lt light [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ltprovided by FlyBase
Official Full Name: lightprovided by FlyBase
Primary source: FLYBASE:FBgn0002566
Locus tag: Dmel_CG18028
See related: AllianceGenome:FB:FBgn0002566
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG18028; Dm-lt(het); Dmel\CG18028; l(2)40Fb; Lt; vps41; Vps41
Summary: Predicted to enable zinc ion binding activity. Involved in several processes, including autophagosome maturation; determination of adult lifespan; and endosomal vesicle fusion. Part of HOPS complex. Is expressed in several structures, including adult head; embryonic/larval fat body; embryonic/larval salivary gland; gonad; and larval brain. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 29. Orthologous to human VPS41 (VPS41 subunit of HOPS complex). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 40F7-40F7; 2-54 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (22924795..22943135)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (22817527..22835867)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables zinc ion binding	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in Notch receptor processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagosome maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in crinophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosomal vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosomal vesicle fusion	IEA Inferred from Electronic Annotation more info
involved_in endosomal vesicle fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular transport	TAS Traceable Author Statement more info	PubMed
involved_in lysosomal transport	TAS Traceable Author Statement more info	PubMed
involved_in macroautophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein targeting to vacuole	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein targeting to vacuole	IEA Inferred from Electronic Annotation more info
involved_in regulation of SNARE complex assembly	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in symbiont entry into host cell	HMP more info	PubMed
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
part_of HOPS complex	IBA Inferred from Biological aspect of Ancestor more info
part_of HOPS complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of HOPS complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in late endosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: light

Names: CG18028-PA; CG18028-PC; CG18028-PE; CG18028-PF; lt-PA; lt-PC; lt-PE; lt-PF; pink-wing; pinkoid

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

22924795..22943135

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001042950.3 → NP_001036415.2 light, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036415.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O76248, Q7PL76, Q7PL77, Q8MT46

Conserved Domains (4) summary

smart00299
Location:570 → 707

CLH; Clathrin heavy chain repeat homology

pfam00637
Location:580 → 708

Clathrin; Region in Clathrin and VPS

sd00039
Location:33 → 81

7WD40; WD40 repeat [structural motif]

cl02567
Location:42 → 204

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001273766.1 → NP_001260695.1 light, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260695.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O76248, Q7PL76, Q7PL77, Q8MT46

Conserved Domains (4) summary

smart00299
Location:570 → 707

CLH; Clathrin heavy chain repeat homology

pfam00637
Location:580 → 708

Clathrin; Region in Clathrin and VPS

sd00039
Location:33 → 81

7WD40; WD40 repeat [structural motif]

cl02567
Location:42 → 204

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001042951.2 → NP_001036416.1 light, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036416.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O76248, Q7PL76, Q7PL77, Q8MT46

Conserved Domains (4) summary

smart00299
Location:570 → 707

CLH; Clathrin heavy chain repeat homology

pfam00637
Location:580 → 708

Clathrin; Region in Clathrin and VPS

sd00039
Location:33 → 81

7WD40; WD40 repeat [structural motif]

cl02567
Location:42 → 204

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001042952.2 → NP_001036417.1 light, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036417.1

Status: REVIEWED

Conserved Domains (3) summary

smart00299
Location:257 → 394

CLH; Clathrin heavy chain repeat homology

smart00184
Location:477 → 519

RING; Ring finger

pfam00637
Location:267 → 395

Clathrin; Region in Clathrin and VPS