00000406804.1, ENST00000445684.5
      Conserved Domains (3) summary
      TIGR00834
      Location:1221131
      ae; anion exchange protein
      pfam00955
      Location:5711084
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:150528
      Band_3_cyto; Band 3 cytoplasmic domain
    6. NM_001321106.2NP_001308035.1  sodium bicarbonate cotransporter 3 isoform g

      Status: REVIEWED

      Source sequence(s)
      AA569234, AF047033, AF053755, AK309734, AK310865, AL389947, EU499349, EU934249, FJ178574
      Consensus CDS
      CCDS82751.1
      UniProtKB/TrEMBL
      B5M450
      Related
      ENSP00000406605.1, ENST00000446700.5
      Conserved Domains (3) summary
      TIGR00834
      Location:1181127
      ae; anion exchange protein
      pfam00955
      Location:5671080
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:146524
      Band_3_cyto; Band 3 cytoplasmic domain
    7. NM_001321107.2NP_001308036.1  sodium bicarbonate cotransporter 3 isoform h

      Status: REVIEWED

      Source sequence(s)
      AA569234, AF047033, AF053755, AK309734, AK310865, AL389947, EU499349, EU934249
      Consensus CDS
      CCDS82750.1
      UniProtKB/TrEMBL
      B5M450
      Related
      ENSP00000394252.1, ENST00000437179.5
      Conserved Domains (3) summary
      TIGR00834
      Location:1181016
      ae; anion exchange protein
      pfam00955
      Location:456969
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:146413
      Band_3_cyto; Band 3 cytoplasmic domain
    8. NM_001321108.2NP_001308037.1  sodium bicarbonate cotransporter 3 isoform i

      Status: REVIEWED

      Source sequence(s)
      AA569234, AF047033, AF053755, AK309734, AK310865, AL389947, EU499349, EU934249, GU354308
      UniProtKB/TrEMBL
      B5M450
      Conserved Domains (3) summary
      TIGR00834
      Location:1221020
      ae; anion exchange protein
      pfam00955
      Location:460973
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:150417
      Band_3_cyto; Band 3 cytoplasmic domain
    9. NM_003615.5NP_003606.3  sodium bicarbonate cotransporter 3 isoform a

      See identical proteins and their annotated locations for NP_003606.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant encodes isoform a.
      Source sequence(s)
      AA569234, AC099535, AF047033, AK310865, AL389947, EU934250
      Consensus CDS
      CCDS33721.1
      UniProtKB/Swiss-Prot
      A6NIA8, B2CI53, B5M449, B5M451, B5M452, B5M453, B6DY52, B6DY53, C9JST9, D3K174, D3K175, O60350, Q6AHZ9, Q9HC88, Q9UIB9, Q9Y6M7
      UniProtKB/TrEMBL
      B5M450
      Related
      ENSP00000295736.5, ENST00000295736.9
      Conserved Domains (3) summary
      TIGR00834
      Location:1131135
      ae; anion exchange protein
      pfam00955
      Location:5751088
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:141532
      Band_3_cyto; Band 3 cytoplasmic domain

    RNA

    1. NR_135541.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AA569234, AF047033, AF053755, AK309734, AK310865, AL389947, FJ178574
    2. NR_135542.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AA569234, AF047033, AF053755, AK309734, AK310865, AL389947, FJ178574, FJ178575
    3. NR_135543.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AA569234, AF047033, AF053755, AK309734, AK310865, AL389947, FJ178574, FJ178575
    4. NR_135544.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AA569234, AF047033, AF053755, AK309734, AK310865, AL389947, EU499349, EU934249, FJ178574, GU354307

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      27372723..27484384 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017007527.3XP_016863016.1  sodium bicarbonate cotransporter 3 isoform X9

      UniProtKB/TrEMBL
      B5M450
    2. XM_047449246.1XP_047305202.1  sodium bicarbonate cotransporter 3 isoform X3

      UniProtKB/TrEMBL
      B5M450
    3. XM_006713421.4XP_006713484.1  sodium bicarbonate cotransporter 3 isoform X1

      UniProtKB/TrEMBL
      B5M450
      Conserved Domains (3) summary
      TIGR00834
      Location:1181140
      ae; anion exchange protein
      pfam00955
      Location:5801093
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:146537
      Band_3_cyto; Band 3 cytoplasmic domain
    4. XM_011534263.4XP_011532565.1  sodium bicarbonate cotransporter 3 isoform X8

      UniProtKB/TrEMBL
      B5M450
      Conserved Domains (3) summary
      TIGR00834
      Location:1221007
      ae; anion exchange protein
      pfam00955
      Location:447960
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:150404
      Band_3_cyto; Band 3 cytoplasmic domain
    5. XM_011534265.3XP_011532567.1  sodium bicarbonate cotransporter 3 isoform X11

