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    Tg Transglutaminase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34093, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Tgprovided by FlyBase
    Official Full Name
    Transglutaminaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031975
    Locus tag
    Dmel_CG7356
    See related
    AllianceGenome:FB:FBgn0031975
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7356; Dmel\CG7356; DmTG; dTG; dTG-alpha; tg; TG
    Summary
    Enables protein-glutamine gamma-glutamyltransferase activity. Involved in hemolymph coagulation. Located in extracellular space and vesicle. Is expressed in several structures, including adult head; adult heart; dorsal pharyngeal muscle cell; dorsal vessel wall cell; and larval imaginal tissue. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autosomal recessive congenital ichthyosis 1; factor XIII deficiency; peeling skin syndrome 2; and thrombophilia (multiple). Orthologous to several human genes including TGM1 (transglutaminase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    28D3-28D3; 2-29 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8011405..8026898)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8011405..8026898)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Glycine N-acyltransferase Neighboring gene uncharacterized protein Neighboring gene barrier to autointegration factor Neighboring gene Connector of kinase to AP-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila TG-A transglutaminase is secreted via an unconventional Golgi-independent mechanism involving exosomes and two types of fatty acylations. Shibata T, et al. J Biol Chem, 2017 Jun 23. PMID 28476891, Free PMC Article
    2. Inhibition of transglutaminase exacerbates polyglutamine-induced neurotoxicity by increasing the aggregation of mutant ataxin-3 in an SCA3 Drosophila model. Lin Y, et al. Neurotox Res, 2015 Apr. PMID 25501875
    3. Targeted overexpression of Drosophila transglutaminase-B induced characteristic phenotypes in a manner similar to transglutaminase-a. Ichikawa A, et al. Biosci Biotechnol Biochem, 2011. PMID 21737915
    4. Transglutaminase-catalyzed protein-protein cross-linking suppresses the activity of the NF-κB-like transcription factor relish. Shibata T, et al. Sci Signal, 2013 Jul 23. PMID 23882120
    5. Crosslinking of a Peritrophic Matrix Protein Protects Gut Epithelia from Bacterial Exotoxins. Shibata T, et al. PLoS Pathog, 2015 Oct. PMID 26506243, Free PMC Article

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TG-A is secreted through an unconventional ER/Golgi-independent pathway involving two types of fatty acylations and exosomes.
      Title: Drosophila TG-A transglutaminase is secreted via an unconventional Golgi-independent mechanism involving exosomes and two types of fatty acylations.
    2. These findings suggest that intracellular TG regulates Relish-N-mediated transcriptional activity by incorporating polyamines into Relish-N and via protein-protein cross-linking.
      Title: Transglutaminase-catalyzed incorporation of polyamines masks the DNA-binding region of the transcription factor Relish.
    3. Targeted overexpression of Drosophila transglutaminase-B induced characteristic phenotypes in a manner similar to transglutaminase-a
      Title: Targeted overexpression of Drosophila transglutaminase-B induced characteristic phenotypes in a manner similar to transglutaminase-a.
    4. Over-expression of transglutaminase in the Drosophila eye imaginal disc induces a rough eye phenotype.
      Title: Over-expression of transglutaminase in the Drosophila eye imaginal disc induces a rough eye phenotype.
    5. we identify the Transglutaminase gene (Tg; CG7356) as a direct transcriptional target of MEF2 in the cardiac musculature
      Title: Cardiac expression of the Drosophila Transglutaminase (CG7356) gene is directly controlled by myocyte enhancer factor-2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 8013669-8018814 mobile_element_type = transposon:copia{}324
    • Loc: 8018860-8023579 mobile_element_type = transposon:Doc{}325

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein-glutamine gamma-glutamyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-glutamine gamma-glutamyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-glutamine gamma-glutamyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in hemolymph coagulation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in hemolymph coagulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptide cross-linking IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transglutaminase
    Names
    CG7356-PA
    CG7356-PB
    Tg-PA
    Tg-PB
    Transglutaminase-A
    NP_609174.1
    NP_723332.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8011405..8026898
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135330.2 → NP_609174.1  transglutaminase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609174.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0IQ93, Q9VLU2
      Related
      FBpp0079155
      Conserved Domains (3) summary
      smart00460
      Location:324 → 419
      TGc; Transglutaminase/protease-like homologues
      pfam00868
      Location:56 → 179
      Transglut_N; Transglutaminase family
      pfam00927
      Location:538 → 644
      Transglut_C; Transglutaminase family, C-terminal ig like domain

    2. NM_164778.2 → NP_723332.1  transglutaminase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723332.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0IQ93, Q8IPH0
      Related
      FBpp0079156
      Conserved Domains (3) summary
      smart00460
      Location:316 → 411
      TGc; Transglutaminase/protease-like homologues
      pfam00868
      Location:48 → 171
      Transglut_N; Transglutaminase family
      pfam00927
      Location:530 → 636
      Transglut_C; Transglutaminase family, C-terminal ig like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IPH0 Q8IPH0
    Q9VLU2 Q9VLU2

    Gene LinkOut

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