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    TADA2B transcriptional adaptor 2B [ Homo sapiens (human) ]

    Gene ID: 93624, updated on 9-Dec-2024

    Summary

    Official Symbol
    TADA2Bprovided by HGNC
    Official Full Name
    transcriptional adaptor 2Bprovided by HGNC
    Primary source
    HGNC:HGNC:30781
    See related
    Ensembl:ENSG00000173011 MIM:608790; AllianceGenome:HGNC:30781
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ADA2B; ADA2(beta)
    Summary
    TADA2B functions as a transcriptional adaptor protein that potentiates transcription through coordination of histone acetyltransferase (HAT) activity and by linking activation factors to basal transcriptional machinery (Barlev et al., 2003 [PubMed 12972612]).[supplied by OMIM, Apr 2010]
    Expression
    Ubiquitous expression in bone marrow (RPKM 8.1), testis (RPKM 7.9) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See TADA2B in Genome Data Viewer
    Location:
    4p16.1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (7043372..7057952)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (7015207..7029792)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (7045099..7059679)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene TBC1 domain family member 14 Neighboring gene RN7SK pseudogene 292 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr4:7009000-7009638 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr4:7009639-7010278 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21270 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:7017555-7018058 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:7018059-7018562 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:7023455-7024032 Neighboring gene uncharacterized LOC100129931 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15243 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15244 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15245 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21271 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21272 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21273 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:7048917-7049418 Neighboring gene cilia and flagella associated protein 184 Neighboring gene uncharacterized LOC105374368 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:7067016-7067117 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15246 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15247 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15248 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15249 Neighboring gene uncharacterized LOC105374370 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21274 Neighboring gene GrpE like 1, mitochondrial Neighboring gene long intergenic non-protein coding RNA 2447

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC21874

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of DNA repair NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of RNA splicing NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of SAGA complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of SAGA-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of SAGA-type complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    transcriptional adapter 2-beta
    Names
    ADA2-beta
    ADA2-like protein beta
    transcriptional adaptor 2 (ADA2 homolog, yeast)-beta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152293.3NP_689506.2  transcriptional adapter 2-beta

      See identical proteins and their annotated locations for NP_689506.2

      Status: VALIDATED

      Source sequence(s)
      AC097382, AK093974, BC047794
      Consensus CDS
      CCDS47007.1
      UniProtKB/Swiss-Prot
      A0AUJ8, A4QMR7, B3KSN0, B3KU86, Q6MZG9, Q86TJ2
      Related
      ENSP00000308022.6, ENST00000310074.8
      Conserved Domains (1) summary
      COG5114
      Location:6415
      COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      7043372..7057952
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      7015207..7029792
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)