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    CSN1a COP9 signalosome subunit 1a [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34857, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CSN1aprovided by FlyBase
    Official Full Name
    COP9 signalosome subunit 1aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028838
    Locus tag
    Dmel_CG4697
    See related
    AllianceGenome:FB:FBgn0028838
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG:DS06874.2; CG4697; CH1-1; Cop9; COP9; csn1; CSN1; csn1a; Csn1a; Csn1A; Dch1; Dch1-1; Dmel\CG4697
    Summary
    Predicted to be involved in protein deneddylation. Predicted to be part of COP9 signalosome. Orthologous to human GPS1 (G protein pathway suppressor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CSN1a in Genome Data Viewer
    Location:
    35B5-35B5; 2-50 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (14762765..14764065)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (14762765..14764065)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44858 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The COP9 signalosome is essential for development of Drosophila melanogaster. Freilich S, et al. Curr Biol, 1999 Oct 21. PMID 10531038
    2. CSN-mediated deneddylation differentially modulates Ci(155) proteolysis to promote Hedgehog signalling responses. Wu JT, et al. Nat Commun, 2011 Feb 8. PMID 21304511, Free PMC Article
    3. Protein competition switches the function of COP9 from self-renewal to differentiation. Pan L, et al. Nature, 2014 Oct 9. PMID 25119050
    4. The COP9 signalosome. Wei N, et al. Annu Rev Cell Dev Biol, 2003. PMID 14570571
    5. Drosophila COP9 signalosome subunit 7 interacts with multiple genomic loci to regulate development. Singer R, et al. Nucleic Acids Res, 2014 Sep. PMID 25106867, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in protein deneddylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of COP9 signalosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COP9 signalosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    COP9 signalosome subunit 1a
    Names
    CG4697-PA
    COP9 complex homolog subunit 1 a
    CSN1a-PA
    drosophila COP9 signalosome homolog 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      14762765..14764065
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135876.2 → NP_609720.1  COP9 signalosome subunit 1a [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609720.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJR9
      Related
      FBpp0080233
      Conserved Domains (1) summary
      pfam10602
      Location:105 → 281
      RPN7; 26S proteasome subunit RPN7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJR9 Q9VJR9

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