Cyp6a8 Cytochrome P450 6a8 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Cyp6a8provided by FlyBase
Official Full Name: Cytochrome P450 6a8provided by FlyBase
Primary source: FLYBASE:FBgn0013772
Locus tag: Dmel_CG10248
See related: AllianceGenome:FB:FBgn0013772
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 6a8; CG10248; cyp6a8; Cyp6A8; CYP6a8; CYP6A8; Cyt-P450-rAF5; Dmel\CG10248; lau; P-450; P450
Summary: Enables alkane 1-monooxygenase activity; fatty acid binding activity; and medium-chain fatty acid omega-1 hydroxylase activity. Involved in insecticide metabolic process; lauric acid metabolic process; and response to caffeine. Located in endomembrane system. Is expressed in adult head; amnioserosa; embryonic/larval Malpighian tubule; and yolk nucleus. Human ortholog(s) of this gene implicated in Ghosal hematodiaphyseal syndrome; cerebral infarction; essential hypertension; familial Mediterranean fever; and leukemia (multiple). Orthologous to several human genes including CYP3A7-CYP3A51P (CYP3A7-CYP3A51P readthrough); CYP3A4 (cytochrome P450 family 3 subfamily A member 4); and CYP3A43 (cytochrome P450 family 3 subfamily A member 43). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 51D1-51D1; 2-73 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (14887171..14889010, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (10774676..10776515, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Caffeine, DDT and phenobarbital have synergistic effects on the transcriptional activity of Cyp6a8 upstream DNAs.
Title: Functional analysis of the cis-acting elements responsible for the induction of the Cyp6a8 and Cyp6g1 genes of Drosophila melanogaster by DDT, phenobarbital and caffeine.
Organization of Cyp6a8 and promoter activity of its upstream DNA were analyzed.
Title: Cyp6a8 of Drosophila melanogaster: gene structure, and sequence and functional analysis of the upstream DNA.
This is the first report showing that a member of the CYP6 family catalyzes the hydroxylation of lauric acid.
Title: Drosophila melanogaster CYP6A8, an insect P450 that catalyzes lauric acid (omega-1)-hydroxylation.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables alkane 1-monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables fatty acid binding	IDA Inferred from Direct Assay more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables medium-chain fatty acid omega-1 hydroxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in insecticide metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in lauric acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in response to caffeine	IDA Inferred from Direct Assay more info	PubMed