PMC1 calcium-transporting ATPase PMC1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: PMC1
Official Full Name: calcium-transporting ATPase PMC1
Primary source: SGD:S000002974
Locus tag: YGL006W
See related: AllianceGenome:SGD:S000002974; FungiDB:YGL006W; VEuPathDB:YGL006W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables P-type calcium transporter activity. Involved in calcium ion transport; intracellular calcium ion homeostasis; and transmembrane transport. Located in fungal-type vacuole membrane. Used to study Hailey-Hailey disease. Human ortholog(s) of this gene implicated in X-linked spinocerebellar ataxia 1; autosomal dominant intellectual developmental disorder; autosomal dominant nonsyndromic deafness; and autosomal recessive nonsyndromic deafness 12. Orthologous to several human genes including ATP2B2 (ATPase plasma membrane Ca2+ transporting 2) and ATP2B3 (ATPase plasma membrane Ca2+ transporting 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See PMC1 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (485921..489442)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phosphatidylinositol 3,5-bisphosphate regulates Ca(2+) transport during yeast vacuolar fusion through the Ca(2+) ATPase Pmc1.
Title: Phosphatidylinositol 3,5-bisphosphate regulates Ca(2+) transport during yeast vacuolar fusion through the Ca(2+) ATPase Pmc1.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled monoatomic cation transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables P-type calcium transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables P-type calcium transporter activity	IEA Inferred from Electronic Annotation more info
enables P-type calcium transporter activity	IGI Inferred from Genetic Interaction more info	PubMed
enables P-type calcium transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables P-type ion transporter activity	IEA Inferred from Electronic Annotation more info
enables inorganic cation transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inorganic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in fungal-type vacuole membrane	HDA more info	PubMed
located_in fungal-type vacuole membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info
located_in vacuole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: calcium-transporting ATPase PMC1

NP_011509.1

EC 7.2.2.10

Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in presence of elevated concentrations of calcium; targeted to vacuole via AP-3 pathway; similar to mammalian PMCA1a

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

485921..489442

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180871.1 → NP_011509.1 TPA: calcium-transporting ATPase PMC1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011509.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VUD2, P38929

UniProtKB/TrEMBL

A6ZUY7, B3LIM1, N1P5M0

Conserved Domains (1) summary

TIGR01517
Location:15 → 1123

ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase