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    RMDN1 regulator of microtubule dynamics 1 [ Homo sapiens (human) ]

    Gene ID: 51115, updated on 9-Dec-2024

    Summary

    Official Symbol
    RMDN1provided by HGNC
    Official Full Name
    regulator of microtubule dynamics 1provided by HGNC
    Primary source
    HGNC:HGNC:24285
    See related
    Ensembl:ENSG00000176623 MIM:611871; AllianceGenome:HGNC:24285
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RMD1; RMD-1; CGI-90; FAM82B
    Summary
    Enables microtubule binding activity. Predicted to be involved in attachment of mitotic spindle microtubules to kinetochore and mitotic spindle organization. Located in mitotic spindle pole and spindle microtubule. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 10.5), fat (RPKM 10.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RMDN1 in Genome Data Viewer
    Location:
    8q21.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (86468266..86514357, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (87588507..87634595, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (87484578..87526586, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 7 member 13 Neighboring gene HNF4 motif-containing MPRA enhancer 29 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19341 Neighboring gene WWP1 antisense RNA 1 Neighboring gene WW domain containing E3 ubiquitin protein ligase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27596 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19342 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19343 Neighboring gene N-terminal asparagine amidase pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27597 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27598 Neighboring gene solute carrier family 2 member 3 pseudogene 4 Neighboring gene copine 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:87604292-87604850 Neighboring gene cyclic nucleotide gated channel subunit beta 3 Neighboring gene myo-inositol oxygenase pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ20665

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in attachment of mitotic spindle microtubules to kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitotic spindle organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion HTP PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in mitotic spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitotic spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in spindle microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    regulator of microtubule dynamics protein 1
    Names
    family with sequence similarity 82, member B
    microtubule-associated protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286707.2NP_001273636.1  regulator of microtubule dynamics protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks and in-frame exon and uses and alternate in-frame splice site compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC103817, AK297896, BP234465, BX640636
      Consensus CDS
      CCDS69509.1
      UniProtKB/Swiss-Prot
      Q96DB5
      UniProtKB/TrEMBL
      Q6N086
      Related
      ENSP00000428661.1, ENST00000519966.5
    2. NM_001286719.2NP_001273648.1  regulator of microtubule dynamics protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the central coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AC103817, AK303122, BX640636
      Consensus CDS
      CCDS69510.1
      UniProtKB/Swiss-Prot
      Q96DB5
      UniProtKB/TrEMBL
      Q6N086
      Related
      ENSP00000409661.2, ENST00000430676.6
      Conserved Domains (1) summary
      sd00006
      Location:140169
      TPR; TPR repeat [structural motif]
    3. NM_001317807.2NP_001304736.1  regulator of microtubule dynamics protein 1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' and 3' UTRs, lacks a portion of the 5' coding region, uses a downstream translation start site, and uses two alternate splice sites in the 3' coding region, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC103817, AF151848, AL561197, BU932433, BX640636
      Consensus CDS
      CCDS83305.1
      UniProtKB/TrEMBL
      E5RH53, H0YB83
      Related
      ENSP00000429899.1, ENST00000523911.5
      Conserved Domains (1) summary
      sd00006
      Location:116156
      TPR; TPR repeat [structural motif]
    4. NM_016033.3NP_057117.2  regulator of microtubule dynamics protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC103817, AF151848, BP199284, BP234465
      Consensus CDS
      CCDS34918.1
      UniProtKB/Swiss-Prot
      A9UMZ8, B4DNF5, B4DZW6, B5MC61, C9JSC6, E7EVI2, Q96DB5, Q9Y398
      Related
      ENSP00000385927.3, ENST00000406452.8
      Conserved Domains (1) summary
      sd00006
      Location:164199
      TPR; TPR repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      86468266..86514357 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421832.1XP_047277788.1  regulator of microtubule dynamics protein 1 isoform X12

