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    LRRC57 leucine rich repeat containing 57 [ Homo sapiens (human) ]

    Gene ID: 255252, updated on 27-Nov-2024

    Summary

    Official Symbol
    LRRC57provided by HGNC
    Official Full Name
    leucine rich repeat containing 57provided by HGNC
    Primary source
    HGNC:HGNC:26719
    See related
    Ensembl:ENSG00000180979 AllianceGenome:HGNC:26719
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Located in extracellular exosome. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 9.0), placenta (RPKM 6.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See LRRC57 in Genome Data Viewer
    Location:
    15q15.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (42528327..42548793, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (40334371..40354843, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (42830027..42840991, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene calpain 3 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:42676684-42677239 Neighboring gene uncharacterized LOC105370794 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr15:42677734-42678933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9299 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9300 Neighboring gene zinc finger protein 106 Neighboring gene RNA, U6 small nuclear 188, pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:42749529-42750361 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:42750362-42751193 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9301 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9302 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9303 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:42787505-42788048 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:42788049-42788592 Neighboring gene synaptosome associated protein 23 Neighboring gene MPRA-validated peak2311 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9304 Neighboring gene HAUS augmin like complex subunit 2 Neighboring gene MYL12B pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    leucine-rich repeat-containing protein 57

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153260.3NP_694992.2  leucine-rich repeat-containing protein 57

      See identical proteins and their annotated locations for NP_694992.2

      Status: VALIDATED

      Source sequence(s)
      AC018362, AK094891, BE301068, BQ130124, CN350663, DA749946
      Consensus CDS
      CCDS10089.1
      UniProtKB/Swiss-Prot
      Q7Z2Z6, Q8N1T6, Q8N9N7
      UniProtKB/TrEMBL
      A0A3B3ISV5
      Related
      ENSP00000380319.3, ENST00000397130.8
      Conserved Domains (2) summary
      PRK15370
      Location:21211
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      sd00033
      Location:4063
      LRR_RI; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      42528327..42548793 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011521423.4XP_011519725.1  leucine-rich repeat-containing protein 57 isoform X1

      UniProtKB/TrEMBL
      A0A3B3ISV5
      Conserved Domains (3) summary
      cd00116
      Location:37191
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:4063
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:3897
      LRR_8; Leucine rich repeat
    2. XM_011521424.4XP_011519726.1  leucine-rich repeat-containing protein 57 isoform X2

      UniProtKB/TrEMBL
      A0A3B3ISV5
      Conserved Domains (3) summary
      cd00116
      Location:37191
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:4063
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:3897
      LRR_8; Leucine rich repeat
    3. XM_047432335.1XP_047288291.1  leucine-rich repeat-containing protein 57 isoform X3

      UniProtKB/Swiss-Prot
      Q7Z2Z6, Q8N1T6, Q8N9N7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      40334371..40354843 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054377652.1XP_054233627.1  leucine-rich repeat-containing protein 57 isoform X1

    2. XM_054377653.1XP_054233628.1  leucine-rich repeat-containing protein 57 isoform X2

    3. XM_054377654.1XP_054233629.1  leucine-rich repeat-containing protein 57 isoform X3

      UniProtKB/Swiss-Prot
      Q7Z2Z6, Q8N1T6, Q8N9N7