      UniProtKB/TrEMBL
      B5M450
      Conserved Domains (3) summary
      TIGR00834
      Location:1221020
      ae; anion exchange protein
      pfam00955
      Location:460973
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:150417
      Band_3_cyto; Band 3 cytoplasmic domain
    6. XM_011534258.3XP_011532560.1  sodium bicarbonate cotransporter 3 isoform X4

      UniProtKB/TrEMBL
      B5M450
      Conserved Domains (3) summary
      TIGR00834
      Location:1221144
      ae; anion exchange protein
      pfam00955
      Location:5841097
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:150541
      Band_3_cyto; Band 3 cytoplasmic domain
    7. XM_047449247.1XP_047305203.1  sodium bicarbonate cotransporter 3 isoform X6

      UniProtKB/TrEMBL
      B5M450
    8. XM_005265600.6XP_005265657.1  sodium bicarbonate cotransporter 3 isoform X10

      UniProtKB/TrEMBL
      C9JRP1
      Conserved Domains (3) summary
      TIGR00834
      Location:113998
      ae; anion exchange protein
      pfam00955
      Location:438951
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:141395
      Band_3_cyto; Band 3 cytoplasmic domain
    9. XM_011534261.4XP_011532563.1  sodium bicarbonate cotransporter 3 isoform X5

      UniProtKB/TrEMBL
      B5M450
      Conserved Domains (3) summary
      TIGR00834
      Location:1131122
      ae; anion exchange protein
      pfam00955
      Location:5621075
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:141519
      Band_3_cyto; Band 3 cytoplasmic domain
    10. XM_005265598.6XP_005265655.1  sodium bicarbonate cotransporter 3 isoform X7

      UniProtKB/TrEMBL
      C9JRP1
      Conserved Domains (3) summary
      TIGR00834
      Location:1131011
      ae; anion exchange protein
      pfam00955
      Location:451964
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:141408
      Band_3_cyto; Band 3 cytoplasmic domain
    11. XM_011534256.4XP_011532558.1  sodium bicarbonate cotransporter 3 isoform X2

      UniProtKB/TrEMBL
      B5M450
      Conserved Domains (3) summary
      TIGR00834
      Location:1131135
      ae; anion exchange protein
      pfam00955
      Location:5751088
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:141532
      Band_3_cyto; Band 3 cytoplasmic domain
    12. XM_017007529.1XP_016863018.1  sodium bicarbonate cotransporter 3 isoform X12

      UniProtKB/TrEMBL
      H7C3C4
      Related
      ENSP00000411031.1, ENST00000419036.5
    13. XM_017007528.1XP_016863017.1  sodium bicarbonate cotransporter 3 isoform X12

      UniProtKB/TrEMBL
      H7C3C4
    14. XM_047449248.1XP_047305204.1  sodium bicarbonate cotransporter 3 isoform X13

      Related
      ENSP00000409418.1, ENST00000437266.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      27374872..27486481 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348464.1XP_054204439.1  sodium bicarbonate cotransporter 3 isoform X9

      UniProtKB/TrEMBL
      B5M450
    2. XM_054348458.1XP_054204433.1  sodium bicarbonate cotransporter 3 isoform X3

      UniProtKB/TrEMBL
      B5M450
    3. XM_054348456.1XP_054204431.1  sodium bicarbonate cotransporter 3 isoform X1

      UniProtKB/TrEMBL
      B5M450
    4. XM_054348463.1XP_054204438.1  sodium bicarbonate cotransporter 3 isoform X8

      UniProtKB/TrEMBL
      B5M450
    5. XM_054348466.1XP_054204441.1  sodium bicarbonate cotransporter 3 isoform X11

      UniProtKB/TrEMBL
      B5M450
    6. XM_054348459.1XP_054204434.1  sodium bicarbonate cotransporter 3 isoform X4

      UniProtKB/TrEMBL
      B5M450
    7. XM_054348461.1XP_054204436.1  sodium bicarbonate cotransporter 3 isoform X6

      UniProtKB/TrEMBL
      B5M450
    8. XM_054348465.1XP_054204440.1  sodium bicarbonate cotransporter 3 isoform X10

      UniProtKB/TrEMBL
      C9JRP1
    9. XM_054348460.1XP_054204435.1  sodium bicarbonate cotransporter 3 isoform X5

      UniProtKB/TrEMBL
      B5M450
    10. XM_054348462.1XP_054204437.1  sodium bicarbonate cotransporter 3 isoform X7

      UniProtKB/TrEMBL
      C9JRP1
    11. XM_054348457.1XP_054204432.1  sodium bicarbonate cotransporter 3 isoform X2

      UniProtKB/TrEMBL
      B5M450
    12. XM_054348468.1XP_054204443.1  sodium bicarbonate cotransporter 3 isoform X12

      UniProtKB/TrEMBL
      H7C3C4
    13. XM_054348467.1XP_054204442.1  sodium bicarbonate cotransporter 3 isoform X12

      UniProtKB/TrEMBL
      H7C3C4
    14. XM_054348469.1XP_054204444.1  sodium bicarbonate cotransporter 3 isoform X13