    2. XM_047421839.1XP_047277795.1  regulator of microtubule dynamics protein 1 isoform X29

    3. XM_047421830.1XP_047277786.1  regulator of microtubule dynamics protein 1 isoform X9

    4. XM_047421837.1XP_047277793.1  regulator of microtubule dynamics protein 1 isoform X24

    5. XM_047421829.1XP_047277785.1  regulator of microtubule dynamics protein 1 isoform X7

    6. XM_047421834.1XP_047277790.1  regulator of microtubule dynamics protein 1 isoform X19

    7. XM_017013518.3XP_016869007.1  regulator of microtubule dynamics protein 1 isoform X5

      Conserved Domains (2) summary
      COG0457
      Location:56289
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:164199
      TPR; TPR repeat [structural motif]
    8. XM_047421828.1XP_047277784.1  regulator of microtubule dynamics protein 1 isoform X4

    9. XM_011517095.3XP_011515397.1  regulator of microtubule dynamics protein 1 isoform X16

      Conserved Domains (1) summary
      sd00006
      Location:178213
      TPR; TPR repeat [structural motif]
    10. XM_011517090.4XP_011515392.1  regulator of microtubule dynamics protein 1 isoform X1

      Conserved Domains (2) summary
      COG0457
      Location:70303
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:178213
      TPR; TPR repeat [structural motif]
    11. XM_005250948.4XP_005251005.1  regulator of microtubule dynamics protein 1 isoform X11

      Conserved Domains (1) summary
      sd00006
      Location:120155
      TPR; TPR repeat [structural motif]
    12. XM_047421831.1XP_047277787.1  regulator of microtubule dynamics protein 1 isoform X10

    13. XM_005250947.4XP_005251004.1  regulator of microtubule dynamics protein 1 isoform X8

      Conserved Domains (2) summary
      COG0457
      Location:82256
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:140169
      TPR; TPR repeat [structural motif]
    14. XM_005250944.4XP_005251001.1  regulator of microtubule dynamics protein 1 isoform X3

      Conserved Domains (2) summary
      COG0457
      Location:56289
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:164199
      TPR; TPR repeat [structural motif]
    15. XM_011517092.3XP_011515394.1  regulator of microtubule dynamics protein 1 isoform X6

      Conserved Domains (2) summary
      COG0457
      Location:96270
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:154183
      TPR; TPR repeat [structural motif]
    16. XM_011517091.3XP_011515393.1  regulator of microtubule dynamics protein 1 isoform X2

      Conserved Domains (2) summary
      sd00006
      Location:174214
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:159216
      TPR_11; TPR repeat
    17. XM_047421840.1XP_047277796.1  regulator of microtubule dynamics protein 1 isoform X30

    18. XM_047421838.1XP_047277794.1  regulator of microtubule dynamics protein 1 isoform X27

    19. XM_047421835.1XP_047277791.1  regulator of microtubule dynamics protein 1 isoform X22

    20. XM_017013521.1XP_016869010.1  regulator of microtubule dynamics protein 1 isoform X20

    21. XM_017013520.1XP_016869009.1  regulator of microtubule dynamics protein 1 isoform X18

    22. XM_011517098.3XP_011515400.1  regulator of microtubule dynamics protein 1 isoform X26

    23. XM_047421836.1XP_047277792.1  regulator of microtubule dynamics protein 1 isoform X23

    24. XM_011517097.3XP_011515399.1  regulator of microtubule dynamics protein 1 isoform X21

      Conserved Domains (1) summary
      sd00006
      Location:154183
      TPR; TPR repeat [structural motif]
    25. XM_017013519.2XP_016869008.1  regulator of microtubule dynamics protein 1 isoform X17

    26. XM_011517096.3XP_011515398.1  regulator of microtubule dynamics protein 1 isoform X15

      Conserved Domains (1) summary
      sd00006
      Location:174214
      TPR; TPR repeat [structural motif]
    27. XM_011517094.3XP_011515396.1  regulator of microtubule dynamics protein 1 isoform X14

      Conserved Domains (1) summary
      sd00006
      Location:178213
      TPR; TPR repeat [structural motif]
    28. XM_011517093.3XP_011515395.1  regulator of microtubule dynamics protein 1 isoform X13

      Conserved Domains (1) summary
      sd00006
      Location:178213
      TPR; TPR repeat [structural motif]
    29. XM_047421842.1XP_047277798.1  regulator of microtubule dynamics protein 1 isoform X32

    30. XM_017013523.2XP_016869012.1  regulator of microtubule dynamics protein 1 isoform X28

    31. XM_047421841.1XP_047277797.1  regulator of microtubule dynamics protein 1 isoform X31

    32. XM_017013522.2XP_016869011.1  regulator of microtubule dynamics protein 1 isoform X25

    RNA

    1. XR_007060734.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      87588507..87634595 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360583.1XP_054216558.1  regulator of microtubule dynamics protein 1 isoform X4

    2. XM_054360595.1XP_054216570.1  regulator of microtubule dynamics protein 1 isoform X16

    3. XM_054360580.1XP_054216555.1  regulator of microtubule dynamics protein 1 isoform X1

    4. XM_054360591.1XP_054216566.1  regulator of microtubule dynamics protein 1 isoform X12

    5. XM_054360608.1XP_054216583.1  regulator of microtubule dynamics protein 1 isoform X29

    6. XM_054360588.1XP_054216563.1  regulator of microtubule dynamics protein 1 isoform X9

    7. XM_054360603.1XP_054216578.1  regulator of microtubule dynamics protein 1 isoform X24

    8. XM_054360586.1XP_054216561.1  regulator of microtubule dynamics protein 1 isoform X7

    9. XM_054360598.1XP_054216573.1  regulator of microtubule dynamics protein 1 isoform X19

    10. XM_054360584.1XP_054216559.1  regulator of microtubule dynamics protein 1 isoform X5

    11. XM_054360590.1XP_054216565.1  regulator of microtubule dynamics protein 1 isoform X11

    12. XM_054360585.1XP_054216560.1  regulator of microtubule dynamics protein 1 isoform X6

    13. XM_054360581.1XP_054216556.1  regulator of microtubule dynamics protein 1 isoform X2

    14. XM_054360579.1XP_054216554.1  regulator of microtubule dynamics protein 1 isoform X33

    15. XM_054360589.1XP_054216564.1  regulator of microtubule dynamics protein 1 isoform X10

    16. XM_054360587.1XP_054216562.1  regulator of microtubule dynamics protein 1 isoform X8

    17. XM_054360582.1XP_054216557.1  regulator of microtubule dynamics protein 1 isoform X3

    18. XM_054360605.1XP_054216580.1  regulator of microtubule dynamics protein 1 isoform X26

    19. XM_054360602.1XP_054216577.1  regulator of microtubule dynamics protein 1 isoform X23

    20. XM_054360600.1XP_054216575.1  regulator of microtubule dynamics protein 1 isoform X21

    21. XM_054360596.1XP_054216571.1  regulator of microtubule dynamics protein 1 isoform X17

    22. XM_054360594.1XP_054216569.1  regulator of microtubule dynamics protein 1 isoform X15

    23. XM_054360593.1XP_054216568.1  regulator of microtubule dynamics protein 1 isoform X14

    24. XM_054360592.1XP_054216567.1  regulator of microtubule dynamics protein 1 isoform X13

    25. XM_054360609.1XP_054216584.1  regulator of microtubule dynamics protein 1 isoform X30

    26. XM_054360606.1XP_054216581.1  regulator of microtubule dynamics protein 1 isoform X27

    27. XM_054360601.1XP_054216576.1  regulator of microtubule dynamics protein 1 isoform X22

    28. XM_054360599.1XP_054216574.1  regulator of microtubule dynamics protein 1 isoform X20

    29. XM_054360597.1XP_054216572.1  regulator of microtubule dynamics protein 1 isoform X18

    30. XM_054360610.1XP_054216585.1  regulator of microtubule dynamics protein 1 isoform X31

    31. XM_054360604.1XP_054216579.1  regulator of microtubule dynamics protein 1 isoform X25

    32. XM_054360611.1XP_054216586.1  regulator of microtubule dynamics protein 1 isoform X32

    33. XM_054360607.1XP_054216582.1  regulator of microtubule dynamics protein 1 isoform X28

    RNA

    1. XR_008487849.1 RNA Sequence